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Institution
Julius-Maximilians-Universität Würzburg
Biozentrum der Universität Würzburg
Lehrstuhl für Bioinformatik
Address
Am Hubland
97074 Würzburg
Deutschland
GERiT
This institution in GERiT
97074 Würzburg
Projects
Research Grants
Current projects
A joint experimental and computational approach to study the functions of the RNA-binding protein PURA and its role in the neurodevelopmental disease PURA Syndrome
(Applicants
Niessing, Dierk
;
Zarnack, Katharina
)
Alternative splicing of CD19 mRNA in pediatric leukemia and CART-19 therapy resistance - Regulators, genetic variants and cryptic isoforms
(Applicants
König, Ph.D., Julian
;
Legewie, Stefan
;
Zarnack, Katharina
)
Analysis of neuronal remodeling during transitions between reproductive live cycle and dauer stage in C. elegans
(Applicants
Dandekar, Thomas
;
Kollmannsberger, Philip
;
Stigloher, Christian
)
Completed projects
Evolution of molecular mechanisms that control stomatal closure
(Applicants
Hedrich, Rainer
;
Roelfsema, Ph.D., Rob
;
Schultz, Jörg
)
Genetic and immunologic basis of pathogenic and mutualistic interactions between bacteria and their ant hosts
(Applicant
Gross, Roy
)
GEPAT2 (Genome Expression Pathway Analysis Tool 2) - Von der Genexpression zum Medikament
(Applicant
Schultz, Jörg
)
Modeling of the TNF - TNF receptor signaling network
(Applicants
Dandekar, Thomas
;
Wajant, Harald Günther
)
Vergleichende Phylogenie zwischen Arten bis hin zum "tree of Life" basierend auf einer ITS- (internal transcribed spacer) Sequenz-Strukturdatenbank und neuen Algorithmen
(Applicant
Müller, Tobias
)
Priority Programmes
Completed projects
Host adapted metabolism in bacterial infections: Data integration and refined metabolic modelling
(Applicant
Dandekar, Thomas
)
Mechanistic and functional characterization of Makorin 1 mRNPs
(Applicants
König, Ph.D., Julian
;
Roignant, Jean-Yves
;
Zarnack, Katharina
)
Metabolism of intracellular Salmonella enterica: One liefstyle in intracellular infections
(Applicants
Dandekar, Thomas
;
Hensel, Michael
)
Modeling metabolism in intracellular infections comparing Salmonella and Listeria
(Applicant
Dandekar, Thomas
)
mRNP assembly at the 3' splice site studied by functional genomics and structural biology
(Applicants
König, Ph.D., Julian
;
Sattler, Michael
)
Stoffwechselwegvorhersagen mittels Genomanalyse und Enzymkettenmodellierung
(Applicant
Bork, Peer
)
The analysis of membrane signalling networks in latex bead- and mycobacterial-phagosomes regulating actin binding and de novo assembly
(Applicant
Dandekar, Thomas
)
The evolution of actin nucleation - understanding the history of the players
(Applicant
Schultz, Jörg
)
Research Units
Completed projects
Combination of transcriptome-wide and structural approaches to study SHE binding to RNA localization elements in budding yeast
(Applicants
König, Ph.D., Julian
;
Niessing, Dierk
;
Zarnack, Katharina
)
Deciphering the molecular code of protein-RNA binding during mRNA localisation
(Applicant
Zarnack, Katharina
)
FOR 2333: Macromolecular Complexes in mRNA translocation
(Spokesperson
Niessing, Dierk
)
Collaborative Research Centres
Current projects
Data management platform to facilitate data integration and in silico identification of decision points in infection
(Project Head
Dandekar, Thomas
)
Sources and consequences of intrinsic genomic instability across human cell types
(Project Heads
Roukos, Vassilis
;
Zarnack, Katharina
)
Completed projects
Comparative modeling of signaling in platelets
(Project Head
Dandekar, Thomas
)
Dissecting the regulatory mechanisms of alternative polyadenylation and nuclear retention of mRNAs by SR proteins
(Project Heads
Müller-McNicoll, Michaela
;
Zarnack, Katharina
)
Metabolic and bioinformatical analysis of drug effects on cellular networks
(Project Heads
Dandekar, Thomas
;
Unger, Matthias
)
Thiol-dependent redox networks as targets of antimalarial agents
(Project Heads
Dandekar, Thomas
;
Schirmer, Heiner
)
WBP Return Grant
Completed projects
Rückkehrstipendium
(Applicant
Neuberger, Arthur
)
CRC/Transregios
Current projects
Data integration platform and systems medicine efforts to foster GvL and GvHD research
(Project Heads
Dandekar, Thomas
;
Holler, Ernst
;
Kehr, Birte
;
Kunz, Meik
)
Evolution of fungal virulence and host responses comparing Candida, Lichtheimia and Aspergillus spp.
(Project Heads
Dandekar, Thomas
;
Schuster, Stefan
)
Host-pathogen interactions triggering infection signal networks in Aspergillus fumigatus, Candida albicans and human immune cells
(Project Heads
Dandekar, Thomas
;
Dittrich, Marcus
;
Kaleta, Christoph
)
The role of arcRNAs and nuclear condensate dynamics in the splicing response to hypoxia
(Project Heads
Müller-McNicoll, Michaela
;
Zarnack, Katharina
)
Completed projects
An integrated view on adaptation of Staphylococcus aureus
(Project Heads
Bernhardt, Jörg
;
Dandekar, Thomas
;
Mäder, Ulrike
)
A systems biology perspective of regulatory and metabolic adaptation of Staphylococcus aureus to infection-related conditions
(Project Heads
Dandekar, Thomas
;
Fuchs, Stephan
;
Pané-Farré, Jan
;
Völker, Uwe
)
Bioinformatical analysis and metabolic modelling of growth phase-related changes in staphylococci
(Project Head
Dandekar, Thomas
)
Elucidating protein-RNA interactions in circRNA biogenesis and function
(Project Heads
Dimmeler, Stefanie
;
Zarnack, Katharina
)
Platelet Proteomics Platform (PPP): combining proteomics, phosphoproteomics, lipidomics and bioinformatics
(Project Heads
Ahrends, Ph.D., Robert
;
Dandekar, Thomas
;
Lämmerhofer, Michael
;
Sickmann, Albert
)
The Virtual Platelet Platform ViPP: An Images and Systems Biology data repository and workbench
(Project Heads
Dandekar, Thomas
;
Heinze, Katrin G.
)
Research Training Groups
Current projects
GRK 2157: 3D Tissue Models for Studying Microbial Infections by Human Pathogens
(Spokesperson
Rudel, Thomas
)
Completed projects
GRK 300: Pathogenic Microorganisms: Molecular Mechanisms and Genomic Approaches
(Spokesperson
Clayton, Christine Elizabeth
)
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