Mechanism of IGF1-dependent modulation of myeloid cell function and metabolism in acute myocardial infarction (A06)

• Subject Area: Cardiology, Angiology
• Term: from 2015 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 236177352

It was shown previously that short-term IGF1 treatment after acute myocardial infarction reduces scar size, enhances angiogenesis, and improves cardiac function via modulation of myeloid cells. In the next period the project aims at i) identification of the cell type being responsible for this effect (macrophages, neutrophils), ii) elucidation of the molecular alterations induced by IGF1 in these cells, and iii) investigation of the IGF1-mediated cardioprotection in the context of insulin resistance/ T2DM as a relevant comorbidity in AMI. In summary, the project will identify novel mechanisms of immune cell modulation which improve the outcome after AMI.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1116: Master switches in cardiac ischemia
• Applicant Institution: Heinrich-Heine-Universität Düsseldorf
• Project Head: Professor Dr. Axel Gödecke