Project Details
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GRK 1273:  Strategies of Human Pathogens to Establish Acute and Chronic Infections

Subject Area Microbiology, Virology and Immunology
Term from 2006 to 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 969236
 
Final Report Year 2016

Final Report Abstract

Infections by pathogenic bacteria and viruses remain among the most important causes of human mortality and death worldwide. The International Research Training Group IRTG 1273 was jointly established in 2006 by Hannover Medical School (MHH), the Helmholtz Institute for Infection Biology (HZI) and their Swedish partner institution, the Karolinska Institutet, a medical university with world-wide recognition in the field of infection research. The mission of IRTG 1273 was to provide young researchers with the opportunity to perform their Ph.D. thesis in the rapidly moving field of the infection biology of human microbial pathogens in a highly stimulating, competitive, international environment. The core element of the programme was a joint research programme centering on the question how human microbial pathogens achieve acute or persistent infection and how the host organism reacts to persistent infection. Rather than focussing on one selected aspect of infection biology, multiple thematic foci have been selected with the goal of exposing the graduate students to the wide spectrum of modern infectious disease research, and taking advantage of the full breadth of faculty competence available at the three institutions involved in this IRTG. A key element of the IRTG 1273 training strategy was a mobility phase where graduate students spent time in laboratories at the partner institutions. A total of 41 exchange visits took place during the reporting period, amounting to a combined length of 99 months. Since September 1, 2006, when the first seven graduate students started their projects, a total of 44 DFG-funded graduate students plus 18 non-funded graduate students were trained in IRTG 1273. At the time of this report, 30 of the DFG-funded graduate students have obtained a PhD or Dr. rer. nat. degree, the remaining graduate students are expected to complete their doctoral training until the end of 2017. From the start until the completion of this report (end of July 2016), the DFG-funded graduate students of the IRTG have published 150 scientific papers, of which 29 are jointly authored by German and Swedish scientists. These include publications in Blood, Cell Host Microbe, EMBO Mol. Med., Gastroenterology, Gut, J. BacterioL, J. Exp. Med., J. Immunol., J. Infect. Dis., J. Virol., MBio, Nat. Commun., Nat. Immunol., PLoS Pathogens, PNAS, Cell. Microbiol., and many other leading microbiology and immunology journals. The IRTG 1273 graduate students have made important progress in answering questions regarding the strategies that human pathogens use to establish and maintain infections in humans. Due to the breadth of the programme, only few examples can be highlighted in this Summary. Important discoveries included i) the demonstration of the impact of the gastrointestinal microbiota on the diversification of the IgA antibody repertoire in the gut, ii) elucidation of the mechanisms generating genetic diversity during chronic infection with the carcinogenic stomach pathogen, Helicobacter pylori, iii) identification of several novel important mechanisms used by humans to control infection with Hepatitis C virus, iv) role of natural killer cells in different bacterial and viral infections, such as hepatitis C, Streptococcus pneumoniae. Yersinia spp., Listeria monocytogenes, and others. The graduate students benefitted greatly from the complementary skills available in the German and Swedish groups. One particularly successful example were multiple collaborations between groups at the Karolinska Institutet with a focus on human and mouse natural killer cells and groups in Germany with expertise in specific infection systems. The collaboration of these groups and the exchange of graduate students helped to develop a research cluster studying the role of NK cells in diverse human infectious diseases that has been exceptionally productive, resulting in many high-impact publications. Overall, IRTG 1273 has been a major success that achieved all goals that the partner institutions had set forth at the beginning of the project. Many of the collaborations initiated as part of IRTG 1273 will continue past the end of the IRTG 1273 funding period, and many long-lasting scientific friendships have developed, both between graduate students of the three different generations and between faculty members.

Publications

  • 2006. Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol. 7:R54
    Pfoertner, S., A. Jeron, M. Probst-Kepper, C. A. Guzman, W. Hansen, A. M. Westendorf, T. Toepfer, A. J. Schrader, A. Franzke, J. Buer, R. Geffers
  • 2007. [Application monitoring of the use of sorafenib in papillary renal cell carcinoma.] Urologe A. 46(9):1291. German
    Schrader, A. J. , A. Hegele, P. Olbert, J. Buer, A. Jeron, R. Hofmann
  • 2007. A comprehensive proteome map of the lipid-requiring nosocomial pathogen Corynebacterium jeikeium K411. Proteomics. 7:1076-96
    Hansmeier, N., T. C. Chao, S. Daschkey, M. Müsken, J. Kalinowski, A. Pühler, A. Tauch
  • 2007. A pegylated derivative of alpha-galactosytceramide exhibits improved biological properties. J. Immunol. 179:2065-73
    Ebensen, T., C. Link, P. Riese, K. Schulze, M. Morr, C. A. Guzmán
  • 2007. Solitary intestinal lymphoid tissue provides a productive port of entry for Salmonella entetica serovar Typhimurium. Infect. Immun. 75:1577-85
    Halle. S., D. Bumann, H. Herbrand, Y. Willer, S. Dähne, R. Förster, O. Pabst
  • 2007. The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant. Clin. Vaccine Immunol. 14:952-8
    Ebensen, T., K. Schulze, P. Riese, M. Morr, C. A. Guzmán
  • 2007. The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties. Vaccine. 25:1464-1469
    Ebensen, T., K. Schulze, P. Riese, C. Link, M. Morr, C. A. Guzmán
  • 2008. Developmental switch of intestinal antimicrobial peptide expression. J. Exp. Med. 205:183-93
    Ménard, S., V. Förster, M. Lotz, D. Gütle, C. U. Duerr, R. L. Gallo, B. Henriques-Normark, K. Pütsep, M. Andersson, E. O. Glocker, M. W. Hornef
  • 2008. Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J. Immunol. 180:2196-2203
    Berberich, S., S. Dähne, A. Schippers. T. Peters, W. Müller, E. Kremmer, R. Förster, O. Pabst
  • 2008. SOCS-1 protects against Chlamydia pneumoniae-induced lethal inflammation but hampers effective bacterial clearance. J. Immunol. 180:4040-9
    Yang, T., P. Stark, K. Janik, H. Wigzell, M. E. Rottenberg
  • 2009. Adenosine and IFN-alpha synergistically increase IFN-(gamma) production of human NK cells. J. Leukoc. Biol. 85:452-61
    Jeffe, F., K. A. Stegmann, F. Broelsch, M. P. Manns, M. Cornberg, H. Wedemeyer
  • 2009. Effect of peptide pools on effector functions of antigen-specific CD8+ T cells. J. Immunol. Methods. 342:33-48
    Suneetha, P. V., V. Schlaphoff, C. Wang, K. A. Stegmann, P. Fytili, S. K. Sarin, M. P. Manns, M. Cornberg, H. Wedemeyer
  • 2009. Frequency and gene expression profile of regulatory T cells in renal cell carcinoma. Tumour Biol. 30:160-70
    Jeron, A., S. Pfoertner, D. Bruder, R. Geffers, P. Hammerer, R. Hofmann, J. Buer, A. J. Schrader
  • 2009. GARP: a key receptor controlling FOXP3 in human regulatory T cells. J. Cell. Mol. Med. 13(9B):3343-57
    Probst-Kepper, M., R. Geffers, A. Kröger, N. Viegas, C. Erck, H. J. Hecht, H. Lünsdorf, R. Roubin, D. Moharregh-Khiabani, K. Wagner, F. Ocklenburg, A. Jeron, H. Garritsen, T. P. Arstila, E. Kekäläinen, R. Balling, H. Hauser, J. Buer, S. Weiss
  • 2009. Gene expression signatures of peripheral CD4+ T cells clearly discriminate between patients with acute and chronic hepatitis B infection. Hepatology. 49:781-90
    Trehanpati, N., R. Geffers, Sukriti, S. Hissar, P. Riese, T. Toepfer, J. Buer, M. Kumar, C. A. Guzman, S. K. Sarin
  • 2009. Genetic determinants of Pseudomonas aeruginosa biofilm establishment. Microbiology. 156(Pt 2):431-41
    Müsken, M., S. Di Fiore, A. Dötsch. R. Fischer, S. Haussler
  • 2009. Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS ONE. 4:e4840
    Stegemann, S., S. Dahlberg, A. Kröger, M. Gereke, D. Bruder, B. Henriques-Normark, M. Gunzer
  • 2009. Internalization-dependent recognition of Mycobacterium avium ssp. paratuberculosis by intestinal epithelial cells. Cell. Microbiol. 11:1802-15
    Pott, J., T. Basler, C. U. Duerr, M. Rohde, R. Goethe, M. W. Hornef
  • 2009. Intrahepatic long­ term persistence of parvovirus B19 and its role in chronic viral hepatitis. J. Med. Virol. 81:2079-88
    Wang, C., A. Heim, V. Schlaphoff, P. V. Suneetha, K. A. Stegmann, H. Jiang, M. Krueger, P. Fytili, T. Schulz, M. Cornberg, R. Kandolf, M. P. Manns, C. T. Bock, H. Wedemeyer
  • 2009. Is the Epstein-Barr virus EBNA-1 protein an oncogen? Proc. Natl. Acad. Sci. USA. 106:2091-2
    Schulz, T. F., S. Cordes
  • 2009. Mesenteric lymph nodes confine dendritic cell-mediated dissemination of Salmonella enterica serovar Typhimurium and limit systemic disease in mice. Infect. Immun. 77:3170-80
    Voedisch, S. C. Koenecke, S. David, H. Herbrand, R. Förster, M. Rhen, O. Pabst
  • 2009. Nonhematopoietic cells control the outcome of infection with Listeria monocytogenes in a nucleotide oligomerization domain 1-dependent manner. Infect. Immun. 77:2908-18
    Mosa, A., C. Trumstedt, E. Eriksson, O. Soehnlein, F. Heuts, K. Janik, A. Klos, O. Dittrich-Breiholz, M. Kracht, A. Hidmark, H. Wigzell, M. E. Rottenberg
  • 2009. O-antigen delays lipopolysaccharide recognition and impairs antibacterial host defense in murine intestinal epithelial cells. PLoS Pathog. 5:e1000567
    Duerr, C. U., S. F. Zenk, C. Chassin, J. Pott, D. Gütle, M. Hensel, M. W. Hornef
  • 2009. Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol. Med. 1:211-22
    Littmann, M., B. Albiger, A. Frentzen, S. Normark, B. Henriques-Normark, L. Plant
  • 2009. The roles of the nitrate reductase NarGHJI, the nitrite reductase NirBD and the response regulator GInR in nitrate assimilation of Mycobacterium tuberculosis. Microbiology. 155:1332-9
    Malm. S., Y. Tiffert, J. Micklinghoff, S. Schultze, I. Joost, I. Weber, S. Horst, B. Ackermann, M. Schmidt, W. Wohlleben, S. Ehlers, R. Geffers, J. Reuther, F. C. Bange
  • 2010. A 96-well plate based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application for susceptibility testing. Nat. Protoc. 5:1460-1469
    Müsken, M., S. Di Fiore, U. Römling, S. Häussler
  • 2010. Actin reorganization induced by Chlamydia trachomatis Serovar D - Evidence for a critical role of the effector protein CT166 targeting Rac. PLoS ONE. 5:e9887
    Thalmann, J., K. Janik, M. May, K. Sommer, J. Ebeling, F. Hofmann, H. Genth, A. Klos
  • 2010. Adaptation of hepatitis C virus to mouse CD81 permits infection of mouse cells in the absence of human entry factors. PLoS Pathog. 6(7):e1000978
    Bitzegeio, J., D. Bankwitz, K. Hueging, S. Haid, C. Brohm, M.B. Zeisel, E. Hermann, M. Iken, M. Ott, T.F. Baumert, T. Pietschmann
  • 2010. Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunol. 4(3):325:34
    Duerr, C. U., N. H. Saizman, A. Dupont, A. Szabo, B. H. Normark, S. Normark, R. M. Locksley, P. Mellroth, M. W. Hornef
  • 2010. Expression patterns of NKG2A, KIR and CD57 define a process of CD56dim NK cell differentiation uncoupled from NK cell education. Blood 116(19):3853-64
    Björkström, N.K., P. Riese, F. Heuts, S. Andersson, C. Fauriat, M. A. Ivarsson, A. T. Björklund, M. Flodström-Tullberg, J. Michaëlsson, M. E. Rottenberg, C. A. Guzmán, H.-G. Ljunggren, K.-J. Malmberg
  • 2010. Global genotypephenotype correlations in Pseudomonas aeruginosa. PLoS Pathog. 6(8):e1001074
    Pommerenke, C., M. Müsken, T. Becker, A. Dötsch, F. Klawonn, S. Häussler
  • 2010. Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53. Int. J. Med. Microbiol. 301 (3):213-24
    Coombs N., R. Sompallae, P. Olbermann, S. Gastaldello, D. Göppel, M.G. Masucci, C. Josenhans
  • 2010. Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site and protects conserved neutralizing epitopes. J. Virol. 84(11):5751-63
    Bankwitz, D., E. Steinmann, J. Bitzegeio, S. Ciesek, M. Friesland, E. Hermann, M. B. Zeisel, T. F. Baumert, Z. Keck, S. K. H. Foung, E. I. Pécheur, T. Pietschmann
  • 2010. Interferon-α-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology. 138:1885-1897
    Stegmann, K. A., N. K. Björkström. H. Veber, S. Ciesek, P. Riese, J. Wiegand, J. Hadem, P. V. Suneetha, J. Jaroszewicz, C. Wang, V. Schlaphoff, P. Fytili, M. Cronberg, M. P. Manns, R. Geffers, T. Pietschmann, C. A. Guzmán, H. G. Ljunggren, H. Wedemeyer
  • 2010. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe. 8(4):358-88
    Chassin, C., M. Kocur, J. Pott, C. U. Duerr, D. Gütle, M. Lotz, M. W. Hornef
  • 2010. Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog. 6(4):e100087
    Bruns, S., O. Kniemeyer, M. Hasenberg, V. Aimanianda, S. Nietzsche, A. Thywissen, A. Jeron, J. P. Latgé, A. A. Brakhage, M. Gunzer
  • 2010. Thiol peroxidase (Tpx) protects Salmonella enterica from hydrogen peroxide stress in vitro and facilitates intracellular growth. J. Bacteriol. 192(11):2929-32
    Horst, S. A., T. Jaeger, L. Denkel, S. F. Rouf, M. Rhen, F. C. Bange
  • 2011. Comparative analysis of Ebola virus glycoprotein interactions with human and bat cells. J. Infect. Dis. 204 SuppI 3:S840-9
    Kühl, A., M. Hoffmann, M. A. Müller, V. J. Munster, K. Gnirss, M. Kiene, T.S. Tsegaye, G. Behrens, G. Herder, H. Feldmann, C. Drosten, S. Pöhlmann
  • 2011. Completion of Hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog. 7(4):e1002029
    Frentzen, A., K. Hüging, J. Bitzegeio, M. Friesland, S. Haid, J. Gentzsch, M. Hoffmann, D. Lindemann, G. Zimmer, F. Zielecki, F. Weber, E. Steinmann, T. Pietschmann
  • 2011. Deletion of Kaposi's sarcoma herpesvirus FLICE inhibitory protein (vFLIP) from the viral genome compromises the activation of STAT-1 responsive cellular genes and spindle cell formation in endothelial cells. J. Virol. 85(19):10375-88
    Alkharsah, K. R., W. Singh, R. Bosco, S. Santag, A. Grundhoff, A. Konrad, M. StürzI, D. Wirth, O. Dittrich-Breiholz, M. Kracht, TF. Schulz
  • 2011. Dissemination of persistent intestinal bacteria via the mesenteric lymph nodes causes typhoid relapse. Infect. Immun. 79(4):1479-88
    Griffin, A. J., L. X. Li, S. Voedisch, O. Pabst, S. J. McSorley
  • 2011. Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells. PLoS Pathog. 7(5):e1002045
    Schlaphoff, V., S. Lunemann, P.V. Suneetha, J. Jaroszewicz, J. Grabowski, J. Dietz. F. Helfritz, H. Bektas, C. Sarrazin, M.P. Manns, M. Cornberg, H. Wedemeyer
  • 2011. Gene expression profiles of T cells from hepatitis E virus infected patients in acute and resolving phase. J. Clin. Immunol. 31(3):498-508
    TrehanPati, N., S. Sukriti, R. Geffers, S. Hissar, P. Riese, T. Toepfer, C.A. Guzman, S.K. Sarin
  • 2011. Helicobacter pylori genome evolution during human infection. Proc. Natl. Acad. Sci. USA. 108(12):5033-8
    Kennemann, L., X. Didelot, T. Aebischer, S. Kuhn, B. Drescher, M. Droege, R. Reinhardt, P. Correa, T. F. Meyer, C. Josenhans, D. Falush, S. Suerbaum
  • 2011. IFN-λ determines the intestinal epithelial antiviral host defense. Proc. Natl. Acad. Sci. USA. 108(19):7944-9
    Pott, J., T. Mahlaköiv, M. Mordstein, C.U. Duerr, T. Michiels, S. Stockinger, P. Staeheli, MW Hornef
  • 2011. Methionine sulfoxide reductases are essential for virulence of Salmonella Typhimurium. PLoS 6(11):e26974
    Denkel, L. A., S. A. Horst, S. F. Rouf, V. Kitowski, O. M. Böhm, M. Rhen, T. Jäger, F.-C. Bange
  • 2012. A new role of the complement system, C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One. 7(11):e50327
    Bode, J., P. Dutow, K. Sommer, K. Janik, S. Glage, B. Tümmler, A. Munder, R. Laudeley, K. Sachse, A. Klos
    (See online at https://doi.org/10.1371/journal.pone.0050327)
  • 2012. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology. 143:213-222 e215
    Haid, S., A. Novodomska, J. Gentzsch, C. Grethe, S. Geuenich, D. Bankwitz, P. Chhatwal, B. Jannack. T. Hennebelle. F. BailleuI, O. T. Keppler, M. Poenisch, R. Bartenschlager, C. Hernandez, M. Lemasson, A. R. Rosenberg, F. Wong-Staal, E. Davioud-Charvet, T. Pietschmann
    (See online at https://doi.org/10.1053/j.gastro.2012.03.036)
  • 2012. Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathog. 8(5):e1002670
    Pott, J., S. Stockinger, N. Torow, A. Smoczek, C. Lindner, G. Mclnemey, F. Bäckhed, U. Baumann, O. Pabst, A. Bleich, M. W. Hornef
    (See online at https://doi.org/10.1371/journal.ppat.1002670)
  • 2012. An orphan sensor kinase controls quinolone signal production via MexT in Pseudomonas aeruginosa. Mol. Microbiol. 83(3):536-47
    Zaoui, C., J. Overhage, D. Löns, A. Zimmermann, M. Müsken, P. Bielecki, C. Pustelny, T. Becker, M. Nimtz, S. Häussler
    (See online at https://doi.org/10.1111/j.1365-2958.2011.07947.x)
  • 2012. Bile acids specifically increase hepatitis C virus RNA-replication. PLoS One. 7(4):e36029
    Chhatwal, P., D. Bankwitz, J. Gentzsch, A. Frentzen, P. Schult, V. Lohmann, T. Pietschmann
    (See online at https://doi.org/10.1371/journal.pone.0036029)
  • 2012. ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells. BMC Genomics. 13:705
    Jeron, A., W. Hansen, F. Ewert, J. Buer, R. Geffers, D. Bruder
    (See online at https://doi.org/10.1186/1471-2164-13-705)
  • 2012. Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3. Chemistry. 18(3):880-6
    Taft, F., K. Harmrolfs, I. Nickeleit, A. Heutling, M. Kiene, N. Malek, F. Sasse, A. Kirschning
    (See online at https://doi.org/10.1002/chem.201101640)
  • 2012. Escape from a dominant HLA-B*15-restricted CD8+ T cell response against hepatitis C virus requires compensatory mutations outside the epitope. J. Virol. 86:991-1000
    Ruhl, M., P. Chhatwal, H. Strathmann, T. Kuntzen, D. Bankwitz, K. Skibbe, A. Walker, F. M. Heinemann, P. A. Horn, T. M. Allen, D. Hoffmann, T. Pietschmann, J. Timm
    (See online at https://doi.org/10.1128/JVI.05603-11)
  • 2012. First insight into the kinome of human regulatory T cells. PLoS One. 7(7):e40896
    König, S., M. Probst-Kepper, T. Reinl, A. Jeron, J. Huehn, B. Schraven, L. Jänsch
    (See online at https://doi.org/10.1371/journal.pone.0040896)
  • 2012. Genome sequence of Helicobacter pylori hpEurope Strain N6. J. Bacteriol. 194(14):3725-6
    Behrens, W., T. Bönig, S. Suerbaum, C. Josenhans
    (See online at https://doi.org/10.1128/JB.00386-12)
  • 2012. Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication. Gastroenterology. 143(2):439-47
    von Hahn. T., C. Schiene-Fischer, N.D. Van, S. Pfaender, B. Karavul, E. Steinmann, A. Potthoff, C. Strassburg, N. Hamdi, A. I. Abdelaziz, C. Sarrazin, T. Müller, T. Berg, E. Trépo, H. Wedemeyer, M.P. Manns, T. Pietschmann, S. Ciesek
    (See online at https://doi.org/10.1053/j.gastro.2012.04.053)
  • 2012. In vivo sequence variation in HopZ, a phase variable outer membrane protein of Helicobacter pylori. Infect. Immun. 80(12):4364-73
    Kennemann, L., B. Brenneke, S. Andres, L. Engstrand, T. F. Meyer, T. Aebischer, C. Josenhans, S. Suerbaum
  • 2012. Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent expression in infected cells. PLoS One. 7(8):e43337
    Winkler, M., S. Bertram, K. Gnirß, I. Nehlmeier, A. Gawanbacht, F. Kirchhoff, C. Ehrhardt, S. Ludwig, M. Kiene, A S. Moldenhauer, U. Goedecke, C.B. Karsten, A. Kühl, S. Pöhlmann
    (See online at https://doi.org/10.1371/journal.pone.0043337)
  • 2012. Interferon α-stimulated natural killer cells from patients with acute Hepatitis C Virus (HCV) infection recognize HCV-infected and uninfected hepatoma cells via DNAX accessory molecule-1. J. Infect. Dis. 205(9): 1351-62
    Stegmann, K. A., N. K. Björkström, S. Ciesek, S. Lunemann, J. Jaroszewicz, J. Wiegand, P. Malinski, L. B. Dustin, C. M. Rice, M. P. Manns, T. Pietschmann, M. Cornberg, H.G. Ljunggren, H. Wedemeyer
    (See online at https://doi.org/10.1093/infdis/jis210)
  • 2012. Kinome analysis of receptor-induced phosphorylation in human natural killer cells. PLoS One. 7(1):e29672
    König, S., M. Nimtz, M. Scheiter, H.G. Ljunggren, Y.T. Bryceson, L. Jänsch
    (See online at https://doi.org/10.1371/journal.pone.0029672)
  • 2012. MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious Hepatitis C virus particles. PLoS Pathog. 8(7):e1002829
    Menzel, N., W. Fischl, K. Hueging, D. Bankwitz, A. Frentzen, S. Raid, J. Gentzsch, L. Kaderali, R. Bartenschlager, T. Pietschmann
    (See online at https://doi.org/10.1371/journal.ppat.1002829)
  • 2012. NK cells in hepatitis C: role in disease susceptibility and therapy. Dig. Dis. 30 Suppl 1:48-54
    Lunemann, S., V. Schlaphoff, M. Cornberg, H. Wedemeyer
  • 2012. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarkoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 32(32):3676-85
    Santag, S., W. Jäger, C.B. Karsten, S. Kati, M. Pietrek, D. Steinemann, G. Sarek, P.M. Ojala, T.F. Schulz
    (See online at https://doi.org/10.1038/onc.2012.385)
  • 2012. Rhadinoviruses: KSHV and associated malignancies. In: Cancer associated viruses. Robertson E.S. (Ed.). Springer Science + Business Media. New York, pp. 215-249
    Santag, S., T.F. Schulz
  • 2012. Structural basis for intrinsic thermosensing by the master virulence regulator RovA of Yersinia. J. Biol. Chem. 287(43):35796-803
    Quade, N., C. Mendonca, K. Herbst, A. K. Heroven, C. Ritter, D. W. Heinz, P. Dersch
    (See online at https://doi.org/10.1074/jbc.M112.379156)
  • 2012. The mammalian intestinal epithelium as integral player in the establishment and maintenance of host-microbial homeostasis. Semin. Immunol. 24(1):25-35
    Duerr, C. U., M. W. Hornef
    (See online at https://doi.org/10.1016/j.smim.2011.11.002)
  • 2012. The nucleotide excision repair (NER) system of Helicobacter pylori: Role in mutation prevention and chromosomal import patterns after natural transformation. BMC Microbiol. 12(1):67
    Moccia, C., J. Krebes, S. Kulick, X. Didelot, C. Kraft, C. Bahlawane, S. Suerbaum
    (See online at https://doi.org/10.1186/1471-2180-12-67)
  • 2012. The role of the alternative coreceptor GPR15 in SIV tropism for human cells. Virology. 433(1 ):73-84
    Kiene, M., A. Marzi, A. Urbanczyk, S. Bertram, T. Fisch, I. Nehlmeier, K. Gnirß, C.B. Karsten. D. Palesch, J. Münch, F. Chiodi, S. Pöhlmann, I. Steffen
    (See online at https://doi.org/10.1016/j.virol.2012.07.012)
  • 2012. The ubiquitin-specific protease USP7 modulates the replication of Kaposi's Sarcoma Herpesvirus latent episomal DNA. J. Virol. 86(12):6745-57
    Jäger, W., S. Santag, M. Weidner-Glunde, E. Gellermann, S. Kati, M. Pietrek, A. Viejo-Borbolla, T. F. Schulz
    (See online at https://doi.org/10.1128/JVI.06840-11)
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