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Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
Nikolaus-Fiebiger-Zentrum für Molekulare Medizin
Lehrstuhl für Experimentelle Medizin I
Address
Glückstraße 6
91054 Erlangen
Deutschland
GERiT
This institution in GERiT
91054 Erlangen
Projects
Priority Programmes
Current projects
Zeb1-mediated mechanisms of the EMT-associated ferroptosis sensitivity
(Applicants
Brabletz, Thomas
;
Brabletz, Simone
)
Completed projects
Analysis of Laminin - alpha7beta1 Integrin Interactions: Ligand specificity and Binding sites
(Applicant
von der Mark, Ph.D., Klaus
)
Biochemical and functional analysis of laminin isoforms, laminin-5, -6 and -7
(Applicant
Sasaki, Takako
)
In vivo contributions of collagen IV for structure, stability and function of basement membranes
(Applicant
von der Mark, Ph.D., Klaus
)
Research Grants
Completed projects
Analyse der in-vivo Funktion von Annexin A5
(Applicant
Pöschl, Ernst
)
Analysing the Role of Growth Plate Specific Genes in Endochondral Ossification by Specific Overexpression or Deletion under the BAC Col10a1 Promoter
(Applicant
von der Mark, Ph.D., Klaus
)
Cancer promoting transcriptional enhancers controlled by the EMT-activator ZEB1
(Applicants
Brabletz, Thomas
;
Brabletz, Simone
)
Chemically Modified Nanoporous Titanium Oxide for Biomedical Applications
(Applicants
von der Mark, Ph.D., Klaus
;
Schmuki, Patrik
)
Development of a cantilever sensor chip as a point-of-care (POC) device for label-free, rapid, and multiplexed detection of cancer protein biomarkers
(Applicant
Urban, Gerald A.
)
Die Rolle der microRNA-200 Familie in der Tumorinvasion und Metastasierung
(Applicant
Brabletz, Thomas
)
Die Rolle des EMT-Aktivators ZEB1 bei Verlust von Zellpolarität und Akkumulation von Tumorstammzellen in kolorektalen Karzinomen
(Applicant
Brabletz, Thomas
)
Die Rolle von Twisted Gastrulation in der Chondrocytendifferenzierung und Skelettentwicklung
(Applicant
von der Mark, Ph.D., Klaus
)
Interaction of the EMT-activator ZEB1 and the Yap/Taz/Hippo-pathway in cancer
(Applicant
Brabletz, Thomas
)
Role of the EMT activator ZEB1 in pancreatic cancer invasion, dissemination and metastasis
(Applicants
Brabletz, Thomas
;
Brabletz, Simone
)
The role of fibulin-4 in development and homeostasis of elastic components of the skeletal connective tissue
(Applicant
von der Mark, Ph.D., Klaus
)
The role of the oncoprotein ß-Catenin for invasion and metastasis formation of colorectal carcinomas
(Applicant
Brabletz, Thomas
)
Zelluläre Interaktionen mit Matrix-beschichteten biomimetischen Materialien
(Applicant
von der Mark, Ph.D., Klaus
)
Reinhart Koselleck Projects
Current projects
Targeting the roots of cancer metastasis and therapy resistance
(Applicant
Brabletz, Thomas
)
Collaborative Research Centres
Completed projects
Epigenetics and therapeutic options of EMT-associated drug resistance in pancreatic cancer
(Project Heads
Brabletz, Thomas
;
Keck, Tobias
)
Molekulare Grundlagen von Integrin-vermittelten Zell-Matrix-Interaktionen bei Entzuendungsprozessen
(Project Head
von der Mark, Ph.D., Klaus
)
NF-AT-Faktoren als Regulatoren der Expression pro- und anti-apoptischer Gene in Lymphozyten
(Project Heads
Brabletz, Thomas
;
Serfling, Edgar
)
Regulation der Transkription des Typ X Kollagen Gens durch Parathormon und Thyroxin
(Project Heads
von der Mark, Ph.D., Klaus
;
Pöschl, Ernst
)
Regulation der Zellmigration auf Laminin durch A7b1-Integrin vermittelte Signalkaskaden
(Project Heads
von der Mark, Ph.D., Klaus
;
Pöschl, Ernst
)
Role of the EMT activator ZEB1 in pancreatic cancer invasion, dissemination and metastasis
(Project Heads
Brabletz, Thomas
;
Brabletz, Simone
)
The role of the cadherin switch compared to Zeb1-dependent EMT in embryogenesis and tumor formation
(Project Heads
Brabletz, Thomas
;
Stemmler, Marc
)
Research Fellowships
Completed projects
Rho-GTPases and Muscle Differentiation: Spatio-Temporal Control of Rac1-Activity and Specific Signaling Pathways
(Applicant
Samson, Thomas
)
Research Units
Completed projects
FOR 2438: Cell Plasticity in Colorectal Carcinogenesis
(Spokesperson
Greten, Florian R.
)
The role of the EMT-inducer Zeb1 in the invasive tumor stroma during colon cancer progression
(Applicants
Brabletz, Thomas
;
Farin, Henner
)
The role of the EMT-inducer Zeb1 in the invasive tumor stroma during colon cancer progression
(Applicants
Brabletz, Thomas
;
Farin, Henner
)
CRC/Transregios
Current projects
Metabolic dysregulations in EMT-driven metastatic colonisation
(Project Heads
Brabletz, Thomas
;
Mougiakakos, Dimitrios
)
Zeb1 expressing macrophages control metastatic colonisation
(Project Head
Brabletz, Thomas
)
Research Training Groups
Completed projects
GRK 805: Protein-Protein Interactions in Signal Transduction
(Spokesperson
Hillen, Wolfgang
)
Additional Information
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