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Institution
Universitätsklinikum Gießen und Marburg
Standort Gießen
Medizinische Klinik II
Department of Molecular Pneumology
Address
Aulweg 130
35392 Gießen
Deutschland
GERiT
This institution in GERiT
35392 Gießen
Projects
Research Grants
Completed projects
Die Rolle von Cytochrom P450-abgeleiteten Eicosanoiden in der Pathogenese der pulmonalen Hypertonie des Menschen
(Applicant
Kiss, Ladislau
)
Die Rolle von "transient receptor potential (TRP)"-Kanälen bei der Hypoxie-induzierten pulmonalen Hypertonie und beim vaskulären Gefäßumbau
(Applicant
Dietrich, Alexander
)
FGF10/FGFR2b signaling in lung emphysema as a target for lung regeneration
(Applicants
Bellusci, Saverio
;
Weißmann, Norbert
)
Identification of the superoxide source of tobacco-smoke-induced emphysema and pulmonary hypertension, pathogenesis and regeneration.
(Applicant
Weißmann, Norbert
)
Interaction of ROS sources, mitochondrial biogenesis and redox-signaling in pulmonary hypertension.
(Applicant
Weißmann, Norbert
)
Investigating sestrin 2 (sesn2) control of TGF-beta, mTOR and PDGF signaling and its potential significance in the development of chronic obstructive pulmonary disease (COPD)
(Applicants
von Melchner, Ph.D., Harald
;
Weißmann, Norbert
)
Tyrosine kinase inhibition in pulmonary hypertension: experimental and clinical studies
(Applicant
Ghofrani, Hossein Ardeschir
)
Vaskuläre NADPH-Oxidase-Expression in einem Mausmodell der obstruktiven Schlaf-Apnoe
(Applicant
Schulz, Richard
)
Research Units
Current projects
Epigenetic-metabolic contribution to inflammatory phenotypes of CH in pulmonary hypertension (Project A3)
(Applicant
Savai Pullamsetti, Soni
)
FOR 5643: Clonal hematopoiesis: Pathomechanisms and clinical consequences in the heart and blood
(Spokesperson
Rieger, Michael
)
Collaborative Research Centres
Current projects
Central tasks, management and coordination
(Project Head
Weißmann, Norbert
)
FOXO transcription factors in PH: critical integrators of multiple immune signaling pathways driving pulmonary vascular and right ventricular remodeling
(Project Heads
Dobreva, Gergana
;
Savai Pullamsetti, Soni
)
Inflammatory lung microenvironment in lung cancer-associated pulmonary hypertension
(Project Heads
Ghofrani, Hossein Ardeschir
;
Grimminger, Friedrich
;
Schermuly, Ralph
;
Weiß, Astrid
)
iNOS- and NoxO1-based redox signaling in chronic obstructive pulmonary disease (COPD) associated PH – pathomechanisms and therapeutic exploitation
(Project Heads
Gredic, Ph.D., Marija
;
Weißmann, Norbert
)
Regulatory network of histone modifications in human pulmonary arterial hypertension
(Project Heads
Bauer, Uta-Maria
;
Savai Pullamsetti, Soni
)
Right ventricular (RV) function in pulmonary hypertension and impact of targeted interventions on RV-PA (pulmonary artery) coupling
(Project Heads
Ghofrani, Hossein Ardeschir
;
Seeger, Werner
;
Tello, Khodr
)
Sensing and signaling events underlying development and recovery of hypoxia-induced pulmonary hypertension
(Project Heads
Sommer, Ph.D., Natascha
;
Weißmann, Norbert
)
SFB 1213: Pulmonary Hypertension and Cor Pulmonale
(Spokesperson
Weißmann, Norbert
)
Completed projects
Charakterisierung des Ischämie-Reperfusionssyndroms der Lunge und Entwicklung von Strategien zur therapeutischen Beeinflussung
(Project Heads
Ghofrani, Hossein Ardeschir
;
Grimminger, Friedrich
)
Charakterisierung von Sensor- und Effektormechanismus der vaskulären Widerstandserhöhung bei akuter und chronischer alveolärer Hypoxie
(Project Head
Weißmann, Norbert
)
Deep phenotyping combined with genomic, proteomic and metabolomic analyses in Kyrgyz highlanders – association with high altitude adaptation
(Project Heads
Ghofrani, Hossein Ardeschir
;
Wilkins, Martin
)
NADPH-Oxidassen als molekulare Quelle von oxidativem Stress im kardiopulmonalen Blutgefäßsystem
(Project Heads
Schmidt, Harald
;
Weißmann, Norbert
)
Rolle von Phosphodiesterase-5 Inhibition in der Behandlung der chronisch thromboembolischen pulmonalen Hypertonie: Einfluss auf die pulmonale Hämodynamik und das rechtskardiale Remodeling
(Project Heads
Braun, Thomas
;
Ghofrani, Hossein Ardeschir
)
The role of HIF-1 and its regulators p53 and Smyd2 in right ventricular hypertrophy and failure
(Project Heads
Novoyatleva, Tatyana
;
Schermuly, Ralph
)
Priority Programmes
Completed projects
Signalverarbeitung und Zelldifferenzierung des Alveolarepithels - Einfluß physiologischer und medikamentöser Stimuli sowie inflammatorischer Mediatoren
(Applicant
Ghofrani, Hossein Ardeschir
)
Clinical Research Units
Completed projects
Role of Phosphodiesterases in Lung Fibrosis - Pathogenetic Mechanisms and Therapeutic Options
(Applicant
Savai Pullamsetti, Soni
)
CRC/Transregios
Completed projects
Lung protection in severe COVID-19 by means of Tie2 agonism
(Project Heads
Weißmann, Norbert
;
Witzenrath, Martin
)
Research Training Groups
Completed projects
GRK 534: Biological Basis of Vascular Medicine
(Spokesperson
Piper, Hans Michael
)
International Research Training Groups
Completed projects
GRK 1062: Signalling Mechanisms in Lung Physiology and Disease (SMLPD)
(Spokesperson
Seeger, Werner
)
Clusters of Excellence
Completed projects
EXC 147: Cardio-Pulmonary System
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
;
Zeiher, Andreas Michael
)
Clusters of Excellence (ExStra)
Current projects
EXC 2026: Cardio-Pulmonary Institute (CPI)
(Spokespersons
Dimmeler, Stefanie
;
Seeger, Werner
)
Additional Information
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