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Institution
Universitätsklinikum Essen
Zentrum für innere Medizin
Klinik für Hämatologie und Stammzelltransplantation
Address
Hufelandstraße 55
45147 Essen
Deutschland
GERiT
This institution in GERiT
45147 Essen
Projects
Research Fellowships
Completed projects
Identifikation von PIK1 Substrat interagierenden phosphopeptidbindenden Domänen und Proteinen
(Applicant
Reinhardt, Christian
)
Neue Regulatorgene der embryonalen Gefäßentwicklung und Morphogenese: Nachweis und Funktion mittels Gene-trap
(Applicant
Bücker, Markus
)
Regulierte Deletion des SCL-Gens mit Hilfe des cre/loxP-Rekombinase-Systems in verschiedenen Stadien der Hämatopoese
(Applicant
Göthert, Joachim Rudolf
)
Telomerlänge, Telomeraseaktivität und Telomerlokalisation in hämatopoetischen Zellen und Knochenmarkstromazellen bei hämatologischen Systemerkrankungen
(Applicant
Röth, Alexander
)
The leukemic stem cell niche - parallels to its physiological counterpart
(Applicant
Hanoun, Maher
)
To dissect the role of the alarmins S100A8/S100A9 in bone marrow fibrosis and clonal evolution in myeloproliferative neoplasms
(Applicant
Leimkühler, Nils
)
Research Grants
Current projects
Implications of the serine protease HTRA1 in Light Chain Amyloidosis
(Applicants
Carpinteiro, Alexander
;
Ehrmann, Michael
)
Mechanisms of humoral immune dysfunction in CLL
(Applicants
Knittel, Ph.D., Gero
;
Küppers, Ralf
)
Molecular classification and dynamic prognostication of Diffuse Large B Cell Lymphoma (DLBCL) by circulating cell-free DNA sequencing
(Applicants
Borchmann, Sven
;
von Tresckow, Bastian
)
Completed projects
Dual checkpoint blockade for the treatment of KRAS- or BRAF-driven neoplastic disease
(Applicant
Reinhardt, Christian
)
Einfluss des Hedgehog Signalweges auf die Funktion hämatopoetischer Stammzellen
(Applicant
Göthert, Joachim Rudolf
)
Long-read sequencing of SF3B1 mutated and wildtype chronic lymphocytic leukemia and myelodysplastic syndrome to identify mechanisms of genomic instability and therapy resistance and their impact on prognosis.
(Applicants
Beyer, Andreas
;
Herwig, Ralf
;
Schweiger, Michal-Ruth
)
Regulation of hematopoiesis and leukemogenesis through the hematopoietic stem cell niche in chronic lymphocytic leukemia
(Applicant
Hanoun, Maher
)
The role of mesenchymal stromal cells for the hematopoietic insufficiency in myelodysplastic syndromes
(Applicant
Schroeder, Thomas
)
The role of the hypoxic-response-pathway in thymic epithelial cells for thymic development, function and recovery from antineoplastic therapy
(Applicant
Göthert, Joachim Rudolf
)
Understanding mechanisms of drug resistance and clonal evolution in diffuse large B cell lymphoma
(Applicant
Reinhardt, Christian
)
Using mouse models to identify actionable molecular liabilities in Cluster 5 DLBCL
(Applicant
Reinhardt, Christian
)
Independent Junior Research Groups
Current projects
Longitudinal Analysis and Therapeutic Exploitation of Radiotherapy Resistance Mechanisms in Gliomas [R2-GLIO]
(Applicant
Kocakavuk, Emre
)
Completed projects
In vivo Charakterisierung der Protein Kinase MK2 als potenzielles Zielmolekül für eine neue Chemotherapie-sensitivierende Krebstherapie
(Applicant
Reinhardt, Christian
)
Clinical Research Units
Completed projects
Coordination and administration of the Clinical Research Unit
(Applicant
Reinhardt, Christian
)
Development of synergistic combination regimens for the treatment of chemotherapy-resistant high-risk CLL
(Applicant
Reinhardt, Christian
)
KFO 286: Exploiting Defects in the DNA Damage Response for the Treatment of Chronic Lymphocytic Leukemia
(Spokesperson
Hallek, Michael
)
Collaborative Research Centres
Current projects
Identification and characterization of molecular vulnerabilities in SCLC
(Project Heads
Beleggia, Filippo
;
Reinhardt, Christian
;
Wunderlich, Frank Thomas
)
Targeting oncogene-induced DNA repair pathway switches
(Project Head
Reinhardt, Christian
)
Using autochthonous mouse models of aggressive lymphoma to systematically distill actionable vulnerabilities
(Project Head
Reinhardt, Christian
)
Completed projects
Harnessing molecular vulnerabilities to promote an antitumor immune microenvironment
(Project Heads
Herter-Sprie, Grit Sophie
;
Reinhardt, Christian
)
MK2-dependent cytokine release in the tumor microenvironment
(Project Head
Reinhardt, Christian
)
Phosphorylation-dependent regulation of AATF controls p53-dependent apoptosis in the UV-induced DNA damage response of the skin
(Project Heads
Benzing, Thomas
;
Reinhardt, Christian
)
Regulation der Proliferation von Leukämiezellen: Stimulation durch Stromafaktoren und aberrante Genaktivierung in murinen Modellsystemen und beim Menschen
(Project Head
Dührsen, Ulrich
)
CRC/Transregios
Completed projects
The impact of HCV and HIV on human B cells and its role in B cell lymphoproliferative disorders
(Project Heads
Dürig, Jan
;
Küppers, Ralf
)
The impact of hepatitis C virus on human B cells and its role in B cell lymphoproliferative disorders
(Project Heads
Dürig, Jan
;
Küppers, Ralf
)
Research Training Groups
Current projects
GRK 2578: Impact of genotoxins on the differentiation efficacy of murine and human stem and progenitor cells and functional competence of thereof derived differentiated progeny
(Spokesperson
Fritz, Gerhard
)
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