Renoprotection in crescentic glomerulonephritis by ANCA (C01)

• Subject Area: Nephrology ; Rheumatology
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

We will test the hypothesis that regulated cell death pathways, namely necroptosis and ferroptosis, mediate kidney injury in autoimmune ANCA-associated vasculitides (AV) and that inhibiting key elements of these pathways provides renoprotection. Specifically, we will characterize (I) mechanisms involved in the regulation of the generation of neutrophil extracellular traps (NETs) and monocyte extracellular traps (METs) in AV, (II) necroptotic and ferroptotic cell deaths in the different kidney compartments, and (III) therapeutic targets of regulated cell death pathways that cause AV-induced kidney damage. Our studies will elucidate AV disease mechanisms and identify renoprotective treatment strategies that will then be tested in clinical trials.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professor Dr. Ralph Kettritz; Privatdozent Dr. Adrian Schreiber