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Institution
Max-Planck-Institut für molekulare Genetik (MPIMG)
Address
Ihnestraße 63-73
14195 Berlin
Deutschland
GERiT
This institution in GERiT
14195 Berlin
Projects
Research Grants
Current projects
Elucidate the functions of the BET bromodomain protein BRD4 in co-transcriptional splicing
(Applicant
Mayer, Andreas
)
Mechanisms of transcription elongation control by the biomolecular condensate forming BET family protein BRD4
(Applicant
Mayer, Andreas
)
Reversibility of SCA2/ALS13: Contribution of cell types, in conditional mice
(Applicant
Auburger, Georg
)
Completed projects
Alu-bindende Proteine in der Kontrolle der Genexpression
(Applicant
Schweiger, Manfred
)
Datenintegration, Pathwayanalyse und Modellierung
(Applicant
Herwig, Ralf
)
Development of a software for the integrative analysis of DNA copy number changes
(Applicant
Ullmann, Reinhard
)
Die Wirkung von Ataxin-2-Defizienz bzw. -Überexpression auf mRNA-3'-Prozessierung und stress granules in Hefe, Maus und Mensch
(Applicants
Auburger, Georg
;
Krobitsch, Sylvia
)
Differentielle Genexpression in Zellen des Synovialgewebes bei entzündlichen und nichtentzündlichen Gelenkerkrankungen
(Applicant
Häupl, Thomas
)
DNA-computing
(Applicant
Reisig, Wolfgang
)
DNA-Substraterkennung durch Typ-III-Restriktionsendonukleasen
(Applicant
Krüger, Detlev H.
)
Entwicklung einer Diagnostik für die Kristallisation biologischer Makromoleküle
(Applicant
Saenger, Wolfram
)
Genetic and molecular dissection of signalling pathways causing non-mendelian inheritance in the mouse
(Applicant
Herrmann, Bernhard G.
)
Long-read sequencing of SF3B1 mutated and wildtype chronic lymphocytic leukemia and myelodysplastic syndrome to identify mechanisms of genomic instability and therapy resistance and their impact on prognosis.
(Applicants
Beyer, Andreas
;
Herwig, Ralf
;
Schweiger, Michal-Ruth
)
Rechnergestützte phylogenetische Analyse großer genomischer Abschnitte
(Applicant
Vingron, Martin
)
Regulation des Transkriptionsfaktors Yin Yang 1 durch Modifikation mit Poly(ADR-Ribose)
(Applicant
Schweiger, Manfred
)
Role and regulation of convergent antisense transcription by RNA polymerase II
(Applicant
Mayer, Andreas
)
Structural and biochemical analyses of the disproportionating isozyme 2 (DPE2)
(Applicants
Mielke, Thorsten
;
Spahn, Christian M. T.
)
Structure of the DnaA and its interaction with DNA
(Applicant
Messer, Walter
)
Strukturelle und funktionelle Untersuchungen des Escherichia coli Ribosoms bei "quasi atomarer" Auflösung
(Applicant
Brimacombe, Ph.D., Richard
)
The three-dimensional structure of the bacterial ribosome; the transition to atomic revolution
(Applicant
Brimacombe, Ph.D., Richard
)
Untersuchung der stammspezifischen Inaktivierung des G90-Gens
(Applicant
Fundele, Reinald H.
)
Priority Programmes
Completed projects
Entwicklung von Algorithmen für den Vergleich und die Rekonstruktion der evolutionären Zusammenhänge von Gen- und Genomsequenzen
(Applicant
Vingron, Martin
)
X-chromosomal gekoppelte Lippen-Kiefer-Gaumenspalten: Molekulare Untersuchung durch Positionsklonierung
(Applicant
Ropers, Hans Hilger
)
Research Units
Completed projects
Bioinformatik und Modellierung
(Applicant
Herwig, Ralf
)
Research Fellowships
Completed projects
Signaltransduction and microtubule organisation: Their role in der cell morphogenesis in Drosophila melanogaster
(Applicant
Lange, Bodo Markus Hans
)
Statistische Physik von Multiple-Alignment Algorithmen
(Applicant
Arndt, Peter
)
Collaborative Research Centres
Current projects
SFB 1678: Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
(Spokesperson
Beyer, Andreas
)
Speed vs. fidelity: The role of nuclear RNA export under cellular stress
(Project Heads
Mayer, Andreas
;
Tresch, Achim
)
Completed projects
CD30 als therapeutische Zielstruktur: direkte Selektion humaner single-chain anti-CD30 Antikörper aus Immunglobulin-Genbibliotheken und Herstellung cytotoxischer T-Zellen für die Therapie von CD30-positiven Lymphomen
(Project Heads
Stein, Harald
;
Uchanska-Ziegler, Barbara
;
Walter, G.H.
)
Central Facility for Animal Model Generation and Characterization
(Project Heads
Mundlos, Stefan
;
Walther, Diego J.
)
Correlation between regulatory DNA sequences and gene expression data based on the comparative analysis of non-coding regions between human and mouse
(Project Heads
Sers, Christine
;
Vingron, Martin
)
Downstream Effects of MECP1 Mutations in Rett Syndrome and other Forms of X-linked Mental Retardation studied by cDNA Arrays
(Project Heads
Nuber, Ulrike
;
Ropers, Hans Hilger
)
Elektronenkristallographische Untersuchungen von licht-aktiviertem Rhodopsin
(Project Heads
Hofmann, Klaus Peter
;
Mielke, Thorsten
)
Functional Analysis of the MID1 gene product- a Key to an Understanding of the Clinical Variability of Opitz BBB/G Syndrome
(Project Head
Schweiger, Susann
)
Improving bone regeneration by modification of BMP-inhibition
(Project Heads
Mundlos, Stefan
;
Seemann, Petra
)
Mental retardation genes and their interaction
(Project Heads
Kalscheuer, Vera
;
Kuss, Andreas
;
Ropers, Hans Hilger
)
Molecular electron microscopy
(Project Heads
Mielke, Thorsten
;
Spahn, Christian M. T.
)
Molecular Pathology and Embryology of HOXD and BMP Related Limb Malformations
(Project Heads
Mundlos, Stefan
;
Seemann, Petra
)
Neuronale, zelluläre und molekulare Mechanismen der Gesangslernen im Vogelhirn
(Project Head
Scharff, Ph.D., Constance
)
Norrie disease (ND): Molecular Mechanisms of Pathogenesis and Modulation of Disease Serverity
(Project Head
Berger, Wolfgang
)
Protein Monoaminylation: Novel regulatory functions of monoaminergic hormones
(Project Head
Walther, Diego J.
)
SFB 515: Mechanisms of Developmental and Experience-Dependent Neural Plasticity
(Spokesperson
Menzel, Randolf
)
SFB 577: Molecular Basis of Clinical Variability in Mendelian Disorders
(Spokesperson
Mundlos, Stefan
)
SFB 618: Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems
(Spokesperson
Hammerstein, Peter
)
SFB 740: From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
(Spokespersons
Hofmann, Klaus Peter
;
Spahn, Christian M. T.
)
SFB 760: Biomechanics and Biology of Musculoskeletal Regeneration - From Functional Assessment to Guided Tissue Formation
(Spokesperson
Duda, Georg
)
Signalmechanismen bei der Segmentierung von Wirbeltieren
(Project Head
Herrmann, Bernhard G.
)
CRC/Transregios
Completed projects
Outer membrane vesicles in SARS-CoV2-bacteria co-infection
(Project Heads
Marsico, Annalisa
;
Schmeck, Bernd
;
Vingron, Martin
)
Reinhart Koselleck Projects
Completed projects
3D Genome Architecture in Congenital Disease
(Applicant
Mundlos, Stefan
)
Research Training Groups
Current projects
GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
(Spokesperson
Blüthgen, Nils
)
Completed projects
GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
(Spokesperson
Heinrich, Reinhart
)
GRK 1772: Computational Systems Biology
(Spokesperson
Klipp, Edda
)
International Research Training Groups
Completed projects
GRK 1360: Genomics and Systems Biology of Molecular Networks
(Spokesperson
Klipp, Edda
)
GRK 1631: MyoGrad - International Research Training Group for Myology
(Spokesperson
Spuler, Simone
)
GRK 2403: Dissecting and Reengineering the Regulatory Genome
(Spokesperson
Ohler, Uwe
)
Graduate Schools
Completed projects
GSC 203: Berlin-Brandenburg School for Regenerative Therapies (BSRT)
(Spokesperson
Duda, Georg
)
GSC 1091: Berlin School of Integrative Oncology (BSIO)
(Spokespersons
Na, Il-Kang
;
Schmitt, Clemens A.
)
Subinstitutions
Abteilung Bioinformatik
Abteilung Entwicklungsgenetik
Abteilung Genomregulation
Abteilung Molekulare Humangenetik (aufgelöst)
Abteilung Wirbeltier Genomics (aufgelöst)
Otto-Warburg-Laboratorien
Additional Information
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