Project Details
Projekt
Chaperone Mechanics of the Hsp90 System (A04)
Subject Area
Biophysics
Term
from 2010 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 111166240
Heat shock protein 90 (Hsp90) is a dimeric molecular chaperone essential for the maturation and folding of a large set of different client proteins. In this project, we will use single molecule experiments to study the mechanics and dynamics that Hsp90 undergoes, especially in the presence of nucleotides, co-chaperones and clients. Together with biochemical and in vivo experiments this will provide detailed insights into the conformational regulation of the Hsp90 machinery and how it chaperones its clients.
DFG Programme
Collaborative Research Centres
Subproject of
SFB 863:
Forces in Biomolecular Systems
Applicant Institution
Technische Universität München (TUM)
Project Heads
Professor Dr. Johannes Buchner; Professor Dr. Thorsten Hugel, until 8/2014; Professor Dr. Matthias Rief
