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Project Details

Institution

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Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Klinik für Pädiatrie mit SP Onkologie und Hämatologie

Address Augustenburger Platz 1
13353 Berlin
Deutschland

GERiT This institution in GERiT

13353 Berlin

Projects

Clinical Research Units
- Current projects
  - KFO 5023: BECAUSE-Y Berlin Center for Diagnosing, Understanding and Treating Antibody(Y)-mediated Neurological Diseases
    (Spokesperson Endres, Matthias )
  - Preclinical development of antibody-specific novel immunotherapies
    (Applicants Künkele-Langer, Annette ; Meisel, Andreas ; Reincke, Momsen )
- Completed projects
Research Fellowships
- Completed projects
Independent Junior Research Groups
- Completed projects
  - Recombinase-induced genomic structural variants in neuroblastoma (RecoN)
    (Applicant Henssen, Anton )
Research Grants
- Completed projects
Research Units
- Current projects
  - FOR 5628: Multiscale magnetic resonance elastography in cancer: The mechanical niche of tumor formation and metastatic spread – towards an improved diagnosis of cancer through mechanical imaging
    (Spokesperson Sack, Ingolf )
  - Neuroblastoma as pediatric tumor model: in vivo mechanical niches in zebrafish and patients
    (Applicants Eggert, Angelika ; Heeren-Hagemann, Anja )
CRC/Transregios
- Current projects
  - Engineering CAR-T cells against neuroblastoma with synthetic notch receptors to increase tumor-specificity and endogenous immune activation
    (Project Head Künkele-Langer, Annette )
Collaborative Research Centres
- Current projects
  - Central coordination of CRC1588
    (Project Head Eggert, Angelika )
  - Deciphering the principles of neuroblastoma metastasis to the bone marrow by integrated single-cell and spatial multi-omics
    (Project Heads Eggert, Angelika ; Haas, Ph.D., Simon )
  - Engineering CAR T cells to better find and eradicate neuroblastoma
    (Project Heads Höpken, Uta Elisabeth ; Künkele-Langer, Annette )
  - Extrachromosomal DNA (ecDNA) evolution and re-integration as a driver of progression and metastasis
    (Project Heads Henssen, Anton ; Schwarz, Roland )
  - Molecular technology infrastructure and support
    (Project Heads Altmüller, Janine ; Lodrini, Marco ; Ralser, Markus )
  - Neuroblastoma cell states and their link to the microenvironment, disease progression and therapy response
    (Project Heads Henssen, Anton ; Junker, Jan Philipp )
  - Plasma proteome and metabolome signatures to better understand, monitor and predict neuroblastoma evolution
    (Project Heads Deubzer, Ph.D., Hedwig E. ; Ralser, Markus )
  - Preventing neuroblastoma relapses by molecular characterization and targeted elimination of minimal residual disease cells
    (Project Heads Künkele-Langer, Annette ; Versteeg, Rogier )
  - SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
    (Spokesperson Eggert, Angelika )
  - Spatial organization and function of RNA in primary neuroblastomas and their TME
    (Project Heads Eggert, Angelika ; Rajewsky, Nikolaus )
  - Support with preclinical animal models
    (Project Heads Dörr, Jan ; Heeren-Hagemann, Anja ; Schulte, Johannes Hubertus )
  - Targeting MYCN-dependent resolution of transcription-replication conflicts
    (Project Heads Büchel, Gabriele ; Henssen, Anton )
  - Targeting MYCN multiprotein complexes in neuroblastoma with miniproteins
    (Project Heads Dörr, Jan ; Wanker, Erich E. )
  - The Neuroblastoma Evolution integrated research training group
    (Project Heads Blüthgen, Nils ; Künkele-Langer, Annette )
  - The post-translationally modified neuroblastoma proteome as a source for druggable vulnerabilities
    (Project Heads Dörr, Jan ; Mertins, Philipp )
  - The role of neuroblastoma-secreted exosomes in pre-metastatic niche formation
    (Project Heads Deubzer, Ph.D., Hedwig E. ; Gerhardt, Holger )
- Completed projects
  - Development of tailored protocols for tolerance induction by immunoablation and hematopoietic stem cell transplantation in autoimmune diseases
    (Project Heads Alexander, Tobias ; Arnold, Renate ; Hiepe, Falk )
Research Training Groups
- Current projects
  - GRK 2424: Computational Methods for Oncology: Towards Personalized Therapies in Cancer
    (Spokesperson Blüthgen, Nils )
NFDI technical and methodological consortia
- Current projects
  - National Research Data Infrastructure for Immunology
    (Spokesperson Busse, Christian )

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