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Institution
Johannes Gutenberg-Universität Mainz
Universitätsmedizin
Institut für Immunologie
Address
Langenbeckstraße 1
55131 Mainz
Deutschland
GERiT
This institution in GERiT
55131 Mainz
Projects
Research Grants
Current projects
Modifying macrophage polarization to improve cancer immunotherapies
(Applicants
Alflen, Astrid
;
Bohn, Toszka
)
Role of T-cell derived prothrombin in septicemia
(Applicants
Danckwardt, Sven
;
Probst, Hans Christian
)
Completed projects
Alternative splicing as an element of signal transduction in multi-step phosphorelay systems of fungi
(Applicants
Jacob, Stefan
;
Tenzer, Stefan
)
Analysis of the mechanisms involved in functional impairment of cytotoxic T cells during chronic viral infection
(Applicant
Probst, Hans Christian
)
Comparative studies on the regulation of the production of the asthma-inducing cytokin Interleukin 9 (IL-9) in primary murine mast cells and T-cells
(Applicant
Schmitt, Edgar
)
Deciphering the role of the IRF4 interactome in differentiating regulatory T and T helper 17 cells in health and autoimmune disease
(Applicants
Bopp, Tobias
;
Distler, Ute
)
Die kutane Mastzelle als potenter Initiator entzündlicher Reaktionen
(Applicant
Stassen, Michael
)
Effect of tick saliva cystatins on Th9 cells, mast cells and the development of experimental asthma
(Applicant
Schmitt, Edgar
)
Identification and characterization of L. major T cell epitopes based on quantitative proteomics
(Applicants
von Stebut-Borschitz, Ruth Esther
;
Tenzer, Stefan
)
Polyphosphates as Novel Pathogen-Associated Molecular Patterns in Macrophages
(Applicant
Bosmann, Markus
)
The role of TREM-1 and it´s ligand in regulating the innate immune response
(Applicant
Radsak, Markus P.
)
Transcriptional Regulation in Murine Regulatory T Cells and Suppressed CD4+ T Cells: Identification and Functional Analyses
(Applicants
Bopp, Tobias
;
Schmitt, Edgar
)
Wheat sensitivity: Impact of wheat varieties and wheat growing conditions on innate immunity
(Applicants
Longin, Friedrich
;
Schuppan, Detlef
;
Tenzer, Stefan
)
Priority Programmes
Completed projects
Activation mechanisms by TREM-1 and it´s significance in immunomodulation post trauma
(Applicant
Radsak, Markus P.
)
Functional characterization of cell-specific differences of L. major-containing phagolysosomes in macrophages and dendritic cells
(Applicants
von Stebut-Borschitz, Ruth Esther
;
Tenzer, Stefan
)
Integrated Proteomics and Lipidomics Platform
(Applicants
Bindila, Ph.D., Laura
;
Distler, Ute
)
Interactions between mast cells and neutrophils in murine models of acute inflammation
(Applicant
Stassen, Michael
)
Mast cells as inducers and modulators of adaptive immune responses
(Applicant
Stassen, Michael
)
Rapid adaptation of signaling networks in the fungal Pathogen Magnaporthe oryzae
(Applicants
Jacob, Stefan
;
Tenzer, Stefan
)
Spezifität und Mechanismus des eukaryotischen 20S/26S Proteasoms (Specificity and mechanism of the eukaryotic 20S/26S proteasome)
(Applicant
Schild, Hansjörg
)
Thiol switches controlled by the glutathione-S-transferase GDAP1
(Applicants
Methner, Axel
;
Tenzer, Stefan
)
Collaborative Research Centres
Current projects
Central Task
(Project Head
Schild, Hansjörg
)
Development and testing of nanoparticles to eliminate the cAMP-mediated immune-suppression in the malignant melanoma
(Project Heads
Barz, Matthias
;
Becker, Christian
;
Bopp, Tobias
)
Evaluation of systemic mRNA/peptide-based nanoparticle vaccines in melanoma tumor models
(Project Heads
Diken, Mustafa
;
Schild, Hansjörg
)
From nanomaterial surface to function - multifunctional PEGylation, targeting and in vivo proteomics
(Project Heads
Frey, Holger
;
Mailänder, Volker
;
Tenzer, Stefan
)
Integrated OMICS, Bioinformatics and Morpho-molecular Immunomonitoring Unit
(Project Heads
Albrecht, Christian
;
Bukur, Valesca
;
Gaida, Matthias
;
Tenzer, Stefan
)
Integrated Research Training Group
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
Microbiota induced tonic type I interferons in the control of CTL responses to cancer, chronic and acute virus infections
(Project Heads
Probst, Hans Christian
;
Schild, Hansjörg
)
Multifunctional nanosized peptide/glycopeptide conjugates as fully-synthetic vaccine for tumor-immunotherapy
(Project Heads
Besenius, Pol
;
Bopp, Tobias
;
Schmitt, Edgar
)
Nano-particular mRNA-carrier systems to reprogram different immune-cell populations
(Project Heads
Barz, Matthias
;
Langguth, Peter
;
Sahin, Ugur
)
Neo-epitope specific CD4+ T cells – Anti-tumoral mechanisms and their modulation
(Project Heads
Kreiter, Sebastian
;
Sahin, Ugur
)
Polymer-mediated tumor immunotherapy via in situ activation of antigen-presenting cells
(Project Heads
Grabbe, Stephan
;
Nuhn, Lutz
;
Schild, Hansjörg
)
Regulation and host targets of viral immune evasion
(Project Heads
Distler, Ute
;
Lemmermann, Niels
;
Reddehase, Matthias J.
)
Removal of the acidosis-dependent immune evasion mechanism of the malignant melanoma using pH modulating nanocarrier
(Project Heads
Bohn, Toszka
;
Miederer, Ph.D., Matthias
;
Weil, Tanja
)
SFB 1292: Targeting convergent mechanisms of inefficient immunity in tumors and chronic infections
(Spokesperson
Schild, Hansjörg
)
T cell recognition and immune editing in SCLC
(Project Heads
Kolb, Ph.D., Laura
;
Sahin, Ugur
)
Understanding the role of GPCR65-dependent metabolic communication in the tumor microenvironment
(Project Heads
Bopp, Tobias
;
Schmitt, Edgar
)
Completed projects
Entwicklung RNS basierter Impfstoffe zur Induktion integrierter T und B-Zellimmunantworten gegen molekular definierte Tumorantigene
(Project Head
Sahin, Ugur
)
Isolierung und Charakterisierung muriner CD25+ T-regulatorischer Zellen und funktionelle Analyse ihrer suppressiven Wirkung auf konventionelle T-Zellen und Th2-Zellen
(Project Head
Schmitt, Edgar
)
Massenspektrometrie
(Project Head
Tenzer, Stefan
)
Molecular interactions during MHC class I-restricted antigen processing
(Project Heads
Schild, Hansjörg
;
Tenzer, Stefan
)
Molekulare Interaktionen bei der MHC-Klasse-I-restringierten Antigenprozessierung
(Project Head
Schild, Hansjörg
)
Molekulare Interaktionen bei der MHC-Klasse-I-restringierten Antigenprozessierung
(Project Head
Schild, Hansjörg
)
Phagozytose-induzierte Antigenprozessierung in prädifferenzierten dendritischen Zellen aus Zytokin-gesteuerten Knochenmarkkulturen
(Project Head
Reske, Konrad
)
Proteins on nanocarriers: from the stealth effect to active targeting in vivo
(Project Heads
Mailänder, Volker
;
Tenzer, Stefan
;
Weil, Tanja
)
Regulation der Adhäsion von Tumorzellen durch extra- und intrazelluläre Liganden von E-Selektin
(Project Heads
Dippold, Wolfgang
;
Schmitt, Edgar
)
Selektion und Transfer therapeutischer T-Zellrezeptoren
(Project Heads
Schild, Hansjörg
;
Theobald, Matthias
;
Voss, Ralf-Holger
)
Spezifische Aspekte der Cytokinproduktion von Mastzellen und die Bedeutung von Mastzellen und ihren Produkten während der Sensibilisierung und Manifestation des atopischen Asthma
(Project Head
Stassen, Michael
)
Targeted inflammation - improving migration of leucocytes to the tumor through polymer-assisted activating of tumor endothelial tissue
(Project Heads
Sahin, Ugur
;
Schmitt, Edgar
)
Tumorabstoßung durch zytotoxische T-Zellen in vivo: Einfluß von Toll-like Rezeptor vermittelten Signalen
(Project Heads
Radsak, Markus P.
;
Schild, Hansjörg
)
Umfassende Analyse molekular und immunologisch definierter Alterationen beim Bronchialkarzinom
(Project Head
Sahin, Ugur
)
Clinical Research Units
Completed projects
Modulation von Graft-versus-Host und Graft-versus-Tumor Reaktionen durch regulatorische T-Zellen
(Applicant
Radsak, Markus P.
)
CRC/Transregios
Current projects
CK2 as a Molecular Switch Regulating Immunity and Tolerance by APC-dependent Induction of Treg cells
(Project Heads
Bopp, Tobias
;
Clausen, Björn
)
Control of cytotoxic T cell responses in the skin by mononuclear phagocytes during primary viral infection and memory recall
(Project Heads
Probst, Hans Christian
;
Schild, Hansjörg
)
In situ reprogramming of dendritic cells for immunomodulation of CNS-specific Foxp3+ regulatory T cells
(Project Heads
Sahin, Ugur
;
Waisman, Ari
)
Myeloid cell–regulatory T cell crosstalk in thrombus development and resolution
(Project Heads
Bopp, Tobias
;
Ruf, Wolfram
)
The role of CD18 and regulatory T cells in skin inflammation
(Project Heads
Bopp, Tobias
;
Grabbe, Stephan
)
Completed projects
Central Tasks of the Collaborative Research Centre/Secretariat
(Project Head
Schmitt, Edgar
)
Functional Characterization of New Regulatory RUNX1 (AML1) Isoforms in T Cells
(Project Heads
Gattenlöhner, Stefan
;
Schmitt, Edgar
)
Transcription Factors of Murine Regulatory T Cells and Suppressed CD4+ T Cells: Identification and Functional Analyses
(Project Heads
Bopp, Tobias
;
Schmitt, Edgar
)
Transcutaneous immunization: Mechanisms of intercellular crosstalk in the skin
(Project Heads
Radsak, Markus P.
;
Stassen, Michael
)
TRR 52: Transcriptional Programming of Individual T Cell Subsets
(Spokesperson
Schmitt, Edgar
)
Unraveling the role of myeloid cells and metabolism in clinical progression of MS
(Project Heads
Bittner, Stefan
;
Bopp, Tobias
;
Zipp, Frauke
)
Major Research Instrumentation
Completed projects
Hochauflösende Elektrospray-Ionisations Hybrid-Massenspektrometer Plattform
Research Training Groups
Completed projects
GRK 1043: Antigen-specific Immuntherapy
(Spokesperson
Wölfel, Thomas Johann
)
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