SFB 1286:  Quantitative Synaptology

• Subject Area: Medicine ; Biology ; Physics
• Term: since 2017
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

No abstract available

• DFG Programme: Collaborative Research Centres

Current projects

• A02 - Structure of synaptic organelles by X-ray diffraction and imaging (Project Head Salditt, Tim )
• A03 - Molecular-scale analysis of key points in synaptic activity (Project Heads Rizzoli, Ph.D., Silvio-Olivier ;  Simeth-Crespi, Nadja Anita )
• A04 - Investigating the ultrastructural effects of activity and aging on vesicle recycling and protein turnover (Project Head Wichmann, Carolin )
• A05 - Mitochondrial heterogeneity in synapses (Project Head Jakobs, Stefan )
• A06 - Proteostasis processes at synaptic mitochondria (Project Head Rehling, Peter )
• A07 - Surface mobility of glutamate receptors (Project Heads D' Este, Elisa ;  Hell, Stefan W. )
• A09 - Syntax of post-translational protein modifications by UBLs in presynaptic function (Project Heads Brose, Nils ;  Tirard, Marilyn )
• A11 - Regulation of synaptic functional heterogeneity and diversity (Project Head Lipstein-Thoms, Ph.D., Noa )
• A12 - Nanometric architecture of the synaptic cytoskeleton (Project Head Fernandez Busnadiego, Ruben )
• B02 - The synaptic vesicle cluster as a regulator of presynaptic biomechanics (Project Heads Köster, Sarah ;  Reshetniak, Sofiia )
• B04 - In vitro reconstitution of inhibitory GABAergic postsynapses (Project Head Steinem, Claudia )
• B05 - Quantitative molecular physiology of calyceal synapses (Project Head Moser, Tobias )
• B06 - The role of RNA in synapse physiology and neurodegeneration (Project Heads Fischer, André ;  Outeiro, Tiago Fleming )
• B08 - Protein aggregation: markers and drivers of synaptic dysfunction (Project Head Outeiro, Tiago Fleming )
• B10 - Nanoscale Dynamics and Regulation of Synapsin Condensates (Project Head Milovanovic, Dragomir )
• B11 - Gating and expression of long-term synaptic plasticity as an interplay between parallel transmission sites and astrocyte signaling (Project Head Schlüter, Oliver M. )
• B12 - Super-resolution analysis of neuron-glia interplay at tripartite synapses (Project Head Nägerl, Ph.D., Urs Valentin )
• C01 - The influence of molecular heterogeneities on liquid phases in the synapse (Project Head Tetzlaff, Christian )
• C02 - Nanoscale geometric focusing of synaptic calcium domains (Project Head Wolf, Fred )
• C03 - Long-term dynamics of the post-synapse in relation to its surroundings (Project Head Fauth, Michael )
• C06 - Coarse-grained simulation of the role of local environment on presynaptic release: from fusion to fission (Project Head Müller, Marcus )
• C08 - Experimental and theoretical analysis of single active zone function (Project Head Moser, Tobias )
• C09 - Linking multi-timescale dynamics in the presynapse to neural computation (Project Head Priesemann, Viola )
• C10 - Innovative deep learning approaches enable quantitative analyses of synaptic imaging datasets (Project Head Pape, Constantin )
• C11 - Energy optimization as an organizing principle for protein dynamics at the synapse (Project Head Tchumatchenko, Tatjana )
• C12 - A multiscale analysis of synaptic turnover for modeling the dynamic changes that shape synaptic function (Project Heads Fornasiero, Ph.D., Eugenio ;  Senk, Johanna )
• Z01 - Central Tasks (Project Head Rizzoli, Ph.D., Silvio-Olivier )
• Z02 - Integration of computational models and experimental data (Project Heads Bonn, Stefan ;  Tetzlaff, Christian )
• Z04 - Quantitative visualization and analysis of synaptic proteins using nanobodies (Project Head Opazo, Felipe )

Completed projects

• A01 - The ultrastructure of synapses in action (Project Head Cooper, Ph.D., Benjamin )
• A08 - The role of post-translationally modified proteins in synaptic transmission (Project Heads Jahn, Reinhard ;  Urlaub, Henning )
• A10 - Protein–protein interactions at the synapse monitored by quantitative protein cross-linking (Project Head Urlaub, Henning )
• B01 - The organization of structural lipids in synaptic membranes (Project Head Phan, Thi Ngoc Nhu )
• B03 - Mapping the protein and lipid organization in the plasma membrane of neurons using rapid rupture event imaging (Project Head Janshoff, Andreas )
• B09 - Cytoskeletal alterations contributing to synapto-axonal dysfunction in Parkinson’s disease (Project Head Lingor, Paul )
• C05 - The synapse as a complex physical environment (Project Head Klumpp, Stefan )
• Z03 - Simple multi-color super-resolution imaging by 10x expansion microscopy (Project Head Rizzoli, Ph.D., Silvio-Olivier )

• Applicant Institution: Georg-August-Universität Göttingen
• Participating University: Universitätsklinikum Bonn; Institut für Experimentelle Epileptologie und Kognitionsforschung; Universitätsklinikum Hamburg-Eppendorf
• Participating Institution: Forschungszentrum Jülich GmbH ; Institute for Advanced Simulation (IAS); Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP); im Forschungsverbund Berlin e.V.; Max-Planck-Institut für Dynamik und Selbstorganisation (MPIDS); Max-Planck-Institut für Multidisziplinäre Naturwissenschaften; Max-Planck-Institut für medizinische Forschung; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE); c/o Charité - Universitätsmedizin Berlin; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE); Standort Göttingen
• Spokesperson: Professor Silvio-Olivier Rizzoli, Ph.D.