Syntheses of biofunctional scaffold architectures for multivalent interactions (A06)

• Subject Area: Preparatory and Physical Chemistry of Polymers ; Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32049920

The project contributes to the investigation of facial interactions on multivalent scaffolds for a deeper understanding of multivalency in biological systems. This will result in a knowledge transfer to biophysical and theoretical projects within the collaborative research centre. In the third funding period especially multivalent surface interactions of 2D polymer structures as well as switchable supramolecular scaffolds will be examined more closely. On the one hand, the functionalization of flexible nanogels will be extended to different biologically active ligands. On the other hand the synthesis of 2D polymers based on functionalized graphene derivatives is planned to further increase the multivalent inhibition of pathogen surfaces.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
• Applicant Institution: Freie Universität Berlin
• Project Head: Professor Dr. Rainer Haag