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Institution
Technische Universität Dresden
Medizinische Fakultät Carl Gustav Carus
Institut für Physiologische Chemie
Address
Fetscherstraße 74
01307 Dresden
Deutschland
GERiT
This institution in GERiT
01307 Dresden
Projects
Research Units
Current projects
FOR 2599: Tissue type 2 responses: Mechanisms of induction and regulation
(Spokesperson
Roers, Axel
)
Completed projects
Control of high-affinity IgE responses to animal venoms by skin innate type 2 immunity
(Applicants
Jessberger, Rolf
;
Roers, Axel
)
Das Verhalten von Knochenzellen an biologisch funktionalisierten Verbundwerkstoffen
(Applicant
Hempel, Ute
)
Priority Programmes
Completed projects
Control of Tumor Cell – Bone Metastasis By Regulation of F-Actin Dynamics
(Applicant
Jessberger, Rolf
)
Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss
(Applicants
Hofbauer, Lorenz C.
;
Rauner, Martina
)
Interplay between the Immune System and the Bone in the SWAP-70-/-mouse
(Applicant
Garbe, Annette
)
Koordinationsprojekt
(Applicant
Jessberger, Rolf
)
Optimierung der Osseointegration von Knochenimplantaten durch gradierte supramolekulare Strukturen auf der Basis von Fibronektin und Kollagen der Typen I und III
(Applicant
Hempel, Ute
)
SPP 1384: Mechanisms of Genome Haploidisation
(Spokesperson
Jessberger, Rolf
)
Stem Cells to Germ Cells: Development of Germ Stem Cell Systems to Study Gametogenesis and Meiosis
(Applicant
Jessberger, Rolf
)
The Functions of Cohesins in Mammalia Meiosis
(Applicant
Jessberger, Rolf
)
The molecular basis of HORMAD1 dependent coordination of key meiotic processes
(Applicant
Tóth, Attila
)
The role of SWAP-70 in mast cell adhesion, migration and F-actin cytokeletal rearrangements
(Applicant
Jessberger, Rolf
)
Research Grants
Current projects
Ensuring correct meiotic chromosome behaviour: mechanisms of synaptonemal complex stabilization and extension
(Applicant
Tóth, Attila
)
Molecular pathways of meiotic prophase checkpoints in mice
(Applicant
Tóth, Attila
)
Regulation and cleavage specificity of the ER-resident intramembrane proteases SPPL2c and SPP
(Applicant
Mentrup, Torben
)
Regulation of the DNA-degrading enzyme TREX1 by intramembrane proteolysis and its implications for human auto-immune diseases as well as a model for ER proteostasis
(Applicant
Schröder, Bernd
)
The biogenesis of nucleosome arrays and their decline during cellular aging
(Applicant
Müller-Planitz, Felix
)
Completed projects
A novel mouse model for osteopetrosis
(Applicant
Jessberger, Rolf
)
A novel pathway that controls production of IgE in B cells
(Applicant
Jessberger, Rolf
)
Aufklärung molekularer Mechanismen bei der Wechselwirkung von Osteoblasten mit löslichen und immobilisierten Hyaluronsäurederivaten
(Applicant
Hempel, Ute
)
Completion of DNA break repair and crossover formation in mammalian meiosis; the critical functions of a previously uncharacterised meiotic protein, MES19
(Applicant
Tóth, Attila
)
Conformational dynamics of the ISWI chromatin remodeling enzyme
(Applicant
Müller-Planitz, Felix
)
Control of Dendritic Cell Maturation and Migration by the RhoGTPase Regulators SWAP-70 and DEF6.
(Applicant
Ocaña Morgner, Ph.D., Carlos
)
Einfluss von Tyrosinkinase-Inhibitoren auf das wachsende Skelettsystem
(Applicants
Hofbauer, Lorenz C.
;
Suttorp, Meinolf
)
Function of Cohesin SMC1beta in Mammalian Meiosis
(Applicant
Jessberger, Rolf
)
Functions of a newly identified meiotic protein, SCML1, and a meiosis-specific nuclear structure, the dense-body, in mice
(Applicant
Tóth, Attila
)
Functions of the Tudor-domain containing protein TDRD6 in male germ cells
(Applicant
Jessberger, Rolf
)
How do cells enter meiosis? Identification and characterisation of novel regulators of entry into the meiotic program.
(Applicant
Stevense, Michelle
)
Identification of Novel Regulators of Entry into the Meiotic Program
(Applicant
Stevense, Michelle
)
Physiological role of the intramembrane proteases SPPL2a/b in the homeostasis of tail-anchored proteins
(Applicants
Schröder, Bernd
;
Schwappach-Pignataro, Blanche
)
Principles of the spatiotemporal control of meiotic recombination initiation in mice
(Applicants
Rulands, Steffen
;
Tóth, Attila
)
Roles of Cohesins SMC3, RAD21 and STAG3 in Mammalian Meiosis
(Applicant
Jessberger, Rolf
)
Signaltransduktion und Differenzierung in Lungenepithelzellen nach Schädigung - in vitro Untersuchungen
(Applicant
Koslowski, Roland
)
Spatiotemporal control of DNA double strand break formation in mammalian germ cells by a newly discovered meiosis-specific protein, ANKRD31
(Applicant
Tóth, Attila
)
The functions of a previously uncharacterized meiotic protein, MCMDC2, that is crucial for meiotic recombination and fertility in mouse.
(Applicant
Tóth, Attila
)
The mechanism of ATP-dependent nucleosome remodeling -- Dissection of the function of important protein domains and nucleosomal epitopes
(Applicant
Müller-Planitz, Felix
)
The molecular basis of HORMAD2 functions in meiotic checkpoint control
(Applicant
Tóth, Attila
)
The molecular role of the invariant chain/CD74 and its proteolytic degradation in dendritic cell function and anti-mycobacterial immune recognition
(Applicant
Schröder, Bernd
)
The Role of CENP-V in Mammalian Meiosis
(Applicant
Jessberger, Rolf
)
The role of SWAP-70 in Dendritic Cell Activation, Antigen Presentation and Migration
(Applicant
Jessberger, Rolf
)
The Roles of Cohesin Regulator Proteins in Mammalian Meiosis
(Applicant
Jessberger, Rolf
)
Wechselwirkungen korrosions-induzierter und zellulärer reaktiver Spezies mit Titanprobekörpern und Zellen. Rückschlüsse auf die Vorgänge an der Implantat-Gewebe-Grenzfläche in vivo
(Applicant
Dieter, Peter
)
Heisenberg Fellowships
Completed projects
Zellbiologie
(Applicant
Tóth, Attila
)
Heisenberg Professorships
Completed projects
The molecular basis of maintaining genome integrity in the mammalian germline during meiosis
(Applicant
Tóth, Attila
)
Collaborative Research Centres
Completed projects
Characterization of the in vivo functions of Signal-peptide-peptidase-like 2 intramembrane proteases
(Project Heads
Saftig, Paul
;
Schröder, Bernd
)
Nucleosome spacing in a folded chromatin environment
(Project Head
Müller-Planitz, Felix
)
Regulation of cell adhesion, trafficking, and lymphoid tissue formation by SWAP-70
(Project Head
Jessberger, Rolf
)
Regulation of hematopoietic cell differentiation, adhesion, migration, and lymphoid tissue formation by the SWEF proteins
(Project Head
Jessberger, Rolf
)
CRC/Transregios
Completed projects
Influence of artificial and native extracellular matrices on adhesion and differentiation of mesenchymal stem cells and osteoblasts
(Project Head
Hempel, Ute
)
Influence of multiphase-bone replacement materials and surface-modified titanium alloys on the differentiation of osteoblasts/MSC
(Project Heads
Arnhold, Stefan
;
Hempel, Ute
)
Major Research Instrumentation
Completed projects
Fluorescence Activated Cell Analyzer (FACS)
Graduate Schools
Completed projects
GSC 97: Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB)
(Spokesperson
Rödel, Gerhard
)
Clusters of Excellence
Completed projects
EXC 168: Regenerative Therapies - From Cells to Tissues to Therapies: Engineering the Cellular Basis of Regeneration
(Spokespersons
Bonifacio, Ph.D., Ezio
;
Brand, Michael
;
Calegari, Ph.D., Federico
;
Tanaka, Ph.D., Elly Margaret
)
Additional Information
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