A single-cell molecular blueprint of thalamocortical circuit assembly

• Applicant: Dr. Philipp Abe
• Subject Area: Developmental Neurobiology
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 577066387

The thalamus is a complex brain structure that forms extensive reciprocal connections with the cerebral cortex via thalamocortical (TC) circuits. Proper functionality of this network is crucial for diverse higher-order cognitive functions and plays key roles in brain development. However, the precise mechanisms governing the specification and targeting of TC circuits remain largely unknown. This project aims to unravel the complexity of TC circuit assembly during thalamic development by leveraging a novel pipeline that integrates single-cell RNA sequencing with retrograde tracing. This approach will identify developmental programs and link them to TC connectivity dynamics, ultimately generating a molecular-to-anatomical blueprint of thalamic projection neurons. This resource will provide fundamental insights into the principles of brain development and open new possibilities, ranging from advancing our understanding of nervous system evolution to developing treatments for human cognitive disorders. The applicant intends to use this research as a foundation to establish an independent research group.

• DFG Programme: Research Grants