Synthesis and Evaluation of Functionalized Boron Clusters for Bioconjugation and Cellular Delivery (C02)

• Subject Area: Biological and Biomimetic Chemistry
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 551403841

Project C02 “Synthesis and Evaluation of Functionalized Boron Clusters for Bioconjugation and Cellular Delivery” aims at the synthesis of boron-cluster-modified biomolecules with enhanced bioavailability and bioactivity. Synthetic strategies for anionic per- and polyhalogenated superchaotropic boron clusters with functional substituents for covalent binding to biomolecular structures will be developed. Principles that modulate the ability to transport various types of cargo through lipid bilayers will be investigated paving the path e.g. to a future development of nucleoside prodrugs and therapeutic oligonucleotides for gene expression regulation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1762: Boron as property-determining element
• Applicant Institution: Julius-Maximilians-Universität Würzburg
• Project Heads: Professor Dr. Maik Finze; Professorin Dr. Claudia Höbartner