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Institution
Charité - Universitätsmedizin Berlin
Charité Campus Mitte
Institut für Pathologie
Address
Charitéplatz 1
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Research Grants
Current projects
Investigation of ERK Activity as a Proxy for Targeted Therapy Resistance in KRAS-mutant Colorectal Cancer
(Applicant
Morkel, Markus
)
Reverse engineering of the transcriptional network downstream of RAF/MAPK signaling
(Applicants
Blüthgen, Nils
;
Böttcher, Michael
)
Tracking the evolution of therapy resistance in colorectal cancer.
(Applicant
Mamlouk, Ph.D., Soulafa
)
Completed projects
Chemoresistenzmechanismen beim humanen malignen Melanom
(Applicant
Lage, Hermann
)
Chemoresistenzmechanismen beim humanen malignen Melanom
(Applicant
Schadendorf, Dirk
)
Development of a YB-1 dependent Virotherapy for the treatment of non-muscle invasive bladder cancer
(Applicants
Holm, Per Sonne
;
Nawroth, Roman
)
Gemom-weite Matrix-CGH-Analyse des klassischen Hodgkin Lymphoms
(Applicant
Stein, Harald
)
Gibt es einen Morbus Hodgkin vom T-Zelltyp? Nachweis von T-Zellrezeptor-Gamma Genumlagerungen in einzelnen Hodgkin und Reed-Sternberg-Zellen
(Applicant
Stein, Harald
)
In vivo Charakterisierung von Tumorstammzellen des menschlichen Kolonkarzinoms
(Applicant
Horst, David
)
Kopplung der Transkription mit der Translation - Bedeutung für die Tumorentstehung und -progression am Beispiel des multifunktionellen Regulators YB-1
(Applicant
Jürchott, Karsten
)
Modulation atypischer "Multidrug Resistenzen" (MDR) mittels "Multitarget-Multiribozymen"
(Applicant
Lage, Hermann
)
Myeloide Dendritische Zellen des Empfängers in der allogenen Knochenmarkstransplantation: Überleben, Funktion, Migration und Eradikation in vivo.
(Applicant
Schulz, Stephan
)
Struktur/Wirkevaluierung von neuen "Multidrug-Resistance" (MDR)-Modulatoren in vitro und in vivo
(Applicants
Hilgeroth, Andreas
;
Kloft, Charlotte
;
Lage, Hermann
)
Systematic analyses of CTNNB1-, BRAF-, KRAS- and PIK3CA-induced oncogenic activities in the intestinal epithelium
(Applicant
Morkel, Markus
)
Collaborative Research Centres
Current projects
Targeted phosphoproteomics-based prediction of drug responses to combinatorial treatment
(Project Heads
Blüthgen, Nils
;
Selbach, Matthias
)
Targeting rewired ALK/RAS/MAPK signaling in neuroblastoma
(Project Heads
Blüthgen, Nils
;
Schulte, Johannes Hubertus
)
The Neuroblastoma Evolution integrated research training group
(Project Heads
Blüthgen, Nils
;
Künkele-Langer, Annette
)
Completed projects
Analyse der TNF-Rezeptor-assoziierten Signaltransduktionswege in den Tumorzellen von CD30+-Lymphomen
(Project Heads
Dürkhop, Horst
;
Stein, Harald
)
Charakterisierung von Resistenzgenen gegen die maligne Transformation durch Onkogene
(Project Heads
Schäfer, Reinhold
;
Sers, Christine
)
Correlation between regulatory DNA sequences and gene expression data based on the comparative analysis of non-coding regions between human and mouse
(Project Heads
Sers, Christine
;
Vingron, Martin
)
Humane Antikörper-Fusionsproteine zur Therapie des diffusen Magenkarzinoms
(Project Heads
Hummel, Michael
;
Stein, Harald
)
Modelling of signalling cascades - the impact of the RAS pathway on transcriptional targets
(Project Heads
Blüthgen, Nils
;
Schäfer, Reinhold
)
Wechselwirkung zwischen Chemo- und Thermoresistenz in vitro: Charakterisierung der Resistenzmechanismen
(Project Heads
Anderer, Ursula
;
Dietel, Manfred
;
Jordan, Andreas
;
Lage, Hermann
)
Clinical Research Units
Completed projects
Ursachen und Wirkungen von Transkriptionsfaktordefekten beim Morbus Hodgkin
(Applicant
Jundt, Franziska
)
Ursachen und Wirkungen von Transkriptionsfaktordefekten beim Morbus Hodgkin
(Applicant
Emmerich, Florian
)
CRC/Transregios
Completed projects
Analysis of a SUMO switch in EGF receptor signaling
(Project Heads
Blüthgen, Nils
;
Melchior, Frauke
)
Bedeutung von klonalen T-Zell-Expansionen und funktionellen T-Zellveränderungen bei Myokarditis und dilatativer Kardiomyopathie für die Pathogenese, Prognose und den Verlauf immunmodulatorischer Therapien
(Project Heads
Hummel, Michael
;
Noutsias, Michel
;
Volk, Hans-Dieter
)
Epigenetic Components of cellular Transdifferentiation in molecular Pathogenesis of Hogdkin Lymphoma and diffuse large B Cell Lymphoma
(Project Heads
Hummel, Michael
;
Stein, Harald
)
Histomorphological analysis of T cells and the microenvironment in situ
(Project Heads
Loddenkemper, Christoph
;
Schulz, Stephan
)
Translation of Model-based Findings to primary human lymphoid Neoplasia
(Project Heads
Hummel, Michael
;
Stein, Harald
)
Research Fellowships
Completed projects
Cell-cycle checkpoint inhibitors as a novel anti-cancer strategy in Glioblastoma multiforme
(Applicant
Dubois, Frank
)
Integration of DNA- and RNA- based methods for prediction of response and survival after neoadjuvant chemotherapy for breast cancer
(Applicant
Sinn, Bruno Valentin
)
Isolierung von Tumorstammzellen aus Kolonkarzinomen
(Applicant
Horst, David
)
Th17 pathways in age-dependent alloimmune responses: mechanisms and therapeutic approaches
(Applicant
Heinbokel, Timm
)
Understanding the mechanism of action of classic cytotoxic chemotherapeutic agents using intravital live-cell imaging in mice
(Applicant
Florian, Stefan
)
Priority Programmes
Completed projects
Information flow in a mammalian signal transduction pathway
(Applicants
Blüthgen, Nils
;
Loewer, Alexander
)
Major Research Instrumentation
Completed projects
Confocal spinning disk high throughput screening microscope
Research Units
Current projects
FOR 5628: Multiscale magnetic resonance elastography in cancer: The mechanical niche of tumor formation and metastatic spread – towards an improved diagnosis of cancer through mechanical imaging
(Spokesperson
Sack, Ingolf
)
Interplay of mechanical properties of tissue microenvironment, oncogenic signaling, and metabolism in hepatopancreatic cancer
(Applicants
Berndt, Nikolaus
;
Sers, Christine
)
Research data and software
Completed projects
Leistungszentren: Entwicklung und Evaluation eines Offenen Europäisch-Wissenschaftlichen Zentrums für Klinik, Pathologie, Lehre und Forschung in Nephrologie und nephrologischer Transplantationsmedizin (Open European Nephrology Science Center - OpEN.SC)
Research Training Groups
Current projects
GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
(Spokesperson
Blüthgen, Nils
)
Completed projects
GRK 1772: Computational Systems Biology
(Spokesperson
Klipp, Edda
)
Graduate Schools
Completed projects
GSC 1091: Berlin School of Integrative Oncology (BSIO)
(Spokespersons
Na, Il-Kang
;
Schmitt, Clemens A.
)
NFDI technical and methodological consortia
Current projects
GHGA – German Human Genome-Phenome Archive
(Spokesperson
Stegle, Ph.D., Oliver
)
National Research Data Infrastructure for Immunology
(Spokesperson
Busse, Christian
)
Additional Information
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