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Institution
Universität zu Lübeck
Sektion Medizin
Institut für Systemische Entzündungsforschung
Address
Ratzeburger Allee 160
23562 Lübeck
Deutschland
GERiT
This institution in GERiT
23562 Lübeck
Projects
Research Grants
Current projects
Age-associated-susceptibility to B cell autoimmunity in murine epidermolysis bullosa acquisita
(Applicant
Manz, Rudolf
)
Complement as driver of neuroinflammation and -degeneration in Parkinson‘s disease
(Applicants
Köhl, Jörg
;
Seibler, Philip
)
The role of house dust mite allergens - structural and functional analysis in the context of atopic diseases
(Applicants
Jappe, Uta
;
Traidl, Stephan
)
Completed projects
B Cell Autoimmunity in ApoE-deficient (ApoE-/-) Mice
(Applicants
Habenicht, Andreas J.R.
;
Yin, Ph.D., Changjun
)
Charakterisierung von Plasmazell-Überlebensnischen
(Applicant
Manz, Rudolf
)
Die pathogenetische Rolle der Komplementspaltprodukte C3a und C5a bei der septischen Peritonitis
(Applicant
Köhl, Jörg
)
Die pathogenetische Rolle von C5a und Fc gamma-Rezeptoren in Typ III und Typ IV Überempfindlichkeitsreaktionen
(Applicant
Köhl, Jörg
)
Entstehung und Homeostase langlebiger Plasmazellen
(Applicant
Manz, Rudolf
)
Functional role of the miR-24-1 cluster in IL-6- and APRIL-dependent survival of plasma cells
(Applicant
Abram, Melanie
)
Identifizierung und Depletion von krankheitsrelevanten Lymphozyten- Subpopulationen zur Therapie des SLE
(Applicant
Manz, Rudolf
)
IL-10+ plasma cell mediated control of innate immunity
(Applicant
Manz, Rudolf
)
Regulation of B-1 lymphocyte trafficking through the C5a/C5aR1 axis
(Applicant
Karsten, Christian
)
The role of the anaphylatoxin C5a in intestinal immune responses
(Applicant
Köhl, Jörg
)
The role of the anaphylatoxins C3a and C5a in the pathogenesis of experimental allergic asthma
(Applicant
Köhl, Jörg
)
Untersuchung der Rolle der Chemokinrezeptoren CCR2 und CXCR3 bei B-Zell und Plasmazell-Homing und Differenzierung
(Applicant
Manz, Rudolf
)
Untersuchungen zur Extravasation und Migration dendritischer Zellen im schwangeren Uterus der Maus
(Applicant
Kruse, Andrea
)
Priority Programmes
Completed projects
Bone marrow plasma cells in autoimmune lupus modulating the function of bone metabolizing cells - osteoblasts and osteoclasts
(Applicant
Manz, Rudolf
)
Dissecting the osteoimmunological role of dickkopf-1 in arthritis and glucocorticoidinduced bone loss
(Applicants
Hofbauer, Lorenz C.
;
Rauner, Martina
)
Pasteurella multocida toxin as a tool to modulate bone and immune cell differentiation
(Applicant
Hieke-Kubatzky, Katharina
)
Clinical Research Units
Completed projects
Identifizierung von Signalen, die die Differenzierung und das Überleben von humanen Plasmazellen regulieren
(Applicant
Manz, Rudolf
)
KFO 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential
(Spokesperson
Zillikens, Detlef
)
The C5a/C5aR1 axis as a regulator of autoreactive IgG antibody glycosylation in pemphigoid diseases
(Applicant
Köhl, Jörg
)
The role of C5aR2 in the pathogenesis of pemphigoid diseases
(Applicants
Karsten, Christian
;
Schmidt, Enno
)
The Role of Lymphocyte-derived Factors in the Effector Phase of Pemphigoid Diseases
(Applicants
Bieber, Katja
;
Manz, Rudolf
)
CRC/Transfer Units
Completed projects
Analyse von biochemischen Parametern im Plasma von Sepsis-/SIRS-Risikopatienten
(Project Head
Köhl, Jörg
)
TFB 15: Die Bedeutung des Komplementspaltproduktes C3a als diagnostischer Frühmarker in der Sepsis
(Spokesperson
Köhl, Jörg
)
Verwaltung und zentrale Aufgaben
(Project Head
Köhl, Jörg
)
Major Research Instrumentation
Completed projects
High-End Zellsorter
Multi-Parameter Flow cytometer
Collaborative Research Centres
Current projects
C5a receptor 1 activation as a regulator of autoantibody production in pemphigoid disease
(Project Head
Köhl, Jörg
)
Crosstalk between T cells and B cells in the differentiation of pathogenic plasma cells in pemphigoid diseases
(Project Heads
Heine, Guido
;
Manz, Rudolf
)
The role of neutrophils in the regulation of the adaptive immunity in pemphigoid diseases
(Project Head
Karsten, Christian
)
Completed projects
Analyse humoraler und zellulärer Effektorsysteme bei der Xenotransplantation im diskordanten Kleintiermodell Meerschweinchen/Ratte
(Project Heads
Köhl, Jörg
;
Meyer zu Vilsendorf, Andreas
)
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads
Hiepe, Falk
;
Manz, Rudolf
)
Generation und Homeostase von autoreaktiven Plasmazellen bei Autoimmunerkrankungen
(Project Heads
Hiepe, Falk
;
Manz, Rudolf
)
Interactions between sleep and complement-driven regulation of intestinal dendritic cell functions
(Project Heads
Autenrieth, Ph.D., Stella E.
;
Köhl, Jörg
)
CRC/Transregios
Completed projects
The role of the anaphylatoxins C3a and C5a in the pathogenesis of experimental allergic asthma
(Project Head
Köhl, Jörg
)
Research Training Groups
Current projects
GRK 2633: Defining and Targeting Autoimmune Pre-Disease
(Spokesperson
Ludwig, Ralf Joachim
)
Completed projects
GRK 288: Structures and Mediators of the Interaction of Cells
(Spokesperson
Jelkmann, Wolfgang
)
GRK 1727: Modulation of Autoimmunity
(Spokesperson
Zillikens, Detlef
)
International Research Training Groups
Completed projects
GRK 1911: Immunregulation of Inflammation in Allergy and Infection
(Spokesperson
Köhl, Jörg
)
Clusters of Excellence
Completed projects
EXC 306: Inflammation at Interfaces
(Spokesperson
Schreiber, Stefan
)
Clusters of Excellence (ExStra)
Current projects
EXC 2167: Precision Medicine in Chronic Inflammation (PMI)
(Spokespersons
Niemann, Stefan
;
Riemekasten, Gabriela
;
Schreiber, Stefan
)
Additional Information
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