No-equilibrium kinetics of multivalent binding processes (C02)

• Subject Area: Theoretical Chemistry: Electronic Structure, Dynamics, Simulation ; Mathematics
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 32049920

For the correct modeling of the binding kinetics of multivalent systems, it has to be taken into account that single binding events can take place within the fast time-scales of local conformational changes. The binding kinetics inherits a spatial component. This has to be modeled correctly with a novel mathematical framework. The modeling of non-equlibrium kinetics will play an important role in the third funding period and should also be included in this framework. Recently, it turned out that isothermal titration calorimetry (ITC) can be used for the investigation of binding kinetics, too. This will be exploited in our project.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 765: Multivalency as Chemical Organisation and Action Principle: New Architectures, Functions and Applications
• Applicant Institution: Freie Universität Berlin
• Co-Applicant Institution: Zuse-Institut Berlin (ZIB)
• Project Head: Privatdozent Dr. Marcus Weber