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Institution

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Johannes Gutenberg-Universität Mainz
Institut für Pharmazeutische und Biomedizinische Wissenschaften

Address Staudinger Weg 5
55128 Mainz
Deutschland

GERiT This institution in GERiT

55128 Mainz

Projects

Research Grants
- Current projects
  - Dihydrouridine RNA modification marks: written and erased by the same enzyme
    (Applicant Helm, Mark )
- Completed projects
Research Units
- Completed projects
  - RNA-Substrate Sepcificity of Dnmt2
    (Applicant Helm, Mark )
Priority Programmes
- Completed projects
  - Coordination Funds
    (Applicant Helm, Mark )
  - Detection and Identification of new RNA modifications
    (Applicant Helm, Mark )
  - Identification and characterization of RNA modifications with immune-modulatory properties acting on Toll-like receptors
    (Applicants Dalpke, Alexander ; Helm, Mark )
  - SPP 1784: Chemical Biology of native Nucleic Acid Modifications
    (Spokesperson Helm, Mark )
Major Research Instrumentation
- Completed projects
  - Massenspektrometer mit Hochleistungs-Flüssigchromatographie (HPLC-MS)
  - Triple-quadrupol mass spectrometer (LC-MS)
CRC/Transregios
- Current projects
  - C03 Mass spectrometry of RNA and proteins in modified RNPs
    (Project Heads Butter, Falk ; Helm, Mark ; Jäschke, Andres )
  - Central Task of the Collaborative Research Center
    (Project Head Helm, Mark )
  - Dynamics of modifications and processing of RNAs in the flavivirus replication cycle
    (Project Heads Helm, Mark ; Ruggieri, Ph.D., Alessia )
  - Mismodification of tRNA in no-go decay and other co-translational quality control pathways
    (Project Head Winz, Marie-Luise )
  - Novel modification mapping techniques and efficient RNA-Seq data management
    (Project Heads Helm, Mark ; Hildebrandt, Andreas ; Schmidt, Bertil )
  - TRR 319: RMaP: RNA Modification and Processing
    (Spokesperson Helm, Mark )
Collaborative Research Centres
- Current projects
  - Modulation of the tumor microenvironment by addressing inhibitory (immune) cells via time-programmed and self-regulating liposome
    (Project Heads Helm, Mark ; Tüttenberg, Andrea Renate ; Walther, Andreas )
- Completed projects
  - Liposomes and polymersomes with multifunctional endgroups: targeting and controlled release
    (Project Heads Frey, Holger ; Helm, Mark ; Zentel, Rudolf )
  - RNA-loaded functionalized nanoparticles for inhibition of tumour-associated regulatory T cells and antigen loading of human dendritic cells
    (Project Heads Helm, Mark ; Jonuleit, Helmut )

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