Characterization of the Extracellular Matrix of the Aortic Wall during the Development of Aneurysms Using Molecular and Biophysical MRI (B01)

• Subject Area: Radiology
• Term: since 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 372486779

Pathological changes in the extracellular matrix (ECM) play a significant role in the development of abdominal aortic aneurysms (AAAs). In the 2nd funding period, B01 will shift the focus from the now completed successful identification of reliable dual-probe molecular approaches targeting the ECM to imaging-based monitoring of molecular therapy response in AAA. Besides, the established molecular and biophysical MRI techniques will be translated to a porcine human-relevant AAA model. The best imaging approach for AAA risk assessment and noninvasive monitoring of response to treatment will be identified.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1340: In vivo Visualization of Extracellular Matrix Pathology „Matrix in Vision“
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Privatdozentin Dr. Lisa Adams, since 7/2022; Dr. Julia Brangsch, since 7/2022; Professor Dr. Bernd Hamm; Professor Dr. Marcus R. Makowski, until 6/2022