Project Details
Projekt
Dysregulation of Iron homeostasis-induced cellular inflammatory and neuro-degenerative processes in glaucoma (C08#)
Subject Area
Ophthalmology
Term
since 2026
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 501530074
This project will characterize the underlying mechanism between IOP, impaired iron homeostasis, microglial activation, and neuroinflammatory signaling related to a vicious circle of retinal ganglion cell loss. The investigation of IOP elevation and cellular neuroinflammation will be performed in vitro in retinal tissue as well as in in vivo models (i.e. episcleral vein cauterization). Analysis of aqueous humor, retina, and serum from glaucoma patients will follow. Murine models of hepcidin deficiency and hepcidin increase will be exposed to the IOP models, thereby revealing signaling mechanisms and offering therapeutical opportunities.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 1607:
Towards immunomodulatory and anti(lymph)angiogenic therapies for age-related blinding eye diseases
Applicant Institution
Universität zu Köln
