Signaling mechanisms of synaptic state transitions in relation to long-term synaptic plasticity (B11#)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 317475864

Bidirectional long-term synaptic plasticity induces synaptic state transitions that establish specific synaptic properties. Based on specific phosphorylation site changes on AMPA-type glutamate receptor subunits, we identified two such state transitions. We aim to decipher the signalling pathways that lead to the phosphorylation and dephosphorylation of AMPA-type glutamate receptor complexes to express state-dependent forms of long-term synaptic plasticity. We expect that results will reveal details up to the precision of single amino acids and the identity of specific signalling complexes governing AMPA-type glutamate receptor synapse incorporation or removal.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1286: Quantitative Synaptology
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Oliver M. Schlüter