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Institution
Charité - Universitätsmedizin Berlin
Charité Campus Mitte
Institut für Biochemie
Address
Virchowweg 6
10117 Berlin
Deutschland
GERiT
This institution in GERiT
10117 Berlin
Projects
Priority Programmes
Current projects
MiMiCry: Mimicking Nature by Continuous Production of Antimicrobials in Mixed Cultures of Synthetic Strains
(Applicants
Lindner-Mehlich, Steffen
;
Takors, Ralf
)
Completed projects
Biochemical and functional analysis of multicatalytic proteinase subtypes in 20S and 26S proteasoms
(Applicant
Dahlmann, Burkhardt
)
Biochemical and functional characterization of ubiquitin-like proteines ISG15 and FAT10 in human dendritic cells.
(Applicant
Kloetzel, Peter Michael
)
Expression regulation of phospholipid hydroperoxide glutathione peroxidase isoforms. Transcriptional and post-transcriptional processes
(Applicant
Kühn, Hartmut
)
Functional characterization of ubiquitin-like modifier ISG15 in murine enterovirus myocarditis
(Applicant
Beling, Antje
)
Funktionelle Analyse der Proteasomregulatoren PI31, PA28y/Ki und warum PA28aß die Generierung von MHC Klasse I Epitopen unterstützt Functional analysis of proteasome regulators PI31, PA28y/Ki and why the PA28aß supports the generation of MHC class I antigens
(Applicant
Kloetzel, Peter Michael
)
Implications of ß-subunit exchanges and of interactions with the activator PA28 for the cleavage preferences of the 20S proteasome: A quantitative analysis based on kinetic experiments
(Applicant
Holzhütter, Hermann-Georg
)
SPP 1045: Struktur, Funktion und Regulation des 20S/26S Ubiquitin-Proteasomsystems
(Spokesperson
Kloetzel, Peter Michael
)
Untersuchungen zur strukturellen und funktionellen Plastizität des 20S/26S-Proteasoms und assoziierter regulatorischer Komplexe in Mikrogliazellen der Maus
(Applicant
Stohwasser, Ralf
)
Research Units
Current projects
FOR 5228: Membrane trafficking processes underlying presynaptic proteostasis
(Spokesperson
Kreutz, Michael R.
)
Presynaptic crosstalk of autophagy and proteasomal activity to maintain proteostasis
(Applicants
Eickholt, Britta
;
Kirstein, Janine
)
Completed projects
Glycosidierte Phospholipidanaloga als topische Dermatika und Inhibitoren des Tumorwachstums
(Applicant
Danker, Kerstin
)
Optimiertes ß-Faltblattmodul für die effektive Expression von Fab-Fragmenten in E.coli
(Applicant
Höhne, Wolfgang
)
Verwendung von Peptidbibliotheken zur Auffindung von Chitinaseinhibitoren und strukturelle Charakterisierung der Wechselwirkung
(Applicant
Höhne, Wolfgang
)
Research Grants
Current projects
Ageing, proteotoxic stress and the neuronal cytoskeleton: Analyses of the age-dependent challenges of the actin filament system
(Applicants
Eickholt, Britta
;
Kirstein, Janine
)
Detailing the Feedback Interplay between Phosphoinositides, Rho GTPases and Actin Governing Cell Polarisation
(Applicant
Rocks, Oliver
)
Shaping the glial scar during CNS injury by manipulating the actin cytoskeleton in astrocytes
(Applicant
Eickholt, Britta
)
Completed projects
Adaptation of proteasome composition in inflammatory response - the impact of the hybridproteasome
(Applicant
Beling, Antje
)
Allosteric lipoxygenase effectors as potential drugs
(Applicant
Kühn, Hartmut
)
Analyse der molekularen und biochemischen Mechanismen der Proteasomassemblierung
(Applicant
Kloetzel, Peter Michael
)
Die cytoplasmatischen Domänen der Kollagen-bindenden alpha-1 und alpha3-Integrinuntereinheiten: Ihre Funktion bei Adhäsion, Migration und Differenzierung von PC12-Zellen
(Applicant
Danker, Kerstin
)
Endolysosomal targeting of Protein Kinase A by ARHGAP36
(Applicant
Rocks, Oliver
)
Funktion von ISG15 bei viralen Herzmuskelerkrankungen
(Applicant
Beling, Antje
)
Influence of cytokines and infection on proteasomal antigen processing
(Applicant
Kuckelkorn, Ulrike
)
Investigation of the translational potential of the ISG15 system for treatment of virus-induced inflammatory cardiomyopathy.
(Applicant
Beling, Antje
)
Investigations into the Distribution, the Biological Role and the Evolution of Lipoxygenases. Functional Charcterization of Genetically Modified Mice with Humanized Reaction Specificity.
(Applicants
Heydeck, Dagmar
;
Kühn, Hartmut
)
Investigations into the role of eicosanoid synthesizing enzymes in foam cell formation and human atherogenesis
(Applicant
Kühn, Hartmut
)
Molecular and therapeutic aspects of proteolytic machineries in immune cells for cardiac inflammation.
(Applicants
Beling, Antje
;
Kaya, Ziya
)
Neuartige glycosidierte Phospholipidanaloga als topische Dermatika und Inhibitoren des Tumorwachstums
(Applicant
Danker, Kerstin
)
Oral Nanocarrier-based Anti-inflammatory Therapy (ORAL-NAIT) of Mucosal Diseases
(Applicants
Danker, Kerstin
;
Dommisch, Henrik
;
Haag, Rainer
)
Quantitative proteomics using novel trifunctionalized metal coded affintiy tags
(Applicant
Linscheid, Michael
)
Structural analysis of the anti-myc tag antibody 9E10 in complex with the c-myc epitope and the mutagenesis of the binding region for the characterization and optimization of the interaction
(Applicant
Höhne, Wolfgang
)
Strukturelle Ursachen für Positionsspezifität von Lipoxygenasen und für deren Fähigkeit zur Membranbindung
(Applicant
Kühn, Hartmut
)
Studies on the role of ALOX15 and its products in murine experimental colitis.
(Applicants
Kühn, Hartmut
;
Weylandt, Ph.D., Karsten-Henrich
)
The function of the Ubiquitin-Proteasome-System (UPS) in MHC class I antigen processing in target cells and maturing human dendritic cells (hDCs).
(Applicant
Kloetzel, Peter Michael
)
Transcription factor 11 (TCF 11) is a transcriptional regulator of proteasome subunit genes - what in turn regulates TCF 11 activation?
(Applicants
Koch, Annett
;
Krüger, Elke Beate
)
Untersuchung der Funktionsweise des HERP Proteins
(Applicant
Seeger, Michael
)
Untersuchung der Prozessierung von MHC-Klasse-I-restringierten Antigenen durch Selektion und Analyse von mutanten Melanomzellen mit defekter Antigenpräsentation
(Applicant
Kloetzel, Peter Michael
)
Untersuchungen zum Mechanismus und zur Regulation der Biosynthese des Hepoxilins A3 sowie über seine biologische Funktionen
(Applicant
Nigam, Santosh
)
Collaborative Research Centres
Current projects
Metabolic reprogramming steered by ISGylation in HFpEF
(Project Heads
Beling, Antje
;
Berndt, Nikolaus
)
Molecular technology infrastructure and support
(Project Heads
Altmüller, Janine
;
Lodrini, Marco
;
Ralser, Markus
)
Plasma proteome and metabolome signatures to better understand, monitor and predict neuroblastoma evolution
(Project Heads
Deubzer, Ph.D., Hedwig E.
;
Ralser, Markus
)
TF-PAR2 signaling in viral infections
(Project Heads
Beling, Antje
;
Ruf, Wolfram
)
Completed projects
Analyses of the function and regulation of the PTEN suppressor during early brain development
(Project Head
Eickholt, Britta
)
A PRG2-PTEN based membrane scaffold involved in the formation of axon branches
(Project Head
Eickholt, Britta
)
Bacterial [NiFe]-hydrogenases: key reactions of the biological activation of molecular hydrogen
(Project Heads
Friedrich, Bärbel
;
Höhne, Wolfgang
;
Krauß, Norbert
)
Das Proteasom in Mikroglia und Astrozyten und seine Rolle bei Infektiones- und Entzündungsprozessen im ZNS
(Project Heads
Dahlmann, Burkhardt
;
Kloetzel, Peter Michael
)
Einfluss von zytosolischen und im ER lokalisierten Aminopeptidasen auf die post-Proteasomale Generierung viraler MHC Klasse I Liganden
(Project Heads
Kloetzel, Peter Michael
;
Seifert, Ulrike
)
Geschäftsstelle
(Project Head
Kloetzel, Peter Michael
)
Integrin-vermittelte Signaltransduktion: Die funktionelle Bedeutung der cytoplasmatischen Domänen der a1- und a3-Integrin-Untereinheiten
(Project Head
Danker, Kerstin
)
Membrane biogenesis modelling of a Toxoplasma gondii-infected human cell and deduction of underlying metabolic principles
(Project Heads
Gupta, Nishith
;
Holzhütter, Hermann-Georg
;
Lucius, Richard
)
Multiparameter-Durchflußcytometrie zur Einzelzellsortierung
(Project Head
Danker, Kerstin
)
Neuronal excitation as a perturbation of the energetic and osmotic homeostasis: Implications for robust network behaviour
(Project Heads
Holzhütter, Hermann-Georg
;
Kann, Oliver
)
Regulation of proteasome modules
(Project Heads
Kloetzel, Peter Michael
;
Krüger, Elke Beate
)
Regulatorische Determinanten zur Produktion von MHC Klasse I-Liganden durch das Proteasomensystem
(Project Head
Kloetzel, Peter Michael
)
SFB 421: Protective and Pathological Effects of Antigen Processing
(Spokesperson
Kloetzel, Peter Michael
)
Zentrale Proteinchemie
(Project Head
Henklein, Peter
)
CRC/Transregios
Current projects
Metabolic switches regulating stress tolerance in eukaryotes
(Project Heads
Dick, Tobias
;
Ralser, Markus
)
USP18 as a key regulator for microglia activation
(Project Heads
Beling, Antje
;
Knobeloch, Klaus-Peter
)
Completed projects
Pathogen induced alterations of the Ubiquitin-Proteasome-System (UPS) during the Innate Immune Response in the Lung
(Project Heads
Kloetzel, Peter Michael
;
Seifert, Ulrike
)
Phosphoinositide switches in neurons: implications for membrane dynamics, axonal morphogenesis and the cortical actin cytoskeleton
(Project Head
Eickholt, Britta
)
Role of Proteasomes in Acute and Chronic Enterovirus Myocarditis
(Project Heads
Beling, Antje
;
Kloetzel, Peter Michael
;
Kuckelkorn, Ulrike
)
The role of immunoproteasomes and the ubiquitin system in inflammatory processes in mouse models of Alzheimer's and Parkinson's disease
(Project Heads
Aktas, Orhan
;
Heppner, Frank
;
Kloetzel, Peter Michael
;
Krüger, Elke Beate
)
Major Research Instrumentation
Completed projects
Hochauflösendes Flüssigkeitschromatographie-Massenspektrometriesystem (LC-MS)
Research Training Groups
Completed projects
GRK 80: Model Studies of Structures, Properties and Recognition of Biologically Relevant Molecules at Atomic Level
(Spokesperson
Höhne, Wolfgang
)
GRK 268: Dynamics and Evolution of Cellular and Macromolecular Systems
(Spokesperson
Heinrich, Reinhart
)
GRK 1772: Computational Systems Biology
(Spokesperson
Klipp, Edda
)
International Research Training Groups
Completed projects
GRK 1360: Genomics and Systems Biology of Molecular Networks
(Spokesperson
Klipp, Edda
)
GRK 1673: Functional Molecular Infection Epidemiology
(Spokesperson
Wieler, Lothar H.
)
Major Instrumentation Initiatives
Completed projects
Lattice Light Sheet Microscope (LLSM)
Clusters of Excellence
Completed projects
EXC 257: NeuroCure - Towards a Better Outcome of Neurological Disorders
(Spokesperson
Schmitz, Dietmar
)
Additional Information
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