High-resolution multi-parametric cell and tissue analysis (Z02)

• Subject Area: Medicine
• Term: since 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 272983813

In depth characterization of immune responses in vivo requires specific methodologies that are optimized for low cell numbers, sparse tissue samples and noisy data. To tackle these challenges, the aims of project Z02 are (i) the establishment of highly sensitive immunoassays and histopathological analyses (ii) sorting of rare cell populations and (iii) integration of cutting-edge mass cytometry. Bioinformatics analysis (former part of Z02) will be combined with single cell transcriptomic and (epi)genomic analyses as new project Z03N.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Dr. Immanuel Anton Andrä; Dr. Tanja Bauer, until 6/2020; Professor Dr. Bertram Bengsch, Ph.D., since 7/2020; Professor Dr. Roland Eils, until 6/2020; Professorin Dr. Carolin Mogler, since 7/2020; Professor Dr. Christoph Neumann-Haefelin, until 6/2020; Dr. Matthias Schiemann