Interaction of adjustable ligand-conjugates with biological systems (B07)

• Subject Area: Biochemistry ; Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32049920

Electrostatic interactions play an important role in protein recognition at the molecular level. Linear and globular anionic polymers, as well as precisely fitting compounds with complementary charge of the receptor surfaces will be analyzed. Targets are the oligovalent proteins LOX-1 and C1q. In vitro binding studies including cellular readout systems will be applied to promote an iterative process of chemical synthesis. Aim of the project is to realize maximal shielding of target proteins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
• Applicant Institution: Freie Universität Berlin
• Co-Applicant Institution: Charité - Universitätsmedizin Berlin
• Project Heads: Privatdozent Dr. Jens Dernedde; Professor Dr. Rudolf Tauber, until 12/2015