FOR 1086:  K2P-Kanäle - vom Molekül zur Physiologie und Pathophysiologie

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2008 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 66618578

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

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• Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. Journal of Biological Chemistry, Vol. 284. 2009, pp. 2106-2113.
  Halaszovich C.R., Schreiber D.N., Oliver D.
  (Siehe online unter https://dx.doi.org/10.1074/jbc.M803543200)
• Intracellular traffic of the K+ channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. Journal of Physiology, Vol. 587. 2009, Issue 5, pp. 929-952.
  Zuzarte M., Heusser K., Renigunta V., Schlichthörl G., Rinné S., Wischmeyer E., Daut J., Schwappach B., Preisig-Müller R.
  (Siehe online unter https://doi.org/10.1113/jphysiol.2008.164756)
• Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice. Pflügers Archiv - European Journal of Physiology, Vol. 459. 2010, pp. 969–976.
  Köhler R., Ruth P.
  (Siehe online unter https://doi.org/10.1007/s00424-010-0819-z)
• Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cellular Physiology and Biochemistry, Vol.28. 2011, No. 1, pp. 77–86.
  Decher N., Wemhöner K., Rinné S., Netter M.F., Zuzarte M., Aller M.I., Kaufmann S.G., Li X.T., Meuth S.G., Daut J., Sachse F.B., Maier S.K.
  (Siehe online unter https://doi.org/10.1159/000331715)
• The pore structure and gating mechanism of K2P channels. EMBO Journal Vol. 30. 2011, Issue 21, pp. 3607-3619.
  Piechotta P.L., Rapedius M., Stansfeld P.J., Bollepalli M.K., Ehrlich G., Andres-Enguix I., Fritzenschaft H., Decher N., Sansom M.S., Tucker S.J., Baukrowitz T.
  (Siehe online unter https://doi.org/10.1038/emboj.2011.369)
• Dkk3 is a component of the genetic circuitry regulating aldosterone synthesis in the adrenal cortex. Human Molecular Genetics, Vol. 21. 2012, Issue 22, 15 pp. 4922–4929.
  El Wakil A., Bandulik S., Guy N., Bendahhou S., Zennaro M.C., Niehrs C., Mari B., Warth R., Barhanin J., Lalli E.
  (Siehe online unter https://doi.org/10.1093/hmg/dds333)
• Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmachertherapie & Elektrophysiologie, Vol. 23. 2012, pp. 211–219.
  Zumhagen S., Stallmeyer B., Friedrich C., Eckardt L., Seebohm G., Schulze-Bahr E.
  (Siehe online unter https://doi.org/10.1007/s00399-012-0232-8)
• State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels, Vol. 6. 2012, Issue 6, pp. 473-478.
  Rapedius M., Schmidt M.R., Sharma C., Stansfeld P.J., Sansom M.S., Baukrowitz T., Tucker S.J.
  (Siehe online unter https://doi.org/10.4161/chan.22153)
• Alterations of N-3 Polyunsaturated Fatty Acid-Activated K2P Channels in Hypoxia-Induced Pulmonary Hypertension. Basic & clinical pharmacology & toxicology, Vol. 113. 2013, Issue 4, pp. 250-258.
  Nielsen G., Wandall-Frostholm C., Sadda V., Olivan-Viguera A., Lloyd E.E., Bryan R.M., Jr., Simonsen U., Kohler R.
  (Siehe online unter https://doi.org/10.1111/bcpt.12092)
• Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology, Vol. 154. 2013, Issue 8, pp. 2712–2722.
  Bandulik S., Tauber P., Penton D., Schweda F., Tegtmeier I., Sterner C., Lalli E., Lesage F., Hartmann M., Barhanin J., Warth R.
  (Siehe online unter https://doi.org/10.1210/en.2013-1101)
• The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. Cardiovascular Research, Vol. 97. 2013, Issue 1, pp. 97–105.
  Schiekel J., Lindner M., Hetzel A., Wemhöner K., Renigunta V., Schlichthörl G., Decher N., Oliver D., Daut J.
  (Siehe online unter https://doi.org/10.1093/cvr/cvs285)
• Breaking the silence: functional expression of the two-pore-domain potassium channel THIK-2. Pflügers Archiv - European Journal of Physiology, Vol. 466. 2014, pp. 1735–1745.
  Renigunta V., Zou X., Kling S., Schlichthörl G., Daut J.
  (Siehe online unter https://doi.org/10.1007/s00424-013-1404-z)
• Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nature Communications, Vol. 5. 2014, Article number: 5540.
  Wilke B.U., Lindner M., Greifenberg L., Albus A., Kronimus Y., Bünemann M., Leitner M.G., Oliver D.
  (Siehe online unter https://doi.org/10.1038/ncomms6540)
• Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. Journal of Physiology, Vol. 593. 2015, Issue 1, pp. 127-144.
  Bista P., Pawlowski M., Cerina M., Ehling P., Leist M., Meuth P., Aissaoui A., Borsotto M., Heurteaux C., Decher N., Pape H.C., Oliver D., Meuth S.G., Budde T.
  (Siehe online unter https://doi.org/10.1113/jphysiol.2014.276527)
• Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1081–1090.
  Kiper A.K., Rinné S., Rolfes C., Ramirez D., Seebohm G., Netter M.F., Gonzalez W., Decher N.
  (Siehe online unter https://doi.org/10.1007/s00424-014-1665-1)
• TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. Journal of Molecular and Cellular Cardiology, Vol. 81. 2015, pp. 71-80.
  Rinné S., Kiper A.K., Schlichthörl G., Dittmann S., Netter M.F., Limberg S.H., Silbernagel N., Zuzarte M., Moosdorf R., Wulf H., Schulze-Bahr E., Rolfes C., Decher N.
  (Siehe online unter https://doi.org/10.1016/j.yjmcc.2015.01.017)
• The role of protein-protein interactions in the intracellular traffic of the potassium channels TASK-1 and TASK-3. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, pp. 1105–1120.
  Kilisch M., Lytovchenko O., Schwappach B., Renigunta V., Daut J.
  (Siehe online unter https://doi.org/10.1007/s00424-014-1672-2)
• The role of two-pore-domain background K⁺ (K₂p) channels in the thalamus. Pflügers Archiv - European Journal of Physiology, Vol. 467. 2015, Issue 5. pp. 895–905.
  Bista P., Cerina M., Ehling P., Leist M., Pape H.C., Meuth S.G., Budde T.
  (Siehe online unter https://doi.org/10.1007/s00424-014-1632-x)