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Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
Emil-Fischer-Zentrum
Institut für Biochemie
Address
Fahrstraße 17
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Research Grants
Current projects
Analysis of the role of Four and a half LIM domains protein 2 (FHL2) in hepatic lipid metabolisms in non-alcoholic fatty liver disease (NAFLD)
(Applicant
Hellerbrand, Claus
)
Analyzing the role of developmental programming of the adult hippocampal neurogenic niche in prenatal stress-induced vulnerability to psychiatric disease
(Applicant
Lie, Dieter Chichung
)
Assessing the functional relevance of the isomerase Pin1 for the modulation of herpesviral polymerase complexes
(Applicants
Marschall, Manfred
;
Sticht, Heinrich
)
Deciphering the molecular mechanisms controlling maturation of adult-generated hippocampal neurons
(Applicant
Lie, Dieter Chichung
)
Epigenetic regulation in myelinating glia: The role of histone H2B monoubiquitination in Schwann cells and oligodendrocytes
(Applicant
Sock, Elisabeth
)
Exploring the hook-into-groove interaction of the herpesviral nuclear egress complex in a quest towards novel anti-herpesviral inhibitors
(Applicants
Funke, Susanne Aileen
;
Muller, Yves André
;
Sticht, Heinrich
)
Functional analysis of hippocampal astrocytes in the regulation of adult neurogenesis
(Applicant
Beckervordersandforth, Ruth
)
Metabotropic glutamate receptor type 7 dimers at inner hair cell ribbon synapses of the mammalian cochlea: protection against hearing loss
(Applicant
Klotz-Weigand, Ph.D., Lisa Janina
)
Modelling, Design, and Implementation of Molecular Communication Systems - Phase 2: Media-Modulation based Molecular Communication
(Applicants
Burkovski, Ph.D., Andreas
;
Castiglione, Kathrin
;
Schober, Robert
;
Sticht, Heinrich
)
Molecular mechanisms involved in the modulation of ion channels of the ENaC/Degenerin family by amphiphilic substances
(Applicant
Härteis, Silke
)
Completed projects
Die Funktion von Sox-Transkriptionsfaktoren der Gruppe D in der Entwicklung von Nervensystem und Neuralleistenderivaten
(Applicant
Stolt, Claus
)
Die Rolle des humanen Zink Finger Proteins 2 in der Aktivierung von humanen hepatischen Sternzellen
(Applicant
Hellerbrand, Claus
)
Die Rolle von Transkriptionsfaktoren der Sox-Protein-Gruppe C in der Entwicklung des peripheren und zentralen Nervensystems
(Applicant
Sock, Elisabeth
)
Die Rolle von Wnt-Proteinen in der neuronalen und dopaminergen Differenzierung adulter neuraler Stammzellen
(Applicant
Lie, Dieter Chichung
)
Function of zinc finger protein 276 during CNS myelination and remyelination as part of the oligodendrocyte transcriptional network
(Applicant
Küspert, Melanie
)
Identification of the interactome of muscular LAP proteins, Erbin, Lano, and Scribble, their involvement in the endocytic recycling at the neuromuscular synapse, and their role in myogenesis
(Applicant
Hashemolhosseini, Said
)
In search of intra and extra cellular proteins interacting with muscle-specific kinase "MuSK"
(Applicant
Hashemolhosseini, Said
)
Mitochondrial metabolism in astrocytes - impact on hippocampal neurogenesis and gliogenesis
(Applicant
Beckervordersandforth, Ruth
)
Neuromuscular endplate pathology in autosomal dominant and recessive desminopathies
(Applicants
Hashemolhosseini, Said
;
Schröder, Rolf
)
Regulatory interaction between cellular cyclins and the cyclin-dependent protein kinase ortholog pUL97 of human cytomegalovirus
(Applicants
Marschall, Manfred
;
Sticht, Heinrich
)
The neuromuscular role of canonical Wnt and/or YAP/Taz/Tead signaling
(Applicant
Hashemolhosseini, Said
)
Untersuchung der NFkB Aktivierung in hepatischen Sternzellen. Auswirkungen einer gentherapeutischen NFkB-Blockade auf die Aktivierung dieser Zellen
(Applicant
Hellerbrand, Claus
)
Untersuchung der Rolle von Fibroblast Growth Faktoren (FGF) sowie Sprouties und Spreds als Inhibitoren der FGF-undizierten Signaltransduktion für die hepatische Fibrose
(Applicant
Hellerbrand, Claus
)
Zusammenhang von Genlokalisierung, Rekombinationshäufigkeit und Polymorphismusrate am Beispiel der regulatorischen UE der Proteinphosphatase PPP2R3 und PPP2R3L
(Applicant
Schiebel, Katrin
)
Priority Programmes
Completed projects
Application of Methods from Information Theory in Protein Interaction Analysis
(Applicants
Burkovski, Ph.D., Andreas
;
Huber, Johannes
;
Sticht, Heinrich
)
Einrichtung einer Internet-Datenbank "Molekulare Physiologie der Synapse"
(Applicant
Becker, Cord-Michael
)
Functional heterogeneity and dynamic of astrocytes in the adult mouse hippocampus
(Applicant
Beckervordersandforth, Ruth
)
Glycinrezeptor-Mutanten der Maus: Identifikation von Modulatorgenen
(Applicant
Becker, Cord-Michael
)
SPP 1026: Molekulare Physiologie der synaptischen Interaktion: Analyse in definierten Säugetiermutanten
(Spokesperson
Becker, Cord-Michael
)
Clinical Research Units
Current projects
KFO 5024: Immune checkpoints of gut to brain communication in inflammatory and neurodegenerative diseases (GB.Com)
(Spokesperson
Winner, Beate
)
Role of enteric nervous system homeostasis in gut-nervous system immune signaling
(Applicants
Becker, Christoph
;
Lie, Dieter Chichung
)
Completed projects
Regulation and role of GLUT1 in hepatocellular carcinoma with focus on the interaction between tumor and activated hepatic stellate cells
(Applicant
Hellerbrand, Claus
)
WBP Position
Completed projects
From Sox9 to astrocytes - Intrinsic and extrinsic influences that regulate the “neuron/glial switch” in adult neural stem cells of the hippocampus
(Applicant
Beyer, Felix
)
Collaborative Research Centres
Current projects
The role of mechanics in orchestrating neural lineage decisions
(Project Heads
Falk, Sven
;
Karow, Marisa
)
Completed projects
Bioinformatische Charakterisierung von Protein-Nukleinsäure Wechselwirkungen bei der Transkriptionskontrolle
(Project Head
Sticht, Heinrich
)
Computational analysis of linear interaction motifs and globular protein intervaces in effector proteins
(Project Head
Sticht, Heinrich
)
Funktion und Regulation des Determinationsfaktors GCM in der Säugerentwicklung
(Project Head
Hashemolhosseini, Said
)
Gentherapeutische Ansätze bei akuter und chronischer intestinaler Entzündung in einem induzierten und spontanen Kolitis Tiermodell
(Project Heads
Fleck, Martin
;
Hellerbrand, Claus
;
Herfarth, Ph.D., Hans
)
Membran- und Redoxprozesse bei retinaler Degeneration
(Project Head
Becker, Cord-Michael
)
Modulation des inhibitorischen Glycinrezeptors durch Analgetika und Anästhetika - Charakterisierung nativer und pathologischer Allelvarianten
(Project Heads
Becker, Cord-Michael
;
Becker, Ph.D., Kristina
;
Breitinger, Hans-Georg
)
Strukturelle Aspekte der T-Zell Transformation durch Herpesvirus saimiri
(Project Head
Sticht, Heinrich
)
Strukturmodelle der Komplexe viraler Proteine mit Nukleinsäuren und Wirtsfaktoren
(Project Head
Sticht, Heinrich
)
Research Units
Completed projects
FOR 2127: Selection and Adaptation during Metastatic Cancer Progression
(Spokesperson
Klein, Christoph
)
Role of hepatic stellate cells in the selection and adaptation of metastasizing cancer cells in the hepatic environment
(Applicants
Hellerbrand, Claus
;
Lang, Sven Arke
)
Independent Junior Research Groups
Current projects
Generation of neuronal diversity by temporal mechanisms in the developing spinal cord
(Applicant
Sagner, Andreas
)
CRC/Transregios
Current projects
Steatosis associated soiI factors of the liver metastatic niche
(Project Head
Hellerbrand, Claus
)
Research Training Groups
Current projects
GRK 2162: Neurodevelopment and Vulnerability of the Central Nervous System
(Spokesperson
Lie, Dieter Chichung
)
GRK 2504: Novel antiviral approaches: from small molecules to immune intervention
(Spokesperson
Überla, Klaus
)
GRK 2950: Synthetic Molecular Communication Across Different Scales: From Theory to Experiments
(Spokesperson
Schober, Robert
)
Completed projects
GRK 805: Protein-Protein Interactions in Signal Transduction
(Spokesperson
Hillen, Wolfgang
)
GRK 1071: Viruses of the Immune System
(Spokesperson
Fleckenstein, Bernhard
)
GRK 1910: Medicinal Chemistry of Selective GPCR Ligands
(Spokesperson
Gmeiner, Peter
)
Additional Information
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