Common resources of the research unit

• Applicant: Professor Dr. Andreas Zimmer
• Subject Area: Biological Psychiatry
• Term: from 2008 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 42860621

• Final Report Year: 2017

Final Report Abstract

The main task of CP2 was the establishment of animal colonies providing genetic mouse models for all investigators in the Research Unit. CP 2 also provided administrative support and facilitated scientific exchange within the Research Unit by organizing regular meetings and workshops.

Publications

• (2013). Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol, 66:126-132
  Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G
  (See online at https://doi.org/10.1016/j.yjmcc.2013.11.013)
• (2013). Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory. Front Aging Neurosci. Epub 2012 Dec 5
  Albayram O, Bilkei-Gorzo A, Zimmer A
  (See online at https://doi.org/10.3389/fnagi.2012.00034)
• (2014). Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol Aging, 36:710-719
  Schmöle AC, Lundt R, Ternes S, Albayram O, Ulas T, Schultze JL, Bano D, Nicotera P, Alferink J, Zimmer A
  (See online at https://doi.org/10.1016/j.neurobiolaging.2014.09.019)
• (2014). CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes. Life Sci, 138 (2015) 18-28
  Heinemann JC, Duerr GD, Keppel K, Breitbach M, Fleischmann BK, Zimmer A, Wehner S, Welz A, Dewald O
  (See online at https://doi.org/10.1016/j.lfs.2014.11.027)
• (2014). The CB1 Receptor as an Important Mediator of Hedonic Reward Processing. Neuropsychopharmacology, 39(10):2387-96
  Friemel CM, Zimmer A, Schneider M
  (See online at https://doi.org/10.1038/npp.2014.86)
• (2014). The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol, 109(4):425
  Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O
  (See online at https://doi.org/10.1007/s00395-014-0425-x)
• (2015). Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int, 2015:456582
  Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O
  (See online at https://doi.org/10.1155/2015/456582)
• (2015). Enhanced microglial activity in FAAH-/- animals. Life Sci, 138:52-56
  Ativie F, Albayram O, Bach K, Pradier B, Zimmer A, Bilkei-Gorzo A
  (See online at https://doi.org/10.1016/j.lfs.2014.12.016)
• (2015). Inhibition of FAAH reduces nitroglycerin-induced migraine-like pain and trigeminal neuronal hyperactivity in mice. Eur Neuropsychopharmacol, 25(8):1388-96
  Nozaki C, Markert A, Zimmer A
  (See online at https://doi.org/10.1016/j.euroneuro.2015.04.001)
• (2016). Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. Naunyn Schmiedebergs Arch Pharmacol. 389(6):603-12
  Feliszek M, Bindila L, Lutz B, Zimmer A, Bilkei-Gorzo A, Schlicker E
  (See online at https://doi.org/10.1007/s00210-016-1226-6)