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Institution
Universitätsklinikum Hamburg-Eppendorf
Zentrum für experimentelle Medizin
Institut für Biochemie und Signaltransduktion
Address
Martinistraße 52
20251 Hamburg
Deutschland
GERiT
This institution in GERiT
20251 Hamburg
Projects
Research Grants
Current projects
Time-resolved structural analysis of the extended spectrum beta-lactamase CTX-M-14
(Applicant
Schulz, Eike
)
Completed projects
Die Funktion der Inositolpolyphosphat-5`-Phosphatase SHIP für die Signaltransduktion hämatopoetischer Zellen und ihre Bedeutung für die humane Leukämogenese
(Applicant
Jücker, Manfred
)
Functional domains of inositol- 1,4,5 -trisphosphate- 3-kinases: regulation of enzyme activity and subcellular localization
(Applicant
Mayr, Georg W.
)
Mechanismen der Regulation der freien intrazellulären Ca2+-Konzentration durch Ca2+-Freisetzung und Ca2+-Einstrom in aktivierten T-Lymphozyten
(Applicant
Guse, Andreas H.
)
NMR-spektroskopische Aufklärung der räumlichen Struktur der DNA-bindenden Domäne des Proteins ARBP/MeCP2
(Applicant
Brunner, Eike
)
Occult serum PSA: Characterisation and evaluation as a marker for prostate tumors
(Applicant
Hilz, Helmuth
)
Role of the purine nucleotide messengers cyclic ADP-ribose and ADP-ribose in T-lymphocyte biology
(Applicant
Guse, Andreas H.
)
Systematic identification and characterization of missing GEFs for GTPases
(Applicants
Goody, Roger S.
;
Itzen, Aymelt
)
Collaborative Research Centres
Current projects
Functional and structural analysis of the nucleotide-activated ion channel TRPM2
(Project Heads
Fliegert, Ralf
;
Garcia Alai, Ph.D., Maria Marta
;
Tidow, Henning
)
Targeting the ADPR-binding macrodomain associated deMARylation/dePARylation enzyme activity as novel approach towards SARS-CoV-2
(Project Heads
Fliegert, Ralf
;
Meier, Chris
;
Pfefferle, Susanne
)
Completed projects
Analyse der transkriptionellen Repression und DNA-Bindung von MeCP2 und ihrer Bedeutung für das Rett-Syndrom
(Project Head
Strätling, Wolf H.
)
Structural dynamics of small GTPases under the influence of posttranslational modifications
(Project Head
Itzen, Aymelt
)
Research Units
Completed projects
Role of Ca2+ mobilizing second messenger NAADP in local and global Ca2+ signalling in mouse cardiac myocytes
(Applicant
Guse, Andreas H.
)
Priority Programmes
Completed projects
Application of an enzymatic protein labeling strategy based on CDP-choline analogues
(Applicant
Itzen, Aymelt
)
Major Research Instrumentation
Completed projects
Mass spectrometer LC-ESI-MS UHR QTOF
WBP Fellowship
Current projects
Impact of Argonaute 2 (AGO2) PAZ domain mutations on miRNA turnover, target interaction and tumour development
(Applicant
Nelson, Nina Caroline
)
Research Training Groups
Current projects
GRK 2771: Humans and Microbes: Reorganisation of Cell Compartments and Molecular Complexes during Infection
(Spokesperson
Aepfelbacher, Martin
)
Completed projects
GRK 255: Signal Transduction in the Nervous System and its Pathology
(Spokesperson
Schachner, Melitta
)
GRK 336: Molecular Endocrinology - Molecular Metabolism
(Spokesperson
Seitz, Hans-Joachim
)
GRK 464: Glycoconjugates: Synthesis, Analysis, Structure and Function
(Spokesperson
Meyer, Bernd
)
Additional Information
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