FOR 1086:  K2P-Kanäle - vom Molekül zur Physiologie und Pathophysiologie

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2008 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 66618578

• Erstellungsjahr: 2015

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

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• Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. Journal of Biological Chemistry, Vol. 284. 2009, pp. 2106-2113.
  Halaszovich, Christian R.; Schreiber, Daniela N. & Oliver, Dominik
  
• Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. Journal of Physiology, Vol. 587. 2009, Issue 5, pp. 929-952.
  Zuzarte, Marylou; Heusser, Katja; Renigunta, Vijay; Schlichthörl, Günter; Rinné, Susanne; Wischmeyer, Erhard; Daut, Jürgen; Schwappach, Blanche & Preisig‐Müller, Regina
  
• Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice. Pflügers Archiv - European Journal of Physiology, Vol. 459. 2010, pp. 969–976.
  Köhler, Ralf & Ruth, Peter
  
• Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cellular Physiology and Biochemistry, Vol.28. 2011, No. 1, pp. 77–86.
  Decher, Niels; Wemhöner, Konstantin; Rinné, Susanne; Netter, Michael F.; Zuzarte, Marylou; Aller, Maria I.; Kaufmann, Susann G.; Li, Xian Tao; Meuth, Sven G.; Daut, Jürgen; Sachse, Frank B. & Maier, Sebastian K.G.
  
• The pore structure and gating mechanism of K2P channels. EMBO Journal Vol. 30. 2011, Issue 21, pp. 3607-3619.
  Piechotta, Paula L; Rapedius, Markus; Stansfeld, Phillip J; Bollepalli, Murali K; Ehrlich, Gunter; Andres-Enguix, Isabelle; Fritzenschaft, Hariolf; Decher, Niels; Sansom, Mark S P; Tucker, Stephen J & Baukrowitz, Thomas
  
• Dkk3 is a component of the genetic circuitry regulating aldosterone synthesis in the adrenal cortex. Human Molecular Genetics, Vol. 21. 2012, Issue 22, 15 pp. 4922–4929.
  El Wakil, Abeer; Bandulik, Sascha; Guy, Nicolas; Bendahhou, Saïd; Zennaro, Maria-Christina; Niehrs, Christof; Mari, Bernard; Warth, Richard; Barhanin, Jacques & Lalli, Enzo
  
• Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmachertherapie & Elektrophysiologie, Vol. 23. 2012, pp. 211–219.
  Zumhagen, Sven; Stallmeyer, Birgit; Friedrich, Corinna; Eckardt, Lars; Seebohm, Guiscard & Schulze-Bahr, Eric
  
• State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels, Vol. 6. 2012, Issue 6, pp. 473-478.
  Rapedius, Markus; Schmidt, Matthias R.; Sharma, Chetan; Stansfeld, Phillip J.; Sansom, Mark S.P.; Baukrowitz, Thomas & Tucker, Stephen J.
  
• The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. Cardiovascular Research, Vol. 97. 2013, Issue 1, pp. 97–105.
  Schiekel, Julia; Lindner, Moritz; Hetzel, Andrea; Wemhöner, Konstantin; Renigunta, Vijay; Schlichthörl, Günter; Decher, Niels; Oliver, Dominik & Daut, Jürgen
  
• Alterations of N-3 Polyunsaturated Fatty Acid-Activated K2P Channels in Hypoxia-Induced Pulmonary Hypertension. Basic & clinical pharmacology & toxicology, Vol. 113. 2013, Issue 4, pp. 250-258.
  Nielsen, Gorm; Wandall‐Frostholm, Christine; Sadda, Veeranjaneyulu; Oliván‐Viguera, Aida; Lloyd, Eric E.; Bryan, Robert M.; Simonsen, Ulf & Köhler, Ralf
  
• Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflügers Archiv - European Journal of Physiology, Vol. 466. 2014, pp. 1735–1745.
  Renigunta, Vijay; Zou, Xinle; Kling, Stefan; Schlichthörl, Günter & Daut, Jürgen
  
• Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology, Vol. 154. 2013, Issue 8, pp. 2712–2722.
  Bandulik, Sascha; Tauber, Philipp; Penton, David; Schweda, Frank; Tegtmeier, Ines; Sterner, Christina; Lalli, Enzo; Lesage, Florian; Hartmann, Michaela; Barhanin, Jacques & Warth, Richard
  
• Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nature Communications, Vol. 5. 2014, Article number: 5540.
  Wilke, Bettina U.; Lindner, Moritz; Greifenberg, Lea; Albus, Alexandra; Kronimus, Yannick; Bünemann, Moritz; Leitner, Michael G. & Oliver, Dominik
  
• Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. Journal of Physiology, Vol. 593. 2015, Issue 1, pp. 127-144.
  Bista, Pawan; Pawlowski, Matthias; Cerina, Manuela; Ehling, Petra; Leist, Michael; Meuth, Patrick; Aissaoui, Ania; Borsotto, Marc; Heurteaux, Catherine; Decher, Niels; Pape, Hans‐Christian; Oliver, Dominik; Meuth, Sven G. & Budde, Thomas
  
• Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1081–1090.
  Kiper, Aytug K.; Rinné, Susanne; Rolfes, Caroline; Ramírez, David; Seebohm, Guiscard; Netter, Michael F.; González, Wendy & Decher, Niels
  
• The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, Issue 5. pp. 895–905.
  Bista, Pawan; Cerina, Manuela; Ehling, Petra; Leist, Michael; Pape, Hans-Christian; Meuth, Sven G. & Budde, Thomas
  
• TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. Journal of Molecular and Cellular Cardiology, Vol. 81. 2015, pp. 71-80.
  Rinné, Susanne; Kiper, Aytug K.; Schlichthörl, Günter; Dittmann, Sven; Netter, Michael F.; Limberg, Sven H.; Silbernagel, Nicole; Zuzarte, Marylou; Moosdorf, Rainer; Wulf, Hinnerk; Schulze-Bahr, Eric; Rolfes, Caroline & Decher, Niels
  
• The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1105–1120.
  Kilisch, Markus; Lytovchenko, Olga; Schwappach, Blanche; Renigunta, Vijay & Daut, Jürgen