Structural basis of mechanosensing by protein kinases (A04)

• Subject Area: Structural Biology ; Biophysics
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 550938463

This project aims to elucidate the structural and molecular basis of kinase-mediated mechanosensing by using a combination of high-pressure nuclear magnetic resonance (NMR) spectroscopy, X-ray crystallography, spring polymer engineering, and biochemical assays to study mechanosensory kinases of the titin family. The findings will reveal how mechanical force modulates kinase activity and will thus enhance the understanding of chemical and biological responses in mechanosensing.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1756: Chemical and Biological Principles of Cellular Trigger Responses
• Applicant Institution: Universität Konstanz
• Project Heads: Professor Dr. Michael Kovermann; Professorin Dr. Olga Mayans