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Institution
Universitätsklinikum Ulm
Institut für Molekulare Virologie
Address
Meyerhofstraße 1
89081 Ulm
Deutschland
GERiT
This institution in GERiT
89081 Ulm
Projects
Research Grants
Current projects
De Novo Design of Envelope-Targeting Antiviral Peptide Drugs
(Applicants
Münch, Jan
;
Risselada, Ph.D., Herre Jelger
)
Development of a new class of radiopharmaceuticals for diagnosis and therapy of CXCR4-expressing malignancies based on the endogenous CXCR4 antagonist EPI-X4
(Applicant
Münch, Jan
)
Innate immune determinants of human Coronavirus endemisation
(Applicants
Kmiec, Dorota
;
Sparrer, Konstantin
)
Intracellular trafficking in innate immunity
(Applicant
Sparrer, Konstantin
)
Role of cellular Helicases and Nucleases in HIV-1 infection and lentiviral transduction.
(Applicants
Kirchhoff, Frank
;
Volcic, Meta
)
Completed projects
Antiviral Activity of Guanylate-Binding Proteins and Viral Countermeasures
(Applicant
Kirchhoff, Frank
)
Crossing Barriers with bio-based Therapeutics
(Applicant
Otte, Ph.D., Kerstin
)
Die Funktion(en) des nef-Gens der Immundefizienzviren
(Applicant
Kirchhoff, Frank
)
Endocrine in vitro models to study pathophysiology and diabetes in SARS-CoV-2/COVID-19
(Applicants
Kleger, Alexander
;
Münch, Jan
)
Evolution der nef-Funktion nach der Übertragung der Immundefizienzviren von natürlich infizierten Affen auf den Menschen
(Applicant
Kirchhoff, Frank
)
Fehlregulation von T-Zellfunktionen durch pathogene und apathogene Immundefizienzviren
(Applicant
Kirchhoff, Frank
)
Impact of SARS-CoV-2 on the barrier function of the airway epithelium
(Applicants
Kirchhoff, Frank
;
Wittekindt, Oliver
)
Mechanism and Structural Basis of SEVI-Mediated Enhancement of HIV Infection
(Applicants
Fändrich, Marcus
;
Münch, Jan
)
Role of Nef-mediated TCR-CD3 downmodulation in the pathogenesis of AIDS
(Applicants
Kirchhoff, Frank
;
Stahl-Hennig, Christiane
)
Role of the natural CXCR4 antagonist ALB408-423 in health and disease
(Applicant
Münch, Jan
)
SARS-CoV-2 induced damage of the alveolar epithelium in the lung and its inhibition by α1-antitrypsin.
(Applicants
Frick, Manfred
;
Münch, Jan
)
Targeting CXCR4 to suppress virus-induced activation of plasmacytoid dendritic cells
(Applicants
Münch, Jan
;
Smith, Ph.D., Nikaïa
)
The innate immune antagonism of SARS-CoV-2 ORF3a, ORF6 and ORF7a
(Applicant
Sparrer, Konstantin
)
The role of autophagy during viral infection
(Applicant
Sparrer, Konstantin
)
Type I interferon induction and elimination of memory T cells by HIV and other primate lentiviruses
(Applicant
Kirchhoff, Frank
)
Priority Programmes
Completed projects
Manipulation of ILC function and survival by human and simian immunodeficiency viruses
(Applicant
Kirchhoff, Frank
)
Nanodiamonds as sensitive sensors to study tetherin structure and dynamics
(Applicants
Jelezko, Fedor
;
Kirchhoff, Frank
;
Weil, Tanja
)
Role of PYHIN proteins in retroviral restriction, spread and latency
(Applicant
Kirchhoff, Frank
)
The role of bystander cell autophagy in HIV-1 infection
(Applicant
Sparrer, Konstantin
)
Collaborative Research Centres
Current projects
Amyloid biology of bioinspired peptides - from basic research to preclinical development
(Project Heads
Fändrich, Marcus
;
Münch, Jan
;
Walther, Paul
)
Central tasks of the CRC
(Project Head
Kirchhoff, Frank
)
Characterization and optimization of the CXCR4 antagonist EPI-X4
(Project Heads
Klein, Florian
;
Münch, Jan
;
Sanchez Garcia, Elsa
)
Characterization of novel peptide ligands of GPCRs involved in lentiviral infections
(Project Head
Kirchhoff, Frank
)
Identification and characterization of antimicrobial peptides from major pathogen entry and replication sites
(Project Heads
Münch, Jan
;
Spellerberg, Barbara
)
Interplay between HIV and amyloids in human aging
(Project Head
Kirchhoff, Frank
)
Peptides targeting the fusion peptides of enveloped viral pathogens
(Project Heads
Kirchhoff, Frank
;
Weil, Tanja
)
Regulation of autophagy by human peptides and exploration of their anti-microbial and anti-cancer properties
(Project Head
Sparrer, Konstantin
)
SFB 1279: Exploiting the Human Peptidome for Novel Antimicrobial and Anticancer Agents
(Spokesperson
Kirchhoff, Frank
)
Completed projects
Bedeutung verschiedener Korezeptoren für die Pathogenese und Transmission der Immundefizienzviren
(Project Head
Kirchhoff, Frank
)
Clinical Research Units
Completed projects
Dysregulation von Apoptose durch Immundefizienzviren
(Applicant
Kirchhoff, Frank
)
Major Research Instrumentation
Completed projects
Konfokales Mikroskop
Zellanalysegerät
Zellsortierer
Research Fellowships
Completed projects
Targeting RNA virus replication by ZAP, TRIM25, and their cofactors
(Applicant
Kmiec, Dorota
)
TRIM proteins in autophagy-mediated antiviral defense
(Applicant
Sparrer, Konstantin
)
Research Training Groups
Completed projects
GRK 1789: Cellular and Molecular Mechanisms in Aging (CEMMA)
(Spokesperson
Geiger, Hartmut
)
Graduate Schools
Completed projects
GSC 270: International Graduate School in Molecular Medicine Ulm
(Spokesperson
Kühl, Michael
)
Additional Information
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