Host-pathogen interactions triggering infection signal networks in Aspergillus fumigatus, Candida albicans and human immune cells (B02)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 210879364

Project B2 aims at an in-depth analysis of host-pathogen signaling networks by linking the established surface interactome and signal transduction with downstream (transcriptional) responses in fungi and immune cells. We will resolve host-pathogen signaling interactions on a molecular level in a cell type-specific manner in order to tackle the question: How do macrophages, neutrophils and T-cells interact with pathogenic fungi under specific conditions? B2 will also describe in detail the signal transduction of immune cells and fungal cells under various infection conditions, such as infection onset and local infection versus sepsis.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 124: Pathogenic Fungi and their Human Host: Networks of Interaction - FungiNet
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Heads: Professor Dr. Thomas Dandekar; Dr. Marcus Dittrich; Professor Dr. Christoph Kaleta, until 6/2017