Monocyte and macrophage subsets in liver fibrogenesis ((2)-P09)

• Subject Area: Gastroenterology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 36842431

Sustained inflammation upon chronic liver injury induces the development of fibrosis. Using mouse models and human samples, we investigate functional contributions of monocyte/ macrophage subpopulations in the progression and regression of liver fibrosis and explore novel strategies for targeting monocyte/macrophage subsets in hepatic fibrogenesis for future therapeutic approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 57: Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professor Dr. Frank Tacke, Ph.D.