Understanding the mechanisms leading to autoimmune adrenalitis by generating the first experimental animal model (A03)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine
• Term: from 2017 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 314061271

(I) Characterise in detail the experimental autoimmune adrenalitis (EAA) model by assessing effects of autoimmunity on adrenal function and steroidogenesis as well as investigate the inflammatory cell infiltrate to the adrenal glands.(II) Understand the underlying auto-immune mechanisms of EAA in order to optimize further model development. In particular, we will determine whether Th1- versus Th17-mediated cell responses dominate in EAA generation.(III) Study the role of immunomodulatory interventions in the context of EAA.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 205: The Adrenal: Central Relay in Health and Disease
• Applicant Institution: Technische Universität Dresden
• Project Head: Professor Dr. Triantafyllos Chavakis