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Institution
Universitätsklinikum Jena
Klinik für Anästhesiologie und Intensivmedizin
Address
Am Klinikum 1
07747 Jena
Deutschland
GERiT
This institution in GERiT
07747 Jena
Projects
Priority Programmes
Completed projects
Dual role of plasma secreted sphingomyelinase activity during sepsis and development of organ failure
(Applicant
Claus, Ph.D., Ralf
)
Funktionsanalyse der Wechselwirkungen von Phosphoinositid 3-Kinase gamma (PI3Kgamma) mit Ras und heterotrimeren G-Proteinen
(Applicant
Wetzker, Reinhard
)
Research Grants
Current projects
Investigation of the Protein kinase C alpha signaling in the development of sepsis-associated liver failure.
(Applicant
Press, Adrian
)
Completed projects
Compartmentalized signalling of Ras in cancer cells
(Applicants
Böhmer, Frank-Dietmar
;
Rubio, Ignacio
)
Contribution of the separate complement pathways for outcome and negative effects on innate immune functions during sepsis
(Applicant
Riedemann, Niels Christoph
)
Differential Gene Expression Patterns in Patients with Trauma and Sepsis - TraumArraytor
(Applicant
Reinhart, Konrad
)
Does multimodal pain treatment affect neurotransmitter turnover and functional connectivity in the brain of patients with chronic pain?
(Applicants
Gussew, Alexander
;
Meißner, Winfried
)
Dynamische Balance zwischen Von-Willebrand Faktor und dessen Protease ADAMTS13 bei Inflammation und Hämostase
(Applicant
Claus, Ph.D., Ralf
)
Isotype-specific analysis of Ras-subfamily member signalling using xanthine nucleotide selective mutants
(Applicant
Rubio, Ignacio
)
Komplexität zur Kennzeichnung neurovegetativer Dynamik bei schweren Hirnfunktionsstörungen und Prüfung ihrer diagnostischen Relevanz
(Applicant
Zwiener, Ulrich
)
Kooperation von G Protein-gekoppelten Rezeptoren und Rezeptortyrosinkinasen bei der Regulation der MAP Kinase
(Applicant
Liebmann, Claus
)
Kooperation von G Protein-gekoppelten Rezeptoren und Rezeptortyrosinkinasen bei der Regulation der MAP Kinase
(Applicant
Presek, Peter
)
Multiple functions of PI 3-Kinase-Gamma
(Applicant
Wetzker, Reinhard
)
Quantifizierung intestinaler Mikrozirkulationsstörungen im experimentellen Modell der Sepsis mittels konfokaler Laserendoskopie
(Applicant
Stallmach, Andreas
)
Regional differences in severe sepsis epidemiology and treatment in Germany
(Applicant
Fleischmann-Struzek, Carolin
)
Role of SPRED1 and endocytosis in the regulation of the Ras/Erk pathwayand
(Applicant
Rubio, Ignacio
)
The impact of MAPK inhibition on lung innate immunity and outcome in a new model of acute trauma/hemorrhage and subsequent pneumococcal pneumonia
(Applicants
Maus, Ulrich A.
;
Riedemann, Niels Christoph
)
The mechanism(s) of Ras deactivation in growth factor signalling: role and regulation of the tumor suppressor gene product neurofibromin
(Applicant
Rubio, Ignacio
)
Research Fellowships
Completed projects
Artificial oxygen carriers for supportive therapy in hemorrhagic shock. Influence on regional oxygen supply, hepatocellular redox state, and stress response.
(Applicant
Paxian, Markus
)
New therapeutic strategies for prevention of multiple organ dysfunction associated with shock of various aetiologies
(Applicant
Coldewey, Ph.D., Sina Maren
)
Research Units
Completed projects
Impact of heme and heme degradation products on acute kidney injury associated with Shiga toxin 2-induced hemolytic-uremic syndrome
(Applicant
Coldewey, Ph.D., Sina Maren
)
Collaborative Research Centres
Current projects
Multifunctional nanoparticles based on polysaccharides for targeted drug delivery with two-step release behavior
(Project Heads
Coldewey, Ph.D., Sina Maren
;
Heinze, Thomas
;
Heinzel, Thorsten
)
Targeting renal phosphoinositide 3-kinase γ (PI3Kγ) by dye-tagged nanoparticles
(Project Heads
Bauer, Michael
;
Coldewey, Ph.D., Sina Maren
;
Schubert, Ulrich S.
)
The mechanism and the immunomodulatory consequences of protein adsorption on stealth nanoparticles
(Project Heads
Hellmich, Ute
;
Press, Adrian
)
Completed projects
Functional pattern of phosphoinositide 3-kinase y (PI3Ky) in neurons
(Project Head
Wetzker, Reinhard
)
Organisation und allgemeine Aufgaben
(Project Head
Wetzker, Reinhard
)
SFB 604: Multifunctional signaling proteins
(Spokesperson
Wetzker, Reinhard
)
Clinical Trials
Completed projects
A Randomized Controlled Multicenter Trial on Albumin Replacement In Septic Shock (ARISS)
(Applicant
Bauer, Michael
)
Research Training Groups
Completed projects
GRK 768: Biomolecular Switches ? Coding of Proteins via Conformational Changes and Posttranslational Modifications
(Spokesperson
Heinemann, Stefan H.
)
GRK 1402: Human Dignity and Human Rights - Genesis, Development and Application of Central Values of Modernity
(Spokespersons
Joas, Hans
;
Knoepffler, Nikolaus
)
GRK 1715: Molecular Signatures of Adaptive Stress Responses
(Spokespersons
Heinzel, Thorsten
;
Wetzker, Reinhard
)
Additional Information
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