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Justus-Liebig-Universität Gießen
Fachbereich Medizin
Biochemisches Institut

Address Friedrichstraße 24
35392 Gießen
Deutschland

GERiT This institution in GERiT

35392 Gießen

Projects

Research Grants
- Completed projects
Priority Programmes
- Completed projects
  - Characterisation and sub-cellular localisation of enzyme of the DOXP pathway in Plasmodium falciparum
    (Applicant Beck, Ewald )
  - Characterisation and sub-cellular localisation of enzymes of the DOXP pathway inPlasmodium falciparum
    (Applicant Wiesner, Jochen )
Independent Junior Research Groups
- Completed projects
  - The RBP (Notch) corepressor complex in hematopoiesis
    (Applicant Borggrefe, Tilman )
Research Units
- Current projects
  - FOR 2497: Pemphigus - from Pathogenesis to Therapeutics (Pegasus)
    (Spokesperson Hertl, Michael )
- Completed projects
  - Flotillins in the regulation of desmosomal adhesion in pemphigus
    (Applicant Tikkanen, Ritva )
Collaborative Research Centres
- Current projects
  - Control of Hepatitis C Virus replication by viral and cellular factors
    (Project Head Niepmann, Michael )
  - Disturbed proteoglycan homeostasis drives pulmonary hypertension in lung fibrosis
    (Project Heads Kwapiszewska, Ph.D., Grazyna ; Wygrecka, Malgorzata )
  - Spatio-temporal changes in protein and genetic networks – functional relevance in right heart failure
    (Project Heads Kracht, Michael ; Rohrbach, Susanne ; Schmitz, M. Lienhard )
- Completed projects
  - Die Funktion des Alzheimer-Amyloid-Precursor-Proteins (APP): Identifikation von sAPP-Bindungsstellen, ihr Vorkommen in Mikrodomänen und ihre Endocytose
    (Project Heads Elfgang, Claudia ; Herzog, Volker ; Tikkanen, Ritva )
  - Elucidating the contribution of SIAH2 to the development of cor pulmonale
    (Project Heads Rohrbach, Susanne ; Schmitz, M. Lienhard )
  - Functional characterization of the reggie protein family: posttranslational modifications and signaling partners
    (Project Head Tikkanen, Ritva )
  - Function of Reggie Proteins in Cell Adhesion and Membrane Receptor Trafficking
    (Project Head Tikkanen, Ritva )
  - Mechanismen der Hypoxie-induzierten Proliferation von pulmonalarteriellen Fibroblasten
    (Project Head Schmitz, M. Lienhard )
  - Molekulare Mimikry bei Trematoden
    (Project Head Geyer, Rudolf )
  - Notch signalling in hematopoiesis: The role of RBP-Jk-assosiated transcriptional cofactors in lymphopoiesis
    (Project Head Borggrefe, Tilman )
  - Regulation der Genexpression von Picornaviren und Hepatitis C Virus
    (Project Head Niepmann, Michael )
  - Strukturanalyse von Biomolekülen
    (Project Heads Geyer, Rudolf ; Lochnit, Günter )
  - Struktur- Biosynthese und Funktion von Glykokonjugaten aus Helminthen
    (Project Heads Geyer, Rudolf ; Lochnit, Günter )
  - Struktur, Genese und Funktion der Mikrofilarienscheide
    (Project Heads Beck, Ewald ; Zahner, Horst )
  - The impact of influenza virus genome variability on host cell kinase networks and the anti-viral response
    (Project Heads Pleschka, Stephan ; Schmitz, M. Lienhard )
Clinical Research Units
- Completed projects
  - Membrane Rafts bei der Aktivierung von Makrophagen und bei der epithelialen Regeneration
    (Applicant Tikkanen, Ritva )
Research Fellowships
- Completed projects
  - Untersuchungen des Typ III-Sekretionssystems humanpathogener Yersinia enterocolitica
    (Applicant Schracke, Nadine )
CRC/Transregios
- Completed projects
  - Chromatin regulation mediated by the RBP-J/SHARP corepressor complex
    (Project Head Borggrefe, Tilman )
  - Functional characterization of novel histone phosphorylations
    (Project Head Schmitz, M. Lienhard )
  - FXII – between hypercoagulation and fibrinolysis shutdown in COVID-19
    (Project Heads Hackstein, Holger ; Kübler, Wolfgang ; Preissner, Klaus T. ; Wygrecka, Malgorzata )
  - Host extracellular nucleic acids as DAMPs in severe pneumococcal pneumonia: Pathogenetic mechanisms and therapeutic approaches in combination with adrenomedullin
    (Project Heads Fischer, Silvia ; Müller-Redetzky, Holger )
  - Integrated Research Training Group "Epigenetics and Chromatin"
    (Project Heads Borggrefe, Tilman ; Philipsen, Sjaak ; Suske, Guntram )
Major Research Instrumentation
- Completed projects
  - High-end mass spectrometer with nano-HPLC system
International Research Training Groups
- Completed projects
  - GRK 1062: Signalling Mechanisms in Lung Physiology and Disease (SMLPD)
    (Spokesperson Seeger, Werner )
  - GRK 1384: Enzymes and Multienzyme Complexes Acting on Nucleic Acids
    (Spokesperson Friedhoff, Peter )
  - GRK 1566: Protecting the Heart from Ischemia (PROMISE)
    (Spokesperson Preissner, Klaus T. )
Research Training Groups
- Current projects
  - GRK 2355: Regulatory networks in the mRNA life cycle: from coding to noncoding RNAs
    (Spokesperson Sträßer, Katja )
  - GRK 2573: The inflammatory tumor secretome – from understanding to novel therapies
    (Spokesperson Pogge von Strandmann, Elke )
- Completed projects
  - GRK 370: Biochemistry of Nucloeprotein Complexes
    (Spokesperson Pingoud, Alfred )
Clusters of Excellence
- Completed projects
  - EXC 147: Cardio-Pulmonary System
    (Spokespersons Dimmeler, Stefanie ; Seeger, Werner ; Zeiher, Andreas Michael )
Clusters of Excellence (ExStra)
- Current projects
  - EXC 2026: Cardio-Pulmonary Institute (CPI)
    (Spokespersons Dimmeler, Stefanie ; Seeger, Werner )

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