Infection Biology and Epidemiology of Staphylococci and Staphylococcal Diseases in South and Central Afrika

• Applicants: Professor Dr. Hagen von Briesen; Professor Dr. Mathias Herrmann; Professor Dr. Winfried V. Kern; Professor Dr. Alexander Mellmann, since 12/2010; Professor Dr. Georg Peters, since 9/2009 (†)
• Co-Applicants: Salim Abdulla, Ph.D.; Professor Dr. Martin Grobusch; Professor Dr. Thomas Hänscheid; Dr. Saadou Issifou; Inacio Mandomando, Ph.D.
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2009 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 68523460

Staphylococcus aureus continues to be a major pathogen causing invasive disease with high associated morbidity and mortality. The pathogen has acquired resistance against virtually all antimicrobials available, and in the recent years, the worldwide emergence of multiresistant S. aureus clones in hospitals and communities has spurred significant concern for local and global health initiatives. In contrast to the ‘classical’ tropical diseases, however, almost nothing is known on the strain phylogeny and prevalence, disease type, and associated morbidity and mortality of infections due to S. aureus in most African countries. This proposal submitted by four sub-Saharan African and five German groups thus focusses on a registry of S. aureus community-acquired disease, on the isolation and characterization of clinical isolates with advanced methods for typing and virulence factor expression, and on GLP-conform long-term isolate handling and scientific database exchange. Emerging information will allow to associate S. aureus biology with course of disease, and thus provide a basis for future rational multifaceted interventions including diagnostics, therapy, and preventive measures tailored to the resources and requirements of sub- Saharan Africa. Moreover, the applied academic exchange and workshop program as well as case ascertainment and isolate characterization based on shared criteria and techniques will foster the combat against this pathogen in African countries as well as in Germany.

• DFG Programme: Research Grants
• International Connection: Cape Verde, Gabon, Mozambique, South Africa, Switzerland, Tanzania
• Participating Persons: Professor Dr. Pedro Luis Alonso; Professor Dr. Günter R. Fuhr; Professor Dr. Peter Gottfried Kremsner; Dr. Michael Käser; Professor Dr. Gerd Pluschke
• Ehemalige Antragsteller: Professor Dr. Christof von Eiff, until 9/2009; Professor Dr. Alexander W. Friedrich, until 12/2010