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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für Innere Medizin
I. Medizinische Klinik und Poliklinik
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Composition and functional heterogeneity of naïve-like T cells in primary sclerosing cholangitis (PSC)
(Applicant
Schwinge, Dorothee
)
Consequences of Hepatitis B virus DNA integrations for the host and the virus using a new mouse model
(Applicant
Allweiss, Lena
)
Developmental trajectory and function of Th10 cells in IBD
(Applicants
Gagliani, Ph.D., Nicola
;
Huber, Samuel
)
iDfellows: Hamburg Clinician Scientist Programme in Infectious Diseases
(Applicant
Lohse, Ansgar W.
)
Impact of the apoptotic cell identity on macrophage function: A novel approach for the re-establishment of liver homeostasis upon damage
(Applicant
Bosurgi, Ph.D., Lidia
)
Influence of the microbiota on intestinal dendritic cells and its impact on Inflammatory Bowel Disease
(Applicant
Velasquez, Ph.D., Lis Noelia
)
LAM Cell-based therapy of inflammatory metabolic diseases
(Applicant
Adlung, Lorenz
)
Regulation of immune cell populations and immune pathways by sex hormones
(Applicant
Altfeld, Marcus
)
The CD4+ T cell memory in Plasmodium falciparum malaria
(Applicant
Mackroth, Maria Sophia
)
The role of liquid biopsy in identifying circulating molecular predictors of response or resistance to systemic therapy in hepatocellular carcinoma
(Applicant
von Felden, Johann
)
The role of miR-122 in autoimmune liver diseases
(Applicant
Herkel, Johannes
)
Completed projects
Analysis of the molecular and functional heterogeneity of Foxp3Neg IL-10-producing T cells
(Applicants
Gagliani, Ph.D., Nicola
;
Huber, Samuel
)
Bedeutung des fibrotischen Mikromilieus für die Entstehung des Hepatozellulären Karzinoms
(Applicant
Kluwe, Johannes
)
Charakterisierung der adaptiven Immunantwort gegen das SepSecS Molekül bei autoimmuner Hepatitis
(Applicant
Weiler-Normann, Christina
)
Charakterisierung genetischer Veränderungen im Rahmen der malignen Transformation von Telomerase-immortalisierten humanen Hepatozyten
(Applicant
Wege, Henning
)
Charakterisierung Hämoxygenase-1-basierter Therapieoptionen bei chronischer Hepatitis C Virus Infektion
(Applicant
Sass, Gabriele
)
Charakterisierung Hepatitis C Virus spezifischer CD4+ T Helfer Zell Antworten
(Applicant
Schulze zur Wiesch, Julian
)
Control of pro-inflammatory TH17 cells in the small intestine
(Applicant
Huber, Samuel
)
Die Bedeutung des CCK2-Rezeptors und seines Liganden Gastrin für C-Zellen, Calcitonin-Genexpression und Knochenstoffwechsel
(Applicant
Bläker, Michael
)
Die Rolle von Transforming growth factor-ß1 (TGF-ß1) und Platelet-derived growth factor (PDGF) im Rahmen der Leberfibrogenese: Studie an transgenen Mausmodellen
(Applicant
Lohse, Ansgar W.
)
Functional characterization of Gonadotropin Releasing Hormone Receptor (GnRH-R) in Non Hodgkin´s Lymphoma (NHL) and Urothelial Carcinoma- a novel therapeutic target
(Applicant
von Amsberg, Gunhild
)
Hepatozytenabhängige Mechanismen des T-Zellversagens bei chronischer Virushepatitis
(Applicant
Wiegard, Christiane
)
Human Natural Killer T cells Type I and Type II and their Role in Inflammatory Liver Disease such as Autoimmune Hepatitis
(Applicant
Arrenberg, Philomena
)
Lysosomale Lipase: Untersuchungen zur Struktur und Funktion, zur Gentherapie der Enzymdefizienz und zur Rolle des Enzyms in der Pathogenese der Arteriosklerose
(Applicant
Ameis, Detlev
)
Mechanismen der Asthmaresistenz durch regulatorische T-Zellen und TGFß1
(Applicant
Schramm, Christoph
)
Molecular pathogenesis and signaling pathways: identification of therapeutic targets in primary sclerosing cholangitis (PSC)
(Applicant
Schramm, Christoph
)
Origin and function of the endogenous danger signal HMGB1 in the inflammatory response following infectious and immunological liver injury.
(Applicant
Hübener, Peter
)
Protective function of PDGFR-alpha in intestinal Inflammation
(Applicant
Manthey, Carolin Friederike
)
Psychosoziale Risikofaktoren bei der Entstehung des postinfektiösen Reizdarmsyndroms: eine prospektive Kohortenstudie
(Applicant
Löwe, Bernd
)
Regulation of the activation status in T effector cells in blood and livers of patients with autoimmune hepatitis (AIH)
(Applicant
Sebode, Marcial
)
Regulatorische T-Zellen in der Therapie entzündlicher Lebererkrankungen
(Applicant
Schramm, Christoph
)
Role of the arylhydrocarbon receptor in hepatic immune regulation
(Applicant
Carambia, Antonella
)
Rolle nicht-parenchymatöser Leberzellen bei hepatischen Immunreaktionen
(Applicant
Herkel, Johannes
)
Tissue specific control of CD4+ T cells via IL-10 signaling
(Applicant
Huber, Samuel
)
Transmission Networks of Extended-spectrum beta-lactamase producing-Enterobacteriaceae in communities and hospitals in rural sub-Sahara Africa
(Applicant
Eibach, Daniel
)
Transplantation von Leberzellen für die Therapie Leber-basierter metabolischer Erkrankungen
(Applicant
Benten, Daniel
)
Untersuchung der Virus-Wirts Interaktionen im Laufe einer chronischen Koinfektion mit Hepatitis Delta und Hepatitis B Viren in uPA Mäusen
(Applicants
Dandri-Petersen, Maura
;
Lütgehetmann, Marc
)
Use of the upa chimeric mouse model for the study of hepadnaviral repliction and stability of cccDNA molecules
(Applicant
Petersen, Jörg
)
Research Fellowships
Completed projects
Analyse und Modulation CD4+CD25+Foxp3+ regulatorischer und IL-17 produzierender T-Zellen in murinen Colitismodellen anhand Foxp3-RFP/IL-17-GFP Reporter Mäuse
(Applicant
Huber, Samuel
)
Analysis of the interaction of Fusobacterium nucleatum and CEACAM1 and its impact on antitumor immunity
(Applicant
Galaski, Johanna
)
Characterization of genes involved in chromatin remodeling complexes and their functional role in hepatocarcinogenesis.
(Applicant
Schulze, Kornelius
)
DAMPs in hepatic fibrogenesis and carcinogenesis.
(Applicant
Hübener, Peter
)
Die Rolle des Tumorstromas bei hepatozellulären Karzinomen: Matrix, Fibroblasten und Makrophagen als neue Therapieziele?
(Applicant
Schrader, Jörg
)
Die Rolle von natürlichen Killer T Zellen in entzündlicher Lebererkrankung: Untersuchung des Schutzmechanismus vor Concanavalin-A induzierter Hepatitis
(Applicant
Arrenberg, Philomena
)
Funktion von IL-17 in Giardiasis: Identifizierung von IL-17-produzierenden Zellen, Induktionsmechanismen und Funktion von IL-17 im adaptiven Immunsystem in Giardiasis
(Applicant
Manthey, Carolin Friederike
)
Kupffer cell dysfunction in liver cirrhosis leads to uncontrolled infection
(Applicant
Peiseler, Moritz
)
"Liquid Biopsy" in Liver Cancer
(Applicant
von Felden, Johann
)
Mechanisms of maintenance CD8+ T cell memory responses (Memory Inflation) upon vaccination
(Applicant
Zinser, Madeleine Elisabeth
)
NLRP10 and adipocyte caspase-1 signalling protect against onset and progression of non-alcoholic fatty liver disease
(Applicant
Liwinski, Timur
)
Regulation der Leberrepopulation durch transplantierte Hepatozyten: Studien zu Zellinteraktionen mit Hepatischen Sternzellen
(Applicant
Benten, Daniel
)
The mycobiome and clinical outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation.
(Applicant
Rolling, Thierry
)
Heisenberg Professorships
Completed projects
Intestinal Immune Regulation
(Applicant
Huber, Samuel
)
Virus Hepatitis
(Applicant
Dandri-Petersen, Maura
)
Clinical Research Units
Completed projects
Analysis of the connection between inflammatory bowel disease and primary sclerosing cholangitis (PSC)
(Applicant
Huber, Samuel
)
Central Project
(Applicant
Lohse, Ansgar W.
)
Coordination Funds
(Applicant
Schramm, Christoph
)
Innate immune cells in the pathogenesis of PSC
(Applicants
Altfeld, Marcus
;
Herkel, Johannes
)
KFO 306: Primär Sklerosierende Cholangitis
(Spokesperson
Lohse, Ansgar W.
)
Neutrophil Extracellular Traps in the pathogenesis of PSC
(Applicant
Renné, Thomas
)
The intestinal and biliary microbiome in Primary Sclerosing Cholangitis (PSC)
(Applicants
Franke, Andre
;
Schramm, Christoph
)
Research Units
Current projects
Fatigue in Primary Biliary Cholangitis: Factors Associated With Severity and Persistence as Future Therapeutic Targets (RU SOMACROSS)
(Applicants
Schramm, Christoph
;
Toussaint, Ph.D., Anne
)
FOR 5068: Sex differences in immunity
(Spokesperson
Altfeld, Marcus
)
FOR 5211: Persistent Somatic Symptoms Across Diseases: From Risk Factors to Modification
(Spokesperson
Löwe, Bernd
)
Persistence of Gastrointestinal Symptoms in Irritable Bowel Syndrome and Ulcerative Colitis: From Risk Factors to Modification (RU SOMACROSS)
(Applicants
Lohse, Ansgar W.
;
Löwe, Bernd
)
The role of androgens in autoimmune liver diseases
(Applicant
Schramm, Christoph
)
Heisenberg Grants
Completed projects
Intestinal Immune Regulation
(Applicant
Huber, Samuel
)
Collaborative Research Centres
Current projects
Adenine nucleotide-modulated T cell differentiation and effector functions
(Project Heads
Huber, Samuel
;
Mittrücker, Hans-Willi
)
Humanized mice to study the zoonotic potential and pathophysiology of hepatotropic emerging pathogens
(Project Heads
Dandri, Maura
;
Rodriguez, Estefania
)
Integrated Research Training Group “Understanding emerging and re-emerging viruses”
(Project Heads
Dandri, Maura
;
Schulze zur Wiesch, Julian
)
Multidimensional analysis of protective and damaging adaptive immune responses in emerging viral infections
(Project Heads
Binder, Ph.D., Mascha
;
Schulze zur Wiesch, Julian
)
Protective early response patterns of innate cellular immune crosstalk in hemorrhagic fever virus infection
(Project Head
Hölzemer, Angelique
)
Public relations within the CRC “Emerging Viruses”
(Project Heads
Addo, Marylyn Martina
;
Lohse, Ansgar W.
)
Role of the ectonucleotidases CD39 and CD73 in immune responses to human viral infections
(Project Heads
Haag, Friedrich
;
Schulze zur Wiesch, Julian
)
Targeting Th17 cell adaptation in renal autoimmune diseases
(Project Heads
Huber, Samuel
;
Krebs, Christian
)
Completed projects
Central tasks
(Project Head
Lohse, Ansgar W.
)
Characterization of functional interactions between inflammatory and oncogene-permissive pathways in hepatocarcinogenesis
(Project Head
Wege, Henning
)
Die rolle von SLA/LP und anderen kranheitsspezifischen Autoantigenen in der Pathogenese der autoimmunen Hepatitis
(Project Head
Herkel, Johannes
)
(Dys)-regulation of the cellular HCV-specific immune response
(Project Head
Schulze zur Wiesch, Julian
)
From apoptotic cell sensing to an innate memory response: a new aspect of Kupffer cell function
(Project Head
Bosurgi, Ph.D., Lidia
)
Harnessing hepatic tolerance mechanisms for antigen-specific treatment of autoimmune and allergic diseases
(Project Heads
Carambia, Antonella
;
Heeren, Jörg
;
Herkel, Johannes
)
Hepatitis D Virus induced pathogenesis and interaction with the immune system
(Project Heads
Dandri-Petersen, Maura
;
Lütgehetmann, Marc
)
Hepatocellular Carcinoma - Analysis of malignant transformation by retroviral gene transfer
(Project Heads
Benten, Daniel
;
Fehse, Boris
)
Hepatocyte-dependent mechanisms of T cell exhaustion in chronic viral hepatitis
(Project Heads
Oxenius, Annette
;
Wiegard, Christiane
)
IL-22 and IL-22BP in liver regeneration and carcinogenesis
(Project Head
Huber, Samuel
)
Induction and breaking of immune tolerance in the liver
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
Influence of hepatic lipid profiles on inflammation, fibrogenesis and carcinogenesis in the liver
(Project Head
Kluwe, Johannes
)
In vivo Funktion der Lysosomalen Lipase in transgenen und homozygot defizienten Mäusen
(Project Head
Ameis, Detlev
)
Mechanisms underlying and consequences of hepatic and intestinal manifestations of COVID-19
(Project Heads
Altfeld, Marcus
;
Huber, Samuel
)
Molecular mechanisms of hepatitis B virus persistence in chronically infected human chimeric mice
(Project Head
Dandri-Petersen, Maura
)
Phenotype and function of CD4+ T lymphocytes in autoimmune hepatitis
(Project Head
Weiler-Normann, Christina
)
Public Relations Work within the Collaborative Research Centre 841
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
Regulation of the T cell response during malaria
(Project Heads
Jacobs, Ph.D., Thomas
;
Mackroth, Maria Sophia
)
Regulatory T cells and TH17 cells in experimental cholangitis
(Project Head
Schramm, Christoph
)
Role of the aryl hydrocarbon receptor in hepatic immune regulation
(Project Head
Carambia, Antonella
)
Rolle der Antigen-Präsentation in der Leber für die Viruspersistenz
(Project Heads
Herkel, Johannes
;
Lohse, Ansgar W.
)
SFB 841: Liver Inflammation: Infection, Immune Regulation and Consequences
(Spokesperson
Lohse, Ansgar W.
)
Toleranzentstehung und Toleranzdurchbrechung in der Leber
(Project Heads
Kanzler, Stephan
;
Lohse, Ansgar W.
)
Clinical Trials
Current projects
Radiofrequency ablation via catheter and transpapillary access in patients with cholangiocarcinoma (ACTICCA-2)
(Applicant
Wege, Henning
)
WBP Fellowship
Current projects
Deciphering the developmental requirements of CD4+ tissue-resident memory T cells
(Applicant
Poch, Tobias
)
Ectopic Lymphoid Structures – reducing the spatio-temporal unit to provide effective local immunity by TRM in non-lymphoid tissues?
(Applicant
Krause, Jenny
)
The role of intrahepatic regulatory T cells in immunotherapy of liver cancer
(Applicant
Kocheise, Lorenz
)
The role of microbiota-driven T-cell immunity for intestinal inflammation in alcohol-associated liver disease
(Applicant
Harberts, Aenne
)
Completed projects
Analysis of T cell receptor heterogeneity in healthy individuals and inflammatory bowel disease and its interaction with microbial composition
(Applicant
Ergen-Behr, Can
)
Major Research Instrumentation
Completed projects
5-Laser Flow cytometer
CRC/Transregios
Current projects
Intestinal metabolites and their impact on thermogenic responses by brown and white adipose tissues
(Project Heads
Heeren, Jörg
;
Schwinge, Dorothee
)
Regulation of energy metabolism in brown fat through lipid uptake and lipid processing in adipose tissue macrophages
(Project Heads
Bosurgi, Ph.D., Lidia
;
Worthmann, Anna
)
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