Upgrade of a 600 MHz NMR spectrometer with a new console, 19F QCI(P)-cryoprobe and sample changer

• Subject Area: Basic Research in Biology and Medicine
• Term: Funded in 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 576387757

The hardware of the 600 MHz NMR spectrometer at the North Bavarian NMR Center (NBNC) at the University of Bayreuth (UBT) is no longer state-of-the-art. The current console, in use for over 19 years, is no longer supported and is incompatible with the latest NMR operating software. In recent years, the instrument had down times due to repairs significantly limiting the availability for measurements. To remain fully functional and internationally competitive in the coming decades, an upgrade to the latest console generation is essential. In addition, we request a new cryoprobe to significantly enhance sensitivity and experimental variability. The proposed cryoprobe will include a ¹⁹F and 31P channel, enabling the detection of interactions and conformational dynamics of large biomolecular complexes (including protein–RNA as-assemblies) and RNAs at low concentrations. It will also support high-throughput screening of ¹⁹F-labelled small-molecule inhibitors against a broad range of enzymes and protein–RNA targets. The use of ¹⁹F NMR has proven to be highly valuable across a variety of research fields, particularly in biomolecular NMR. Moreover, it will substantially expand the experimental capabilities of the NBNC and broaden the application of NMR spectroscopy in fields including, but not limited to, sustainable chemistry, energy research, environmental research and health profiling. To further improve efficiency, especially for high-throughput applications, we also request the replacement of the existing 120-position autosampler, which is technically incompatible with modern consoles due to changes in the bus system, by a modern sample chang-er. This is mandatory for the continuation of ongoing and planned profiling studies of body fluids (urine, blood, tissue extracts) and foods for chemometric modelling. The NBNC at UBT is distinguished by its broad application of NMR spectroscopy, spanning biological research as well as materials science, organic, inorganic, physical, and food chemistry. Therefore, upgrading the 600 MHz spectrometer, including the console, cryoprobe, and sample changer, is crucial for supporting the regional research community, strengthening international collaborations, and maintaining a leading position in global NMR research.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Erweiterung eines 600 MHz NMR-Geräts mit einer neuen Konsole, 19F-Kryoprobenkopf und Probenwechsler
• Instrumentation Group: 1740 Hochauflösende NMR-Spektrometer
• Applicant Institution: Universität Bayreuth
• Leader: Professor Dr. Janosch Hennig