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SFB 854:  Molecular Organisation of Cellular Communications within the Immune System

Subject Area Medicine
Term from 2010 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925
 
Final Report Year 2022

Final Report Abstract

During the 12.5 years of funding by the DFG, the primary goal of the Collaborative Research Center 854 "Molecular organization of cellular communication in the immune system" was to decode central processes of intra- and intercellular communication in the immune system with the help of state of the art biochemical, cell biological and molecular biology technologies. Findings from the locally established discipline of "Molecular Neurobiology" and, especially in the context of the first funding period, also from “Systems Biology” flowed into the research program of CRC854. From the results obtained, CRC854 expected a deeper understanding of the molecular regulatory mechanisms underlying physiological and pathophysiological processes within the immune system. In addition to the scientific findings, significant impulses for the further development of the research landscape in Magdeburg and Saxony-Anhalt were expected from the establishment of CRC854. With regard to the scientific knowledge gained, CRC854 achieved the goals set by the SFB board in all three funding periods. In addition, the CRC854 was able to set crucial impulses in the area of local and regional structure formation. With the founding of the "Health Campus Immunology, Infectiology and Inflammation (GC-I3)" in 2014, the "Institute for Inflammation and Neurodegeneration (IIN)" in 2016, the establishment of the master's program "Immunology" in 2017, the Imaging Core Facility "Multiparametric Bioimaging and Cytometry (MPBIC)" in 2018 and the founding of the cross-faculty research center "Center for Health and Medical Prevention (CHaMP)" in 2021, CRC854 executed a significant structure-forming effect within university medicine, and beyond on the level of the OVGU and the State of Saxony-Anhalt. Furthermore, the W2 professorships "Intravital Imaging/Experimental Immunodynamics" and "Immunoregulation" were established during the second funding period at the Institute of Molecular and Clinical Immunology (IMKI) and have become vital assets in the SFB854. The same already applies to the recently established W1 professorship in “Immune Metabolism” (tenure track to W2). These scientific and structure-forming successes over the last 18.5 years (6 years FOR521 and 12.5 years SFB854) form the basis for the medical faculty of the OVGU, as well as for closely associated other faculties and non-university research institutions, to develop an internationally competitive strategy for its research focus on "Immunology and Molecular Medicine of Inflammation” and within the „Center for Health and Medical Prevention (CHaMP)“. This strategy will necessarily take both the increasingly dynamic research in the clinical-translational field as well as the current developments in the new curriculum for our future physicians (Neue Ärztliche Approbationsordnung) into account. First steps in this direction were taken in the very recent past with the successful reappointments of the W3 professorships for "Gastroenterology", "Hematology and Oncology" and "Paediatrics"; these came also along with a profound generational change within the site. Likewise, strategic recruitments for the W3 professorship for "Molecular and Clinical Immunology" (speaker function during the 12.5-year funding period of the SFB854, spokesman function for the research group 521 that preceded the SFB854 and project B19), as well as the W3 professorships for "Biochemistry and cell biology" (TP10), "Experimental internal medicine" and "Pathology" will take place in the next two years. These are of pivotal interest for the medical faculty and will further expand and strengthen its research foci.

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