Vitamin B6 dependence of one-carbon metabolism quantified in human subjects

Applicant Dr. Katja Yvonne Lamers

Subject Area Nutritional Sciences

Term from 2007 to 2009

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 61580964

Final Report Year 2009

Final Report Abstract

No abstract available

Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-13C2]glycine and [2H3]leucine. J Nutr 2007;137:2647-52
Lamers Y, Williamsorn J, Gilbert LR, Stacpoole PW, Gregory JF
Generation of CO2 from glycine carbons indicates high production of 1-carbon units from glycine in healthy men and women. J Nutr
Lamers Y, Williamson J, Theriaque DW, Shuster JJ, Gilbert LR, Keeling C, Stacpoole PW, Gregory JF
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. J Nutr
Lamers Y, Williamson J, Ralat M, Quinlivan EP, Gilbert LR, Keeling C, Stevens RD, Newgard CB, Ueland PM, Meyer K, Fredriksen A, Stacpoole PW, Gregory JF
Vitamin B-6 restriction tends to reduce red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women. American Journal of Clinical Nutrition
Lamers Y, O'Rourke B, Gilbert LR, Keeling C, Matthews DE, Stacpoole PW, Gregory JF