Modeling of the transfer of adoptive immunity to hepatitis B and C virus in liver transplantation

• Applicant: Dr. Melanie Fiedler
• Subject Area: General and Visceral Surgery
• Term: from 2008 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5397027

• Final Report Year: 2012

Final Report Abstract

We successfully generated an HCV-prototype vaccine based on HBV capsid-like particles presenting mimotopes of the HCV E2-envelope protein. These HCV-CLPs were highly immunogenic in mice and the induced antibodies had great potential in cross-neutralizing different HCV strains including patient isolates. This prototype vaccine now permits the analysis of adoptive immune transfer in HCV-related liver transplantation.

Publications

• Adoptive immune transfer of hepatitis B virus specific immunity from immunized living liver donors to liver recipients. Transplantation 2009, 87: 103-111
  Schumann, Alexandra; Lindemann, Monika; Valentin-Gamazo, Camino; Lu, Mengji; Elmaagacli, Ahmet; Dahmen, Uta; Knop, Dietmar; Broelsch, Christoph E.; Grosse-Wilde, Hans; Roggendorf, Michael & Fiedler, Melanie