Probing tissue replacement strategies as a therapeutic intervention to facilitate restoration of the peri-infarct region after stroke (A04)

• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 548585053

This project investigates brain tissue replacement therapy using human stem-cell-derived cortical organoids implanted into the infarct core after stroke. By combining human cortical organoid transplantation with advanced two-photon calcium imaging in behaving mice, the project assesses how grafted tissue integrates into vascular and neural networks of the peri-infarct area. It further explores the role of graft composition and aging on recovery outcomes, aiming to develop a foundation for personalized regenerative strategies for chronic stroke patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1744: Compartmentalized cellular networks in neurovascular diseases
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Simon T. Schäfer; Professorin Anna-Sophia Wahl, Ph.D.