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Ludwig-Maximilians-Universität München
Gene Center Munich

Address Feodor-Lynen-Straße 25
81377 München
Deutschland

GERiT This institution in GERiT

81377 München

Projects

Priority Programmes
- Current projects
  - Causes, consequences and correction of mitochondrial protein misfolding
    (Applicants Hartl, Franz-Ulrich ; Jae, Ph.D., Lucas )
  - Molecular mechanisms of functional liquid-liquid phase separation of Drosophila Loqs, Ago2 and dsRNA during siRNA biogenesis
    (Applicants Förstemann, Klaus ; Sattler, Michael )
- Completed projects
Research Grants
- Current projects
- Completed projects
Research Units
- Current projects
  - Chronic inflammasome activation in post-stroke recovery
    (Applicants Hornung, Veit ; Liesz, Arthur ; Schmidt-Pogoda, Antje )
  - FOR 2879: ImmunoStroke: From immune cells to stroke recovery
    (Spokesperson Liesz, Arthur )
- Completed projects
Independent Junior Research Groups
- Current projects
  - Biophysics of SMC complex function in chromosome organization and DNA repair
    (Applicant Stigler, Johannes )
Collaborative Research Centres
- Current projects
  - Detection and repair of covalent DNA-histone crosslinks
    (Project Head Stingele, Julian )
  - Effects of microparticles on aquatic model macrofauna depending on particle properties: Comparison of microplastics to natural particles
    (Project Heads Fröhlich, Thomas ; Laforsch, Christian )
  - Global-genome repair of DNA-protein crosslinks: lesion detection and pathway choice
    (Project Head Stingele, Julian )
  - Mechanisms of Regulation and Information Processing by the INO80 Remodeler
    (Project Head Hopfner, Karl-Peter )
  - Structural mechanism of MRN-ATM in DNA double-strand break signalling and processing
    (Project Head Hopfner, Karl-Peter )
  - Structural Mechanisms of MALT1 Signaling in T-Cell Differentiation and Activation
    (Project Heads Hopfner, Karl-Peter ; Lammens, Katja )
  - The role of metalloprotease activity in necroptosis driven inflammation
    (Project Head Hornung, Veit )
  - The role of the CARD8 inflammasome in controlling T cell fate
    (Project Head Hornung, Veit )
- Completed projects
  - A small RNA response at DNA ends
    (Project Head Förstemann, Klaus )
  - Central tasks of the Collaborative Research Centre SFB 646
    (Project Heads Beckmann, Roland ; Cramer, Patrick )
  - Characterization of Acto-Myosin-dependent Processes During Asymmetric Cell Division
    (Project Head Petritsch, Claudia )
  - Chromatin regulation at promoters and enhancers, a molecular-mechanistic analysis
    (Project Head Gaul, Ulrike )
  - Differential regulation of RIPK3 in tumour stroma and cancer cells
    (Project Heads Hornung, Veit ; Sun, Ph.D., Zhiqi )
  - Histo-pathological and high-dimensional molecular characterization of cells and tissues
    (Project Heads Klughammer, Ph.D., Johanna ; Steiger, Katja ; Theis, Fabian ; Weichert, Wilko )
  - Horizontal in trans signaling spreads cell autonomous immunity to bystander cells
    (Project Head Hornung, Veit )
  - Identifying and targeting escape mechanisms in AML using multispecific antibody derivatives
    (Project Heads Hopfner, Karl-Peter ; Subklewe, Marion )
  - Induction of DNA-triggered immune responses within the skin
    (Project Head Hornung, Veit )
  - Integration of cortex- and microtubule-associated proteins into the machinery which regulates mitotic spindle positioning
    (Project Head Petritsch, Claudia )
  - Mechanisms of Interferon Induction
    (Project Heads Brzo´zka, Krzysztof ; Conzelmann, Karl-Klaus )
  - Radioimmunotherapy of pancreatic cancer: combining biologically augmented radiotherapy with multi-functional release of immune checkpoints
    (Project Heads Hopfner, Karl-Peter ; Lauber, Kirsten ; Schmidt-Supprian, Marc )
  - Repair and Signaling of DNA Double-Strand Breaks in Normal and Malignant Hematopoiesis
    (Project Head Hopfner, Karl-Peter )
  - Rhabdovirus vectors: Replication and re-targeting
    (Project Head Conzelmann, Karl-Klaus )
  - SFB 594: Molecular Machines in Protein Folding and Protein Transport
    (Spokesperson Beckmann, Roland )
  - SFB 646: Networks in Genome Expression and Maintenance
    (Spokespersons Beckmann, Roland ; Cramer, Patrick )
  - SFB 1321: Modelling and Targeting Pancreatic Cancer
    (Spokesperson Schmid, Roland M. )
  - Structural basis of eukaryotic non-stop mediated mRNA decay and mammalian translation initiation
    (Project Heads Becker, Thomas ; Beckmann, Roland )
  - Structural mechanism of the activation of RIG-I by viral RNA
    (Project Head Hopfner, Karl-Peter )
  - Structural mechanism of the Swi2/Snf2 ATPases in genome expression and maintenance
    (Project Head Hopfner, Karl-Peter )
  - Struktur des proteinleitenden Kanals bei der Insertion eines polytopischen Membranproteins, des Opsins
    (Project Head Beckmann, Roland )
  - The functional architecture of the ribosome-NAC complex and its role in protein targeting
    (Project Heads Beatrix, Birgitta ; Beckmann, Roland )
  - Thermodynamic modelling of transcriptional regulation: improving input data and exploring cis-element architecture
    (Project Head Gaul, Ulrike )
  - Viral Vector Facility
    (Project Heads Conzelmann, Karl-Klaus ; Götz, Magdalena )
  - Viral vectors for circuit analyses
    (Project Head Conzelmann, Karl-Klaus )
  - Visualization of the ribosometranslocon complex: nascent transmembrane domains in the ribosomal tunnnel and the active translocon in the membrane
    (Project Head Beckmann, Roland )
Research Fellowships
- Completed projects
  - Antiviral Immunity: Molecular characterization of MDA5 und RIG-I - Ligands, interacting proteins and novel functions
    (Applicant Hornung, Veit )
CRC/Transregios
- Current projects
  - Central Infrastructure of the Collaborative Research Centre
    (Project Heads Hornung, Veit ; Klughammer, Ph.D., Johanna )
  - Central tasks of the Collaborative Research Centre
    (Project Heads Hartmann, Gunther ; Hornung, Veit )
  - Chemical biology of intracellular nucleic acid recognition
    (Project Heads Carell, Thomas ; Hornung, Veit )
  - Genomics and Bioinformatics Platform
    (Project Heads Beißbarth, Tim ; Gökçe, Özgün ; Götz, Magdalena ; Klughammer, Ph.D., Johanna ; Simons, Mikael Jakob )
  - Integrative analysis of single cell genomics and immunoprofiling
    (Project Heads Canzar, Stefan ; Theis, Fabian )
  - Phenotypic, genetic, and transcriptional dissection of type I interferonopathies – a systems approach
    (Project Heads Klughammer, Ph.D., Johanna ; Lee-Kirsch, Min Ae )
  - Structural mechanisms of self-nucleic acid sensing by cGAS
    (Project Head Hopfner, Karl-Peter )
  - Targeting T cell-intrinsic negative regulators to enhance the therapeutic potential of adoptive T cell therapy
    (Project Head Hornung, Veit )
  - The physiology and pathophysiology of aldosterone production in the pig
    (Project Heads Kemter, Elisabeth Gabriele ; Williams, Ph.D., Tracy Ann ; Wolf, Eckhard )
  - TRR 237: Nucleic Acid Immunity
    (Spokespersons Hartmann, Gunther ; Hornung, Veit )
- Completed projects
  - Contribution of cellular stress to RNA virus PAMP recognition
    (Project Head Conzelmann, Karl-Klaus )
  - Co-translational membrane targeting by SRP and FlhF
    (Project Head Beckmann, Roland )
  - Cryo-EM analysis of the ISWI chromatin remodeller ACF
    (Project Head Beckmann, Roland )
  - DNA damage response signaling mediated antiviral response
    (Project Head Hornung, Veit )
  - Functional architecture of the INO80 chromatin-remodelling complex in DNA repair
    (Project Head Hopfner, Karl-Peter )
  - Genetically engineered donor pigs with improved pancreatic islets
    (Project Heads Böttcher, Anika ; Kemter, Elisabeth Gabriele ; Klymiuk, Nikolai ; Wolf, Eckhard ; Wünsch, Annegret )
  - Mechanisms of interferon induction by hepatitis D virus and impact of chronic innate immune activation on antiviral immunity
    (Project Heads Bohne, Felix Mark ; Hornung, Veit ; Knolle, Percy Alexander )
  - Optimization of porcine neonatal islet like cell clusters for clinical transplantation therapy
    (Project Heads Bonifacio, Ph.D., Ezio ; Cohrs, Christian ; Gavalas, Ph.D., Anthony ; Kemter, Elisabeth Gabriele ; Solimena, Michele ; Speier, Stephan )
Major Research Instrumentation
- Completed projects
Clinical Research Units
- Completed projects
  - Inflammasome activiation in Alzheimer´s disease
    (Applicant Latz, Eicke )
  - Zentrales Gemeinschaftsprojekt Genomics, Proteomics, Organisation
    (Applicant Göke, Burkhard )
Research Training Groups
- Completed projects
  - GRK 1029: Functional Genome research in veterinary medicine
    (Spokesperson Kaspers, Bernd )
  - GRK 1202: Oligonucleotides in Cell Biology and Therapy
    (Spokesperson Endres, Stefan )
  - GRK 1721: Integrated Analysis of Macromolecular Complexes and Hybrid Methods in Genome Biology
    (Spokesperson Hopfner, Karl-Peter )
Clusters of Excellence
- Completed projects
  - EXC 114: Munich Center for Integrated Protein Science (CIPSM)
    (Spokesperson Carell, Thomas )
  - EXC 1023: ImmunoSensation: The Immune Sensory System
    (Spokesperson Hartmann, Gunther )
Graduate Schools
- Completed projects
  - GSC 1006: Graduate School of Quantitative Biosciences Munich (QBM)
    (Spokesperson Frey, Erwin )

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