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Institution
Johannes Gutenberg-Universität Mainz
FB 09: Chemie, Pharmazie, Geographie und Geowissenschaften
Institut für Pharmazeutische und Biomedizinische Wissenschaften
Address
Staudingerweg 5
55128 Mainz
Deutschland
GERiT
This institution in GERiT
55128 Mainz
Projects
Research Grants
Current projects
Deciphering the role of 2’-O-methylated nucleosides in transposon control and neuronal function
(Applicant
Roignant, Jean-Yves
)
Completed projects
3D-Structures and Reaction Mechanisms of Rauvolfia Enzymes
(Applicant
Warzecha, Heribert
)
Bedeutung der oxidativen DNA-Schädigung für die Kanzerogenese
(Applicant
Epe, Bernd
)
Cooperation between epitranscriptomics and the piRNA pathway in maternal mRNA regulation
(Applicant
Roignant, Jean-Yves
)
Deciphering the molecular role of Spenito, a novel component of the m6A methyltransferase complex
(Applicant
Roignant, Jean-Yves
)
Design of novel sensitizers and investigation of tumor targeting carrier systems for their applications in photodynamic therapy
(Applicant
Epe, Bernd
)
Development of non-peptidic cysteine protease inhibitors: etacrynic acid as lead structure
(Applicant
Schirmeister, Tanja
)
Die Biosynthese der pflanzlichen Cellulose
(Applicant
Stöckigt, Joachim
)
Effekte einer genetischen oder pharmakologischen Modulation des P-Glykoprotein auf die Pharmakokinetik und Pharmakodynamik von Neuroleptika
(Applicant
Langguth, Peter
)
Einfluss von oxidativem Stress auf die DNA-Reparatur
(Applicant
Epe, Bernd
)
Elucidating selectivity determining features of proteins with conserved binding sites
(Applicant
Schirmeister, Tanja
)
Entwicklung nichtpeptidischer und peptidomimetischer Cystein-Protease-Inhibitoren mit elektrophilen Bausteinen
(Applicant
Schirmeister, Tanja
)
Entwicklung von Inhibitoren der coronaviralen Hauptprotease als neue antivirale Wirkstoffe gegen SARS (Schweres Aktues Atemwegssyndrom) und andere Coronavirusinfektionen
(Applicants
Baumann, Knut
;
Engels, Bernd
;
Schirmeister, Tanja
;
Schmuck, Carsten
)
Genes of Ajmaline-Synthesis
(Applicant
Stöckigt, Joachim
)
Influence of modulators of chromatin structure and dynamics on the generation and repair of oxidative DNA damage
(Applicant
Epe, Bernd
)
Interaktion zwischen Flavonoiden und Arzneistoffen
(Applicant
Langguth, Peter
)
Oxofunktionalisierte Carbazole/Carbazolalkaloide als potentielle Sauerstoff-Radikalfänger: Synthese und Studium der Eigenschaften
(Applicant
Pindur, Ulf
)
Synthese, 11C-Markierung, 18F-Markierung und Evalulierung Hydantoin-substituierter Indolcarbonsäuren zur Visualisierung des NMDA-Rezeptorstatus in vivo mittels der Positronen-Emissions-Tomographie
(Applicants
Dannhardt, Gerd
;
Rösch, Frank
)
Synthese von hochaffinen 18F-markierten Liganden zur Untersuchung von NMDA-Rezeptoren mittels der Positronen-Emissions-Tomographie (PET)
(Applicant
Rösch, Frank
)
Untersuchungen zur Bioverfügbarkeit und zum intestinalen Transport von Quercetin und Quercetinglykosiden
(Applicant
Langguth, Peter
)
Research Units
Completed projects
Bedeutung der oxidativen DNA-Schädigung für die Tumorentstehung
(Applicant
Epe, Bernd
)
Priority Programmes
Completed projects
Correlation of electron density derived molecular properties with biological activity - a new tool in rational ligand design
(Applicant
Schirmeister, Tanja
)
Mechanistic and functional characterization of Makorin 1 mRNPs
(Applicants
König, Ph.D., Julian
;
Roignant, Jean-Yves
;
Zarnack, Katharina
)
Molecular mechanisms of m6A mRNA modification in Drosophila neurogenesis
(Applicants
Dieterich, Christoph
;
Roignant, Jean-Yves
)
Research Fellowships
Completed projects
Development of subtype-selective GABA mimetics - investigation of their binding mode as well as of signal transduction
(Applicant
Jansen, Michaela
)
Inhibition der Selektin-vermittelten Leukozytenadhäsion als Mechanismus der Wirkung von nichtsteroidalen Antirheumatika (NSAR)
(Applicant
Ulbrich, Holger
)
Structural dynamics of the human telomerase ribonucleoprotein complex
(Applicant
Hengesbach, Martin
)
Collaborative Research Centres
Current projects
Nano-particular mRNA-carrier systems to reprogram different immune-cell populations
(Project Heads
Barz, Matthias
;
Langguth, Peter
;
Sahin, Ugur
)
Targeting and immunomodulator structures and their coupling to therapeutic nanosystems for onco-logical application
(Project Heads
Opatz, Till
;
Schirmeister, Tanja
;
Weil, Tanja
)
Tumor-specific immunization by transcutaneous vaccination: Preclinical and clinical development of drug forms for adjuvant therapy of Merkel cell carcinoma
(Project Heads
Grabbe, Stephan
;
Langguth, Peter
;
Radsak, Markus P.
)
Completed projects
Bedeutung der gentoxischen Wirkungen reaktiver Sauerstoffspezies für die Tumorentstehung
(Project Head
Epe, Bernd
)
Proteases as targets for agents against infectious diseases
(Project Head
Schirmeister, Tanja
)
Proteases as targets for new antiinfective agents
(Project Head
Schirmeister, Tanja
)
Structural dynamics of eukaryotic H/ACA complexes
(Project Head
Hengesbach, Martin
)
DIP Programme
Completed projects
The epitranscriptome (m6A, m1A and Nm) in regulation of RNA fate
(Applicants
Rechavi, Gideon
;
Roignant, Jean-Yves
)
Major Research Instrumentation
Completed projects
Vollautomatisiertes isothermales Titrationskalorimeter (ITC)
CRC/Transregios
Current projects
Assembly, activity, and structural dynamics in eukaryotic H/ACA complexes
(Project Head
Hengesbach, Martin
)
Functional roles of 5-methylcytosine (m5C) in regulating cell fate in normal tissues and human disease
(Project Heads
Frye, Ph.D., Michaela
;
Lyko, Frank
;
Schirmeister, Tanja
)
The mechanistic and functional impact of RNA modifications on alternative splicing
(Project Heads
Dieterich, Christoph
;
König, Ph.D., Julian
;
Roignant, Jean-Yves
)
Independent Junior Research Groups
Completed projects
Cations in charge of RNA folding and function: Realistic modeling and robust predictions
(Applicant
Schwierz, Ph.D., Nadine
)
Research Training Groups
Completed projects
GRK 1910: Medicinal Chemistry of Selective GPCR Ligands
(Spokesperson
Gmeiner, Peter
)
GRK 2015: Life Sciences, Life Writing: Boundary Experiences of Human Life between Biomedical Explanation and Lived Experience
(Spokesperson
Paul, Norbert W.
)
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