Photoactivatable ruthenium(II) complexes as targeting PACT and PCET agents: a systematic, combinatorial, automated and high-throughput approach and their conjugation to nanobodies

• Applicant: Dr. Tabea Lenz
• Subject Area: Inorganic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2026
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 581205373

This project aims to design a platform for a semi-automated, high-throughput synthetic (HTS) approach of libraries of light-responsive ruthenium(II) complexes to systematically identify the suitability for photodynamic therapy (PDT), photoactivated chemotherapy (PACT) or proton-coupled electron transfer (PCET). Focusing on application in PACT and PCET, key compounds will be conjugated to nanobodies, enhancing specific cellular targeting for the use as anticancer agents.

• DFG Programme: Fellowship
• International Connection: United Kingdom
• Host: Professor Dr. Ramon Vilar Compte