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Albert-Ludwigs-Universität Freiburg
Medizinische Fakultät
Institut für Biochemie und Molekularbiologie

Address Stefan-Meier-Straße 17
79104 Freiburg
Deutschland

GERiT This institution in GERiT

79104 Freiburg

Projects

Research Grants
- Current projects
  - Structural and functional studies of import and intermembrane space transfer of mitochondrial membrane proteins
    (Applicant Wiedemann, Nils )
- Completed projects
Research Units
- Current projects
  - Crosstalk and Metabolic Control of Mitochondrial Inner Membrane-Shaping Protein Machineries
    (Applicants van der Laan, Martin ; Rampelt, Heike )
  - FOR 2848: Nanoscale Architecture and Heterogeneity of the Mitochondrial Inner Membrane
    (Spokesperson Jakobs, Stefan )
- Completed projects
Priority Programmes
- Current projects
  - Small membrane proteins as organizers of the bacterial membrane
    (Applicant Koch, Hans-Georg )
Reinhart Koselleck Projects
- Current projects
  - Role of multifunctional proteins in biogenesis, metabolism and regulation of the mitochondrial outer membrane
    (Applicant Pfanner, Nikolaus )
Collaborative Research Centres
- Current projects
  - Adaptive remodeling of ribosome composition and function in response to metabolic changes and cellular stress
    (Project Head Koch, Hans-Georg )
  - Assembly and biogenesis of respiratory complex III and of related supercomplexes
    (Project Head Hunte, Carola )
  - Avidity-driven assembly and properties of cargo in selective autophagy
    (Project Heads Kraft, Claudine ; Wilfling, Florian )
  - Central Coordination of the Collaborative Research Center
    (Project Head Meisinger, Chris )
  - Imaging dynamics of protein machineries and correlation with cellular topologies
    (Project Heads Hugel, Thorsten ; Kraft, Claudine ; Ott, Thomas )
  - Interplay of the Hsp70 Ssb with ribosomes and cochaperones in the cytosol and at the ER membrane
    (Project Head Rospert, Sabine Karola )
  - Modular assembly of the autophagy machinery in mitophagy and immunity
    (Project Heads Gámez-Díaz, Laura ; Kraft, Claudine )
  - Modular organisation of the machinery for membrane insertion of mitochondrial beta-barrel proteins
    (Project Head Wiedemann, Nils )
  - Regulation of biogenesis and function of the mitochondrial protein import machinery by phosphorylation
    (Project Heads Köhn, Maja ; Meisinger, Chris )
  - SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
    (Spokesperson Meisinger, Chris )
  - Structure, function and regulation of disease-relevant renal transport proteins
    (Project Head Hunte, Carola )
- Completed projects
  - Charakterisierung des krebsrelevanten Zuotinhomologs MPP11
    (Project Head Rospert, Sabine Karola )
  - Die Dynamik integraler Translokon- und Assemblierungskomplexe bei der biogenese von bakteriellen Membranproteinen
    (Project Head Koch, Hans-Georg )
  - Die Präsequenz-Translokase der mitochondrialen Innenmembran
    (Project Heads Rehling, Peter ; Truscott, Kaye N. )
  - Einfluss ribosomen-assoziierter Chaperone auf neusynthetisierte Polypeptide in Saccharomyces cerevisiae
    (Project Head Rospert, Sabine Karola )
  - Function of the Hsp70 homolog Ssb in the maintenance of cellular energy homeostasis
    (Project Head Rospert, Sabine Karola )
  - Import und Assemblierung mitochondrialer Außenmembranproteine
    (Project Heads Meisinger, Chris ; Pfanner, Nikolaus )
  - Modulation of sodium/proton exchanger activity by covalent modification and protein interaction
    (Project Head Hunte, Carola )
  - Molekulare Analyse der Wirkung der Immunsuppressiva Cyclosporin A, FK 506 und Rapamycin in T-Lymphozyten
    (Project Head Tropschug, Maximilian )
  - Organization of mitochondrial DNA-protein complexes and mitochondrial cytopathy of the kidney
    (Project Head Wiedemann, Nils )
  - Präprotein-Translokasen der mitochondrialen Innenmembran und des Intermembranraums
    (Project Heads Pfanner, Nikolaus ; Rehling, Peter )
  - Proteinexport und Membranbiogenese gramnegativer Bakterien
    (Project Head Müller, Matthias )
  - Reaction chains directing import and assembly of mitochondrial intermembrane space proteins
    (Project Heads Chacinska, Agnieszka ; Pfanner, Nikolaus )
  - Role of membrane contact sites in preprotein translocation into mitochondria
    (Project Head Pfanner, Nikolaus )
  - Rolle von mitochondrialen Hsp70 und Partnerproteinen beim Proteinimport
    (Project Heads Meisinger, Chris ; Voos, Wolfgang )
  - Sekretariat/Reisekosten/Gastwissenschaftler
    (Project Head Pfanner, Nikolaus )
  - SFB 388: Cellular functions of dynamic protein interactions
    (Spokesperson Pfanner, Nikolaus )
  - Signal sequence-dependent assembly of Tat translocon subunits
    (Project Head Müller, Matthias )
  - Structure and mechanism of the cytochrome bc1 compley and of related supercomplexes
    (Project Head Hunte, Carola )
  - Substratinteraktionen mit den Proteinexport-Translokasen von Escherichia coli
    (Project Head Müller, Matthias )
  - The protein sorting and assembly maschineries of the mitochondrial outer membrane
    (Project Heads Becker, Thomas ; Pfanner, Nikolaus )
  - Zelluläre Funktionen von Peptidyl-prolyl cis/trans Isomerasen
    (Project Head Tropschug, Maximilian )
Research Fellowships
- Completed projects
  - Novel technology for rapid construction of peptide binding molecules with predictable specificity
    (Applicant Tremmel, Dirk )
Major Research Instrumentation
- Completed projects
  - Dekonvolutions-Mikroskop zur 4-dimensionalen Lebendzellmikroskopie
  - TIRF Super-resolution microscope
Research Training Groups
- Current projects
  - GRK 2202: Transport across and into membranes
    (Spokesperson Friedrich, Thorsten )
  - GRK 2606: Understanding protease functions in cellular pathways through discovery and analysis of protease substrates (ProtPath)
    (Spokesperson Reinheckel, Thomas )
- Completed projects
  - GRK 434: Biochemistry of Enzymes
    (Spokesperson Fuchs, Georg )
  - GRK 1976: Functional Diversity of Cofactors in Enzymes
    (Spokesperson Bechthold, Andreas )
International Research Training Groups
- Completed projects
  - GRK 1478: Membrane Proteins and Biological Membranes
    (Spokesperson Friedrich, Thorsten )
Graduate Schools
- Completed projects
  - GSC 4: Molecular Cell Research in Biology and Medicine (MOBILMED)
    (Spokesperson Borner, Christoph )
Clusters of Excellence
- Completed projects
  - EXC 294: Centre for Biological Signalling Studies (bioss) - From Analysis to Synthesis
    (Spokesperson Reth, Michael )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2189: CIBSS - Centre for Integrative Biological Signalling Studies
    (Spokespersons Driever, Wolfgang ; Hunte, Carola ; Kleine-Vehn, Jürgen ; Weber, Wilfried )

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