Boron-Nitrogen Heterocycles as Fluorescent Labels for Nucleic Acids (C01)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 551403841

Project C01 “Boron-Nitrogen Heterocycles as Fluorescent Labels for Nucleic Acids” aims to explore BN-PAHs as a new class of building blocks for chemically modified nucleosides that are of interest as fluorescent probes of nucleic acid structure and function. The goal is to develop syntheses of novel BN-PAH-derived nucleosides and oligonucleotides and the exploration of their structural, photophysical, and fluorescence properties. Responsive fluorescent probes e.g. for DNA structural changes, DNA/RNA hybridization events, protein binding, potentially in real-time are in the focus.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1762: Boron as property-determining element
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Holger Helten; Professorin Dr. Claudia Höbartner