Functional control of dopamine release in humans: changes in aging and the modifying role of the locus coeruleus (LC) (A07)

• Subject Area: Human Cognitive and Systems Neuroscience
• Term: from 2008 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36555331

The goal of project A07 is to delineate the functional network level regulation of dopamine release in response to novelty and action for reward and to investigate the relationship between dopamine release and memory consolidation in young and old adults. To achieve these goals, we will continue our successfully established multimodal approach of combining imaging at 3T, 7T and PET. We will achieve a direct integration of fMRI and dopamine release by using a new, truly simultaneous MR-PET facility in Magdeburg. We will also determine whether a norardrenergic brain region, the locus coeruleus, may be a bottleneck for dopamine-release in the hippocampus.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 779: Neurobiology of Motivated Behaviour
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Emrah Düzel; Professor Dr. Oliver Speck